公开(公告)号：US07258971B2

公开(公告)日：2007-08-21

申请号：US10757262

申请日：2004-01-14

申请人： Venkateswarlu Karicheti ,  Inmaculada Silos-Santiago ,  Scott D. Eliasof

发明人： Venkateswarlu Karicheti ,  Inmaculada Silos-Santiago ,  Scott D. Eliasof

IPC分类号： C12Q1/00 ,  A61K39/00

CPC分类号： C07K14/47

摘要： The present invention relates to methods for the diagnosis and treatment of a urological disorder or urological disorders. Specifically, the present invention identifies the differential expression of Carboxypeptidase Z, identified as “8263” gene in tissues relating to urological disorder, relative to their expression in normal, or non-urological disorder disease states, and/or in response to manipulations relevant to a urological disorder. The present invention describes methods for the diagnostic evaluation and prognosis of various urological diseases, and for the identification of subjects exhibiting a predisposition to such conditions. The invention also provides methods for identifying a compound capable of modulating a urological disorder or urological disorders. The present invention also provides methods for the identification and therapeutic use of compounds as treatments of urological disorders.

摘要翻译： 本发明涉及诊断和治疗泌尿系统疾病或泌尿系统疾病的方法。 具体而言，本发明鉴定了相对于在正常或非泌尿疾病疾病状态下的表达，和/或响应于与泌尿系疾病相关的操作相关的与泌尿系疾病相关的组织中鉴定为“8263”基因的羧肽酶Z的差异表达 泌尿系统疾病 本发明描述了各种泌尿疾病的诊断评估和预后的方法，以及用于鉴定表现出这种病症倾向的受试者。 本发明还提供了鉴定能够调节泌尿系统疾病或泌尿系统疾病的化合物的方法。 本发明还提供了用于鉴定和治疗性使用化合物作为泌尿系统疾病治疗的方法。

公开(公告)号：US07169751B2

公开(公告)日：2007-01-30

申请号：US10768158

申请日：2004-01-30

申请人： Inmaculada Silos-Santiago ,  Venkateswarlu Karicheti ,  Scott D. Eliasof

发明人： Inmaculada Silos-Santiago ,  Venkateswarlu Karicheti ,  Scott D. Eliasof

IPC分类号： G01N33/15 ,  G01N33/483 ,  A61K38/16

CPC分类号： G01N33/6893 ,  C07K16/286 ,  G01N2333/68

摘要： We claim a methods for identifying a compound capable of treating a pain or a painful disorder state comprising combining the test compound with the polypeptide of SEQ ID NO:2, and detecting binding of said test compound to said polypeptide thereby identifying a compound that binds to said polypeptide.

摘要翻译： 我们要求一种用于鉴定能够治疗疼痛或疼痛障碍状态的化合物的方法，包括将测试化合物与SEQ ID NO：2的多肽组合，并检测所述测试化合物与所述多肽的结合，从而鉴定与 所述多肽。