公开(公告)号：US20140309413A1

公开(公告)日：2014-10-16

申请号：US14203332

申请日：2014-03-10

申请人： Vertex Pharmaceuticals Incorporated

发明人： Peter Jamison Rose ,  Young Chun Jung ,  Cavan McKeon Bligh ,  Shereen Ibrahim ,  Luigi Anzalone ,  David B. Miller, JR. ,  John Gregg Van Alsten ,  Timothy Thomas Curran

IPC分类号： C07H1/02 ,  C07F9/58 ,  C07H19/10

CPC分类号： C07H1/02 ,  C07F9/20 ,  C07F9/242 ,  C07F9/26 ,  C07F9/58 ,  C07F9/65586 ,  C07H19/10

摘要： The present invention relates to the novel diastereoselective syntheses for generating phosphorothioate compounds. Examples include nucleoside phosphorothioate analogs that are useful in treating diseases and/or conditions such as viral infections.

摘要翻译： 本发明涉及用于产生硫代磷酸酯化合物的新的非对映选择性合成。 实例包括可用于治疗疾病和/或病症如病毒感染的核苷硫代磷酸酯类似物。

公开(公告)号：US20180065962A1

公开(公告)日：2018-03-08

申请号：US15807877

申请日：2017-11-09

申请人： Vertex Pharmaceuticals Incorporated

发明人： Luc J. Farmer ,  Michael John Boyd ,  David B. Miller, JR. ,  Valerie Ann Cwynar

IPC分类号： C07D471/04

CPC分类号： C07D471/04 ,  C07D239/42

摘要： A method of preparing a compound of Formula (I) or a pharmaceutically acceptable salt thereof: comprises: (a) reacting Compound (1): or a pharmaceutically acceptable salt thereof with Compound (2): in the presence of water, an organic solvent, a base, and a transition metal catalyst to generate a compound of Formula (I) or a pharmaceutically acceptable salt thereof.