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1.发明申请Sterile Polymerizable Systems And Kits And Methods Of Their Manufacture And Use 审中-公开无菌可聚合系统及其制造和使用方法公开(公告)号：US20100226820A1
公开(公告)日：2010-09-09
申请号：US12782036
申请日：2010-05-18
CPC分类号： A61L2/081 , A61L2/0017 , A61L2/0023 , A61L2/022 , A61L2/04 , A61L2/206 , A61L2202/24
摘要： The present invention overcomes the difficulties in the sterilization and delivery of viscous, multi-component compositions that require pre-mixing prior to usage by disclosing a sterile, multi-component, ready-to-use product wherein each component is sterilized independently and then assembled into a sterilized delivery kit. In certain preferred embodiments of the present invention, a sterile, polymerizable system is provided that comprises a plurality of sterile polymerizable monomers, said monomers having been sterilized by passing them through a filter; at least one sterile filler which has been exposed to conditions effective to render said filler sterile, and the sterile monomers and the sterile filler being blended together to form at least one substantially homogeneous blend contained within a sterile delivery vessel. Still other embodiments include a single-use kit that comprises a delivery gun, mix tips, and cartridges that comprise one or more pastes of the present invention that are housed within one or more pouches to ensure sterility of the internal contents.
摘要翻译： 本发明克服了在使用前需要预混合的粘性多组分组合物的灭菌和输送的困难，所述组合物通过公开无菌的多组分即用型产品，其中各组分被独立灭菌然后组装 成为灭菌的递送试剂盒。 在本发明的某些优选实施方案中，提供了包含多个无菌可聚合单体的无菌可聚合体系，所述单体通过使其通过过滤器被灭菌; 已经暴露于有效使所述填料无菌的条件的至少一种无菌填料，并且将无菌单体和无菌填料混合在一起以形成包含在无菌递送容器内的至少一种基本均匀的混合物。 还有其它实施方案包括一次性使用的试剂盒，其包括输送枪，混合物末端和包含本发明的一种或多种糊剂的药筒，所述药膏包含在一个或多个袋中以确保内部内容物的无菌性。
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2.发明申请Sterile Polymerizable Systems And Kits And Methods Of Their Manufacture And Use 审中-公开无菌可聚合系统及其制造和使用方法公开(公告)号：US20080319380A1
公开(公告)日：2008-12-25
申请号：US12205510
申请日：2008-09-05
CPC分类号： A61L2/081 , A61L2/0017 , A61L2/0023 , A61L2/022 , A61L2/04 , A61L2/206 , A61L2202/24
摘要： The present invention overcomes the difficulties in the sterilization and delivery of viscous, multi-component compositions that require pre-mixing prior to usage by disclosing a sterile, multi-component, ready-to-use product wherein each component is sterilized independently and then assembled into a sterilized delivery kit. In certain preferred embodiments of the present invention, a sterile, polymerizable system is provided that comprises a plurality of sterile polymerizable monomers, said monomers having been sterilized by passing them through a filter; at least one sterile filler which has been exposed to conditions effective to render said filler sterile, and the sterile monomers and the sterile filler being blended together to form at least one substantially homogeneous blend contained within a sterile delivery vessel. Still other embodiments include a single-use kit that comprises a delivery gun, mix tips, and cartridges that comprise one or more pastes of the present invention that are housed within one or more pouches to ensure sterility of the internal contents.
摘要翻译： 本发明克服了在使用前需要预混合的粘性多组分组合物的灭菌和输送的困难，所述组合物通过公开无菌的多组分即用型产品，其中各组分被独立灭菌然后组装 成为灭菌的递送试剂盒。 在本发明的某些优选实施方案中，提供了包含多个无菌可聚合单体的无菌可聚合体系，所述单体通过使其通过过滤器被灭菌; 已经暴露于有效使所述填料无菌的条件的至少一种无菌填料，并且将无菌单体和无菌填料混合在一起以形成包含在无菌递送容器内的至少一种基本均匀的混合物。 还有其它实施方案包括一次性使用的试剂盒，其包括输送枪，混合物末端和包含本发明的一种或多种糊剂的药筒，所述药膏包含在一个或多个袋中以确保内部内容物的无菌性。
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