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    PYRIDO'2,3-DIPYRIMIDINES AS ANTI-INFLAMMATORY AGENTS
    1.
    发明申请
    PYRIDO'2,3-DIPYRIMIDINES AS ANTI-INFLAMMATORY AGENTS 审中-公开
    吡咯烷-2,3-二吡啶作为抗炎剂

    公开(公告)号：US20090131430A1

    公开(公告)日：2009-05-21

    申请号：US11720047

    申请日：2005-11-23

    申请人： Venkata P. Palle ,  Rakesh Kumar Singh ,  Sanjay Malhotra ,  Yogesh Bhaskarrao Waman ,  Ashwani Verma ,  Abhijit Ray ,  Geeta Sharma

    发明人： Venkata P. Palle ,  Rakesh Kumar Singh ,  Sanjay Malhotra ,  Yogesh Bhaskarrao Waman ,  Ashwani Verma ,  Abhijit Ray ,  Geeta Sharma

    IPC分类号： A61K31/5377 ,  C07D471/04 ,  A61P29/00 ,  A61K31/519

    CPC分类号： C07D471/04

    摘要： The present invention relates to novel azabicyclo derivatives as anti-inflammatory agents. The compounds provided herein can be useful for inhibition and prevention of inflammation and associated pathologies including inflammatory and autoimmune diseases such as sepsis, rheumatoid arthritis, inflammatory bowel disease, type-1 diabetes, asthma, chronic obstructive pulmonary disorder, organ transplant rejection and psoriasis. Also provided herein are pharmacological compositions containing compounds provided herein and associated methods of treating sepsis, rheumatoid arthritis, inflammatory bowel disease, type-1 diabetes, asthma, chronic obstructive pulmonary disorder, organ transplant rejection and psoriasis, and other inflammatory and/or autoimmune disorders, using the compounds.

    摘要翻译： 本发明涉及新型的氮杂二环衍生物作为抗炎剂。 本文提供的化合物可用于抑制和预防炎症和相关病理，包括炎性和自身免疫性疾病，例如败血症，类风湿性关节炎，炎性肠病，1型糖尿病，哮喘，慢性阻塞性肺病，器官移植排斥反应和牛皮癣。 本文还提供含有本文提供的化合物的药物组合物和治疗败血症，类风湿性关节炎，炎性肠病，1型糖尿病，哮喘，慢性阻塞性肺病，器官移植排斥反应和牛皮癣以及其它炎性和/或自身免疫性疾病的相关方法 ，使用该化合物。

    MONOSACCHARIDE DERIVATIVES
    4.
    发明申请
    MONOSACCHARIDE DERIVATIVES 失效
    单糖衍生物

    公开(公告)号：US20070287673A1

    公开(公告)日：2007-12-13

    申请号：US11755164

    申请日：2007-05-30

    申请人： Ashwani Verma ,  Sanjay Malhotra ,  Sankaranarayanan Dharmarajan ,  Abhijit Ray ,  Rajkumar Shirumalla

    发明人： Ashwani Verma ,  Sanjay Malhotra ,  Sankaranarayanan Dharmarajan ,  Abhijit Ray ,  Rajkumar Shirumalla

    IPC分类号： A61K31/7008

    CPC分类号： C07H13/12 ,  C07H9/04

    摘要： The present invention relates to monosaccharide derivatives as anti-inflammatory agents. The compounds disclosed herein can be useful for inhibition and prevention of inflammation and associated pathologies including inflammatory and autoimmune diseases such as bronchial asthma, rheumatoid arthritis, type I diabetes, multiple sclerosis, allograft rejection, psoriasis, inflammatory bowel disease, ulcerative colitis, acne, atherosclerosis, cancer, pruritis and allergic rhinitis. Pharmacological compositions containing compounds disclosed herein and the methods of treating bronchial asthma, chronic obstructive pulmonary disease, rheumatoid arthritis, multiple sclerosis, type I diabetes, psoriasis, allograft rejection, inflammatory bowel disease, ulcerative colitis, acne, atherosclerosis, cancer, pruritis, allergic rhinitis and other inflammatory and/or autoimmune disorders, using the compounds are also provided.

    摘要翻译： 本发明涉及作为抗炎剂的单糖衍生物。 本文公开的化合物可用于抑制和预防炎症和相关病理学，包括炎症和自身免疫性疾病，例如支气管哮喘，类风湿性关节炎，I型糖尿病，多发性硬化，同种异体移植物排斥，牛皮癣，炎性肠病，溃疡性结肠炎，痤疮， 动脉粥样硬化，癌症，瘙痒和过敏性鼻炎。 含有本文公开的化合物的药理学组合物和治疗支气管哮喘，慢性阻塞性肺病，类风湿性关节炎，多发性硬化，I型糖尿病，牛皮癣，同种异体移植排斥，炎性肠病，溃疡性结肠炎，痤疮，动脉粥样硬化，癌症，瘙痒，过敏性 还提供使用该化合物的鼻炎和其它炎性和/或自身免疫性疾病。

    5-LIPOXYGENASE INHIBITORS
    5.
    发明申请
    5-LIPOXYGENASE INHIBITORS 失效
    5-LIPOXYGENASE抑制剂

    公开(公告)号：US20080021080A1

    公开(公告)日：2008-01-24

    申请号：US11685892

    申请日：2007-03-14

    申请人： Ashwani Verma ,  Sanjay Malhotra ,  Abhijit Ray ,  Shirumalla Kumar

    发明人： Ashwani Verma ,  Sanjay Malhotra ,  Abhijit Ray ,  Shirumalla Kumar

    IPC分类号： A61K31/41 ,  A61P11/00 ,  C07D249/00

    CPC分类号： C07D405/12 ,  C07D405/14 ,  C07D413/14

    摘要： The present invention relates to 5-lipoxygenase inhibitors. Compounds disclosed herein can be useful in the treatment of bronchial asthma, chronic obstructive pulmonary disorder, arthritis, type I diabetes, multiple sclerosis, allograft rejection, psoriasis, inflammatory bowel disease, ulcerative colitis, acne, atherosclerosis, cancer, pruritis, urticaria, atopic dermatitis, allergic rhinitis, other inflammatory and autoimmune diseases. Processes for the preparation of disclosed compounds, pharmaceutical compositions containing the disclosed compounds and their use as 5-lipoxygenase inhibitors are also provided.

    摘要翻译： 本发明涉及5-脂氧合酶抑制剂。 本文公开的化合物可用于治疗支气管哮喘，慢性阻塞性肺病，关节炎，I型糖尿病，多发性硬化，同种异体移植排斥，牛皮癣，炎性肠病，溃疡性结肠炎，痤疮，动脉粥样硬化，癌症，瘙痒症，荨麻疹，特应性 皮炎，过敏性鼻炎，其他炎性和自身免疫性疾病。 还提供了制备所公开的化合物的方法，含有所公开的化合物的药物组合物及其作为5-脂氧合酶抑制剂的用途。

    Pyrazolo (3, 4-B) pyridine derivatives as phosphodiesterase inhibitors
    8.
    发明授权
    Pyrazolo (3, 4-B) pyridine derivatives as phosphodiesterase inhibitors 有权
    吡唑并（3,4-B）吡啶衍生物作为磷酸二酯酶抑制剂

    公开(公告)号：US08420666B2

    公开(公告)日：2013-04-16

    申请号：US12531043

    申请日：2008-03-14

    申请人： Sonali Rudra ,  Nidhi Gupta ,  Lalit Kumar Baregama ,  Ritu Agarwal ,  Vinayak Vasantrao Khairnar ,  Mandadapu Raghu Ramaiah ,  Venkata P. Palle ,  Sarala Balachandran ,  Atul Kondaskar ,  Manohar Salla ,  Abhijit Ray ,  Sunanda G. Dastidar ,  Lalitha Vijaykrishnan

    发明人： Sonali Rudra ,  Nidhi Gupta ,  Lalit Kumar Baregama ,  Ritu Agarwal ,  Vinayak Vasantrao Khairnar ,  Mandadapu Raghu Ramaiah ,  Venkata P. Palle ,  Sarala Balachandran ,  Atul Kondaskar ,  Manohar Salla ,  Abhijit Ray ,  Sunanda G. Dastidar ,  Lalitha Vijaykrishnan

    IPC分类号： C07D513/02 ,  C07D515/02 ,  A01N43/42 ,  A61K31/44

    CPC分类号： C07D471/04 ,  C07D519/00

    摘要： The present invention relates to phosphodiesterase (PDE) type 4, phosphodiesterase (PDE) type 7 and dual PDE type 4/PDE type 7 inhibitors. Compounds disclosed herein having the structure of Formula 1: can be useful in the treatment, prevention, inhibition or suppression of CNS diseases, for example, multiple sclerosis; various pathological conditions such as diseases affecting the immune system, including AIDS, rejection of transplant, auto-immune disorders such as T-cell related diseases, for example, rheumatoid arthritis; inflammatory diseases such as respiratory inflammation diseases including chronic obstructive pulmonary disease (COPD), asthma, bronchitis, allergic rhinitis, adult respiratory distress syndrome (ARDS) and other inflammatory diseases including but not limited to psoriasis, shock, atopic dermatitis, eosinophilic granuloma, allergic conjunctivitis, osteoarthritis; gastrointestinal inflammation diseases such as Crohn's disease, colitis, pancreatitis as well as different types of cancers including leukaemia; especially in humans. Processes for the preparation of disclosed compounds, pharmaceutical compositions containing the disclosed compounds and their use as PDE type 4, PDE type 7 and dual PDE type 4/PDE type 7 inhibitors are provided.

    摘要翻译： 本发明涉及磷酸二酯酶（PDE）4型，磷酸二酯酶（PDE）7型和双重PDE型4 / PDE型7型抑制剂。 本文公开的具有式1结构的化合物可用于治疗，预防，抑制或抑制CNS疾病，例如多发性硬化; 各种病理状况如影响免疫系统的疾病，包括艾滋病，移植排斥反应，自身免疫性疾病如T细胞相关疾病，例如类风湿性关节炎; 炎性疾病如呼吸道炎症疾病，包括慢性阻塞性肺疾病（COPD），哮喘，支气管炎，过敏性鼻炎，成人呼吸窘迫综合征（ARDS）和其他炎性疾病，包括但不限于银屑病，休克，特应性皮炎，嗜酸性肉芽肿，过敏性 结膜炎，骨关节炎; 胃肠道炎症性疾病如克罗恩病，结肠炎，胰腺炎以及不同类型的癌症，包括白血病; 特别是在人类。 提供了制备所公开的化合物的方法，含有所公开的化合物的药物组合物及其作为PDE 4型，PDE型7和双重PDE型4 / PDE 7型抑制剂的用途。

    INHIBITORS OF PHOSPHODIESTERASE TYPE-IV
    9.
    发明申请
    INHIBITORS OF PHOSPHODIESTERASE TYPE-IV 审中-公开
    磷酸酯酶类型IV的抑制剂

    公开(公告)号：US20090221566A1

    公开(公告)日：2009-09-03

    申请号：US12090790

    申请日：2006-10-05

    申请人： Venkata P. Palle ,  Sarala Balachandran ,  Sarika Ramnani ,  Abhijit Ray ,  Sunanda G. Dastidar

    发明人： Venkata P. Palle ,  Sarala Balachandran ,  Sarika Ramnani ,  Abhijit Ray ,  Sunanda G. Dastidar

    IPC分类号： A61K31/537 ,  C07D265/02 ,  A61K31/535 ,  A61P25/00 ,  A61P11/06 ,  A61P11/08 ,  A61P17/00 ,  A61P17/06 ,  A61P19/02 ,  A61P19/10

    CPC分类号： C07D265/02

    摘要： The present invention relates to oxazine derivatives, which can be used as selective inhibitors of phosphodiesterase (PDE) type IV. Compounds disclosed herein can be useful in the treatment of CMS disorders, AIDS, asthma, arthritis, bronchitis, chronic obstructive pulmonary disease (COPD), psoriasis, allergic rhinitis, shock, atopic dermatitis, Crohn's disease, adult respiratory distress syndrome (ARDS), eosinophilic granuloma, allergic conjunctivitis, osteoarthritis, ulcerative colitis and other inflammatory diseases especially in humans. Processes for the preparation of disclosed compounds are provided, as well as pharmaceutical compositions containing the disclosed compounds, and their use as phosphodiesterase (PDE) type IV inhibitors.

    摘要翻译： 本发明涉及恶嗪衍生物，其可用作IV型磷酸二酯酶（PDE）的选择性抑制剂。 本文公开的化合物可用于治疗CMS疾病，AIDS，哮喘，关节炎，支气管炎，慢性阻塞性肺疾病（COPD），牛皮癣，过敏性鼻炎，休克，特应性皮炎，克罗恩病，成人呼吸窘迫综合征（ARDS） 嗜酸粒细胞性肉芽肿，过敏性结膜炎，骨关节炎，溃疡性结肠炎和其他炎性疾病，特别是人类。 提供了制备所公开化合物的方法，以及含有所公开化合物的药物组合物及其作为磷酸二酯酶（PDE）IV型抑制剂的用途。

    PYRAZOLO [3, 4-B] PYRIDINE DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS
    10.
    发明申请
    PYRAZOLO [3, 4-B] PYRIDINE DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS 审中-公开
    吡咯并[3,4-B]吡啶衍生物作为磷酸二酯酶抑制剂

    公开(公告)号：US20110130403A1

    公开(公告)日：2011-06-02

    申请号：US12531045

    申请日：2008-03-13

    申请人： Sonali Rudra ,  Nidhi Gupta ,  Lalit Kumar Baregama ,  Ritu Agarwal ,  Mandadapu Raghuramaiah ,  Vinayak Vasantrao Khairnar ,  Venkata P. Palle ,  Sarala Balachandran ,  Abhijit Ray ,  Sunada G. Dastidar ,  Lalitha Vijaykrishnan

    发明人： Sonali Rudra ,  Nidhi Gupta ,  Lalit Kumar Baregama ,  Ritu Agarwal ,  Mandadapu Raghuramaiah ,  Vinayak Vasantrao Khairnar ,  Venkata P. Palle ,  Sarala Balachandran ,  Abhijit Ray ,  Sunada G. Dastidar ,  Lalitha Vijaykrishnan

    IPC分类号： A61K31/437 ,  C07D471/04 ,  A61K31/444 ,  A61K31/497 ,  A61K31/506 ,  A61K31/53 ,  A61P29/00 ,  A61P37/06 ,  A61P25/00

    CPC分类号： C07D471/04

    摘要： The present invention relates to phosphodiesterase (PDE) type 4, phosphodiesterase (PDE) type 7 and dual PDE type 4/PDE type 7 inhibitors. Compounds disclosed hereinf having the structure of Formula I: can be useful in the treatment, prevention, inhibition or suppression of CNS diseases, for example, multiple sclerosis; various pathological conditions such as diseases affecting the immune system, including AIDS, rejection of transplant, auto-immune disorders such as T-cell related diseases, for example, rheumatoid arthritis; inflammatory diseases such as respiratory inflammation diseases including chronic obstructive pulmonary disease (COPD), asthma, bronchitis, allergic rhinitis, adult respiratory distress syndrome (ARDS) and other inflammatory diseases including but not limited to psoriasis, shock, atopic dermatitis, eosinophilic granuloma, allergic conjunctivitis, osteoarthritis; gastrointestinal inflammation diseases such as Crohn's disease, colitis, pancreatitis as well as different types of cancers including leukaemia; especially in humans. Processes for the preparation of disclosed compounds, pharmaceutical compositions containing the disclosed compounds and their use as PDE type 4, PDE type 7 and dual PDE t e 4/PDE t e 7 inhibitors are rovided.

    摘要翻译： 本发明涉及磷酸二酯酶（PDE）4型，磷酸二酯酶（PDE）7型和双重PDE型4 / PDE型7型抑制剂。 本文公开的具有式I结构的化合物可用于治疗，预防，抑制或抑制CNS疾病，例如多发性硬化; 各种病理状况如影响免疫系统的疾病，包括艾滋病，移植排斥反应，自身免疫性疾病如T细胞相关疾病，例如类风湿性关节炎; 炎性疾病如呼吸道炎症疾病，包括慢性阻塞性肺疾病（COPD），哮喘，支气管炎，过敏性鼻炎，成人呼吸窘迫综合征（ARDS）和其他炎性疾病，包括但不限于银屑病，休克，特应性皮炎，嗜酸性肉芽肿，过敏性 结膜炎，骨关节炎; 胃肠道炎症性疾病如克罗恩病，结肠炎，胰腺炎以及不同类型的癌症，包括白血病; 特别是在人类。 制备所公开的化合物的方法，包含所公开的化合物的药物组合物及其作为PDE 4型，PDE型7和双重PDE 4 / PDE 7抑制剂的用途是有争议的。