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公开(公告)号：US20210077283A1
公开(公告)日：2021-03-18
申请号：US17005746
申请日：2020-08-28
发明人： Chung Hao Yeh , Jennifer Gong , Brent Seybold , Christopher Ken , Suji Shetty , Edward F. Ruppel, JR. , Robert Stern
摘要： An implantable frame comprises a plurality of corner structures configured to decrease pressure to the vessel wall and define pulsatility enhancing windows of the implantable frame. The corner structures may comprise plurality of neighboring longitudinal struts that extend in a longitudinal direction of the blood vessel when placed to form the vessel wall to a substantially polygonal cross-section and distribute pressure loading of the corner structure among the plurality of neighboring longitudinal struts to improve biocompatibility. The corner structures also allow increased forming of the vessel wall and can provide stretching of the vessel wall to enhance pulsatility of the vessel wall.
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公开(公告)号：US20160038317A1
公开(公告)日：2016-02-11
申请号：US14921171
申请日：2015-10-23
发明人： Chung Hao Yeh , Jennifer Gong , Brent Seybold , Christopher Ken , Suji Shetty , Ted Ruppel , Robert Stern
摘要： An implantable frame comprises a plurality of corner structures configured to decrease pressure to the vessel wall and define pulsatility enhancing windows of the implantable frame. The corner structures may comprise plurality of neighboring longitudinal struts that extend in a longitudinal direction of the blood vessel when placed to form the vessel wall to a substantially polygonal cross-section and distribute pressure loading of the corner structure among the plurality of neighboring longitudinal struts to improve biocompatibility. The corner structures also allow increased forming of the vessel wall and can provide stretching of the vessel wall to enhance pulsatility of the vessel wall.
摘要翻译： 可植入框架包括多个角结构，其被构造成减小对血管壁的压力并且限定可植入框架的脉动增强窗口。 拐角结构可以包括多个相邻的纵向支柱，其在放置时在血管壁的纵向方向上延伸以形成基本上多边形的横截面，并且将多个相邻的纵向支柱中的角结构的压力负载分配到 提高生物相容性。 角结构还允许增加血管壁的形成，并且可以提供血管壁的拉伸以增强血管壁的脉动。
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公开(公告)号：US10653513B2
公开(公告)日：2020-05-19
申请号：US15901790
申请日：2018-02-21
发明人： Brent Seybold , Christopher Ken , Jennifer Gong , Suji Shetty , Robert Stern , Edmund Roschak
IPC分类号： A61F2/06 , A61B5/00 , A61B34/10 , A61F2/856 , A61F2/90 , A61F2/95 , A61F2/89 , A61F2/915 , A61B5/0205 , A61B90/00
摘要： Systems and methods for screening a subject for a therapy are described. A mechanical stimulation device positioned near at target location of a blood vessel to provide a mechanical stimulus to the blood vessel. The mechanical stimulus increases strain in one or more regions of the blood vessel, such as by modifying the cross-sectional geometry and/or area of the blood vessel to have different regions of different curvature A baroreflex or related physiological response in response to the mechanical stimulation is detected. In response to the detected response, it is determined whether the subject is appropriate for the therapy and/or which of a plurality of implants with different geometries and/or cross-sectional areas is most optimally suited for deployment in the subject.
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公开(公告)号：US10786372B2
公开(公告)日：2020-09-29
申请号：US14921171
申请日：2015-10-23
发明人： Chung Hao Yeh , Jennifer Gong , Brent Seybold , Christopher Ken , Suji Shetty , Edward F. Ruppel, Jr. , Robert Stern
摘要： An implantable frame comprises a plurality of corner structures configured to decrease pressure to the vessel wall and define pulsatility enhancing windows of the implantable frame. The corner structures may comprise plurality of neighboring longitudinal struts that extend in a longitudinal direction of the blood vessel when placed to form the vessel wall to a substantially polygonal cross-section and distribute pressure loading of the corner structure among the plurality of neighboring longitudinal struts to improve biocompatibility. The corner structures also allow increased forming of the vessel wall and can provide stretching of the vessel wall to enhance pulsatility of the vessel wall.
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