公开(公告)号：US20090131430A1

公开(公告)日：2009-05-21

申请号：US11720047

申请日：2005-11-23

申请人： Venkata P. Palle ,  Rakesh Kumar Singh ,  Sanjay Malhotra ,  Yogesh Bhaskarrao Waman ,  Ashwani Verma ,  Abhijit Ray ,  Geeta Sharma

发明人： Venkata P. Palle ,  Rakesh Kumar Singh ,  Sanjay Malhotra ,  Yogesh Bhaskarrao Waman ,  Ashwani Verma ,  Abhijit Ray ,  Geeta Sharma

IPC分类号： A61K31/5377 ,  C07D471/04 ,  A61P29/00 ,  A61K31/519

CPC分类号： C07D471/04

摘要： The present invention relates to novel azabicyclo derivatives as anti-inflammatory agents. The compounds provided herein can be useful for inhibition and prevention of inflammation and associated pathologies including inflammatory and autoimmune diseases such as sepsis, rheumatoid arthritis, inflammatory bowel disease, type-1 diabetes, asthma, chronic obstructive pulmonary disorder, organ transplant rejection and psoriasis. Also provided herein are pharmacological compositions containing compounds provided herein and associated methods of treating sepsis, rheumatoid arthritis, inflammatory bowel disease, type-1 diabetes, asthma, chronic obstructive pulmonary disorder, organ transplant rejection and psoriasis, and other inflammatory and/or autoimmune disorders, using the compounds.

摘要翻译： 本发明涉及新型的氮杂二环衍生物作为抗炎剂。 本文提供的化合物可用于抑制和预防炎症和相关病理，包括炎性和自身免疫性疾病，例如败血症，类风湿性关节炎，炎性肠病，1型糖尿病，哮喘，慢性阻塞性肺病，器官移植排斥反应和牛皮癣。 本文还提供含有本文提供的化合物的药物组合物和治疗败血症，类风湿性关节炎，炎性肠病，1型糖尿病，哮喘，慢性阻塞性肺病，器官移植排斥反应和牛皮癣以及其它炎性和/或自身免疫性疾病的相关方法 ，使用该化合物。

公开(公告)号：US20090036472A1

公开(公告)日：2009-02-05

申请号：US11815251

申请日：2006-02-01

申请人： Venkata P. Palle ,  Ashwani Verma ,  Rakesh Kumar Singh ,  Yogesh Bhaskarrao Waman ,  Arti Walia ,  Abhijit Ray ,  Geeta Sharma

发明人： Venkata P. Palle ,  Ashwani Verma ,  Rakesh Kumar Singh ,  Yogesh Bhaskarrao Waman ,  Arti Walia ,  Abhijit Ray ,  Geeta Sharma

IPC分类号： C07D487/04 ,  A61K31/519 ,  A61P29/00 ,  A61P19/02 ,  A61P11/00 ,  A61P9/00 ,  A61P3/00 ,  A61P3/10 ,  A61P1/00

CPC分类号： C07D471/04

摘要： The present invention relates to novel azabicyclo derivatives of Formula (I) as anti-inflammatory agents which are useful for inhibition and prevention of inflammation and associated pathologies including inflammatory and autoimmune diseases such as sepsis, rheumatoid arthritis, inflammatory bowel disease, type-1 diabetes, asthma, chronic obstructive pulmonary disorder, organ transplant rejection and psoriasis.

摘要翻译： 本发明涉及式（I）的新型氮杂双环衍生物作为抗炎剂，其可用于抑制和预防炎症和相关病理学，包括炎性和自身免疫疾病如败血症，类风湿性关节炎，炎性肠病，1型糖尿病 ，哮喘，慢性阻塞性肺病，器官移植排斥和牛皮癣。

公开(公告)号：US20090221600A1

公开(公告)日：2009-09-03

申请号：US12088538

申请日：2006-09-28

申请人： Ashwani Kumar Verma ,  Yogesh Bhaskarrao Waman ,  Venkata P. Palle ,  Atul Kondaskar ,  Abhijit Ray ,  Malini Bajpai ,  Geeta Sharma

发明人： Ashwani Kumar Verma ,  Yogesh Bhaskarrao Waman ,  Venkata P. Palle ,  Atul Kondaskar ,  Abhijit Ray ,  Malini Bajpai ,  Geeta Sharma

IPC分类号： A61K31/519 ,  C07D471/04 ,  A61P29/00

CPC分类号： C07D471/04

摘要： Provided are novel pyrido-pyrimidine derivatives, having the structure of Formula (I): which can be used as anti-inflammatory agents. Also provided are pharmaceutical compositions comprising one or more pyrido-pyrimidine derivatives, as well as methods of treating autoimmune diseases, inflammation or associated pathologies, including for example, sepsis, rheumatoid arthritis, inflammatory bowel disease, type-1 diabetes, asthma, chronic obstructive pulmonary disorder, organ transplant rejection and psoriasis, comprising administering such compounds or pharmaceutical compositions comprising them.

摘要翻译： 提供具有式（I）结构的新型吡啶并嘧啶衍生物：其可用作抗炎剂。 还提供了包含一种或多种吡啶并嘧啶衍生物的药物组合物，以及治疗自身免疫性疾病，炎症或相关病理学的方法，包括例如败血症，类风湿性关节炎，炎性肠病，1型糖尿病，哮喘，慢性阻塞性 肺部疾病，器官移植排斥和牛皮癣，包括施用这样的化合物或包含它们的药物组合物。