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公开(公告)号：US20210292337A1
公开(公告)日：2021-09-23
申请号：US17161324
申请日：2021-01-28
发明人： Stephanos Ioannidis , Adam Charles Talbot , Bruce Follows , Alexandre Joseph Buckmelter , Minghua Wang , Ann-Marie Campbell , David R. Lancia, JR.
IPC分类号： C07D495/04 , A61K31/519
摘要： The disclosure relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula: where R1, R2, R3, R5, R5′, X1, X2, n, and m are described herein.
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公开(公告)号：US11739071B2
公开(公告)日：2023-08-29
申请号：US17096349
申请日：2020-11-12
发明人： Stephanos Ioannidis , Adam Charles Talbot , Bruce Follows , Alexandre Joseph Buckmelter , Minghua Wang , Ann-Marie Campbell , David R. Lancia, Jr.
IPC分类号： C07D401/06 , C07D239/88 , C07D487/04 , C07D471/04
CPC分类号： C07D401/06 , C07D239/88 , C07D471/04 , C07D487/04
摘要： The present disclosure relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula:
where R1, R2, R3, R4, R4′, X1, Y1, Y2, Y3, Y4, n, and m are described herein.-
公开(公告)号：US20210332052A1
公开(公告)日：2021-10-28
申请号：US17186915
申请日：2021-02-26
发明人： Stephanos Ioannidis , Adam Charles Talbot , Bruce Follows , Alexandre Joseph Buckmelter , Minghua Wang , Ann-Marie Campbell , Darby Rye Schmidt , David Joseph Guerin , Justin Andrew Caravella , R. Bruce Diebold , Anna Ericsson , David R. Lancia, JR.
IPC分类号： C07D487/04 , C07D519/00 , A61K31/519
摘要： The invention relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula: where m, n, X1, X2, R1-R5, R5′ and R6 are described herein.
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公开(公告)号：US20210130321A1
公开(公告)日：2021-05-06
申请号：US17096349
申请日：2020-11-12
发明人： Stephanos Ioannidis , Adam Charles Talbot , Bruce Follows , Alexandre Joseph Buckmelter , Minghua Wang , Ann-Marie Campbell , David R. Lancia, JR.
IPC分类号： C07D401/06 , C07D239/88 , C07D487/04 , C07D471/04
摘要： The present disclosure relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula: where R1, R2, R3, R4, R4′, X1, Y1, Y2, Y3, Y4, n, and m are described herein.
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公开(公告)号：US20210323978A1
公开(公告)日：2021-10-21
申请号：US17179046
申请日：2021-02-18
发明人： Stephanos Ioannidis , Adam Charles Talbot , Bruce Follows , Alexandre Joseph Bckmelter , Minghua Wang , Ann-Marie Campbell
IPC分类号： C07D513/04 , C07D487/04
摘要： The disclosure relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula: where R1, R2, R3, R4, R5, R5′, X1, X2, X3, n, and m are described herein.
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公开(公告)号：US10927130B2
公开(公告)日：2021-02-23
申请号：US16515281
申请日：2019-07-18
发明人： Stephanos Ioannidis , Adam Charles Talbot , Bruce Follows , Alexandre Joseph Buckmelter , Minghua Wang , Ann-Marie Campbell
IPC分类号： C07D487/04 , C07D513/04
摘要： The disclosure relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula: where R1, R2, R3, R4, R5, R5′, X1, X2, X3, n, and m are described herein.
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公开(公告)号：US10981915B2
公开(公告)日：2021-04-20
申请号：US16449599
申请日：2019-06-24
发明人： Stephanos Ioannidis , Adam Charles Talbot , Bruce Follows , Alexandre Joseph Buckmelter , Minghua Wang , Ann-Marie Campbell
IPC分类号： C07D487/04
摘要： The invention relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula: where R1, R2, R3, R4, R5, R5′, R6, X1, X2, m, and n are described herein.
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公开(公告)号：US10934299B2
公开(公告)日：2021-03-02
申请号：US16517149
申请日：2019-07-19
发明人： Stephanos Ioannidis , Adam Charles Talbot , Bruce Follows , Alexandre Joseph Buckmelter , Minghua Wang , Ann-Marie Campbell , Darby Rye Schmidt , David Joseph Guerin , Justin Andrew Caravella , R. Bruce Diebold , Anna Ericsson , David R. Lancia, Jr.
IPC分类号： C07D487/04 , C07D519/00 , A61K31/519
摘要： The invention relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula: where m, n, X1, X2, R1-R5, R5′ and R6 are described herein.
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公开(公告)号：US10906916B2
公开(公告)日：2021-02-02
申请号：US16515194
申请日：2019-07-18
发明人： Stephanos Ioannidis , Adam Charles Talbot , Bruce Follows , Alexandre Joseph Buckmelter , Minghua Wang , Ann-Marie Campbell , David R. Lancia, Jr.
IPC分类号： C07D495/04 , A61K31/519
摘要： The disclosure relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula: where R1, R2, R3, R5, R5′, X1, X2, n, and m are described herein.
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