公开(公告)号：US10526323B2

公开(公告)日：2020-01-07

申请号：US15547781

申请日：2016-02-01

Applicant: Vanderbilt University

Inventor： P. Jeffrey Conn ,  Corey R. Hopkins ,  Craig W. Lindsley ,  Colleen M. Niswender ,  Darren W. Engers ,  Joe Panarese ,  Joanne Bronson ,  Yong-Jin Wu ,  Jason Guernon

IPC: C07D403/12 ,  C07D471/04 ,  C07D487/04 ,  A61K31/4162 ,  A61K45/06 ,  A61K31/416 ,  A61K31/437 ,  A61K31/4985 ,  A61K31/5377 ,  C07D231/56 ,  C07D519/00 ,  C07D413/14

Abstract: Compounds, including those of the following formula: wherein the variables are defined herein, which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction.

公开(公告)号：US20180022746A1

公开(公告)日：2018-01-25

申请号：US15547781

申请日：2016-02-01

Applicant: Vanderbilt University

Inventor： P. Jeffrey Conn ,  Corey R. Hopkins ,  Craig W. Lindsley ,  Colleen M. Niswender ,  Darren W. Engers ,  Joe Panarese ,  Joanne Bronson ,  Yong-Jin Wu ,  Jason Guernon

IPC: C07D471/04 ,  C07D519/00 ,  C07D413/14 ,  C07D487/04 ,  C07D403/12

Abstract: Compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction.