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公开(公告)号：US10039761B2
公开(公告)日：2018-08-07
申请号：US15130266
申请日：2016-04-15
发明人： Kwame Wiredu Nti-Addae , Simon Adam O'Neil , Yuegang Zhang , Michael Waldo , Praveen Mudunuri , Bin Song , John Gregg Van Alsten , Mark Strohmeier , Kathy Stavropoulos , Irina Nikolaevna Kadiyala , Mettachit Navamal
IPC分类号： A61K31/33 , A61K31/506 , C07D401/14 , A61K31/337 , A61K31/5025 , A61K31/513 , A61K31/517 , A61K31/555 , A61K31/704 , A61K31/7048 , A61K33/24 , A61K38/14 , A61K39/395 , A61K45/06 , C07B59/00 , C07C55/10 , C07C55/14 , C07C57/145 , C07C57/15 , C07C59/265 , C07C63/08 , C07K16/28 , A61N5/10
CPC分类号： A61K31/506 , A61K31/337 , A61K31/5025 , A61K31/513 , A61K31/517 , A61K31/555 , A61K31/704 , A61K31/7048 , A61K33/24 , A61K38/14 , A61K39/39558 , A61K45/06 , A61N2005/1098 , A61P35/00 , C07B59/002 , C07B2200/05 , C07B2200/13 , C07C55/10 , C07C55/14 , C07C57/145 , C07C57/15 , C07C59/265 , C07C63/08 , C07D401/14 , C07K16/2863 , C07K2317/24
摘要： The present invention relates to compositions and co-crystals each comprising a compound of formula I having the structure: wherein each of R1 and R2 is H or 2H and a co-crystal former selected from adipic acid, citric acid, fumaric acid, maleic acid, succinic acid, or benzoic acid. Also within the scope of this invention are methods of making and using the same.
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公开(公告)号：US20160339024A1
公开(公告)日：2016-11-24
申请号：US15130266
申请日：2016-04-15
发明人： Kwame Wiredu Nti-Addae , Simon Adam O'Neil , Yuegang Zhang , Michael Waldo , Praveen Mudunuri , Bin Song , John Gregg Van Alsten , Mark Strohmeier , Kathy Stavropoulos , Irina Nikolaevna Kadiyala , Mettachit Navamal
IPC分类号： A61K31/506 , C07D401/14 , C07B59/00 , C07C55/14 , C07C55/10 , C07C57/145 , C07C57/15 , C07C59/265 , C07C63/08 , A61K31/337 , A61K31/555 , A61K31/517 , A61K31/7048 , A61K31/704 , A61K38/14 , A61K31/5025 , A61K33/24 , A61K31/513 , A61K39/395 , C07K16/28 , A61K45/06
CPC分类号： A61K31/506 , A61K31/337 , A61K31/5025 , A61K31/513 , A61K31/517 , A61K31/555 , A61K31/704 , A61K31/7048 , A61K33/24 , A61K38/14 , A61K39/39558 , A61K45/06 , A61N2005/1098 , C07B59/002 , C07B2200/05 , C07B2200/13 , C07C55/10 , C07C55/14 , C07C57/145 , C07C57/15 , C07C59/265 , C07C63/08 , C07D401/14 , C07K16/2863 , C07K2317/24
摘要： The present invention relates to compositions and co-crystals each comprising a compound of formula I having the structure: wherein each of R1 and R2 is H or 2H and a co-crystal former selected from adipic acid, citric acid, fumaric acid, maleic acid, succinic acid, or benzoic acid. Also within the scope of this invention are methods of making and using the same.
摘要翻译： 其中R1和R2各自为H或2H，选自己二酸，柠檬酸，富马酸，马来酸，琥珀酸或苯甲酸的共晶体形成剂。 在本发明的范围内也是制造和使用本发明的方法。
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公开(公告)号：US20180325897A1
公开(公告)日：2018-11-15
申请号：US16038696
申请日：2018-07-18
发明人： Kwame Wiredu Nti-Addae , Simon Adam O'Neil , Yuegang Zhang , Michael Waldo , Praveen Mudunuri , Bin Song , John Gregg Van Alsten , Mark Strohmeier , Kathy Stavropoulos , Irina Nikolaevna Kadiyala , Mettachit Navamal
IPC分类号： A61K31/506 , C07K16/28 , A61K31/5025 , A61K31/513 , A61K31/517 , A61K31/337 , C07D401/14 , C07C63/08 , C07C59/265 , C07C57/15 , C07C57/145 , C07C55/14 , C07C55/10 , C07B59/00 , A61K45/06 , A61K39/395 , A61K38/14 , A61K33/24 , A61K31/7048 , A61K31/704 , A61K31/555 , A61N5/10
摘要： The present invention relates to compositions and co-crystals each comprising a compound of formula I having the structure: wherein each of R1 and R2 is H or 2H and a co-crystal former selected from adipic acid, citric acid, fumaric acid, maleic acid, succinic acid, or benzoic acid. Also within the scope of this invention are methods of making and using the same.
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公开(公告)号：US20160251353A1
公开(公告)日：2016-09-01
申请号：US15150459
申请日：2016-05-10
发明人： Kwame W. Nti-Addae , Michael Waldo , Simon Adam O'Neil , John Gregg Van Alsten , Dainius Macikenas , Praveen Mudunuri , Yi Shi , Mark Willem Ledeboer , Valdas Jurkauskas , Ales Medek , Steven Jones , Randal Byrn , Mohammed Asmal , Sarah Marie Robertson , Wanjung Tsai
IPC分类号： C07D471/04 , A61K45/06 , A61K31/4965 , A61K31/16 , A61K31/351 , A61K31/506 , C07C309/30
CPC分类号： C07D471/04 , A61K31/16 , A61K31/351 , A61K31/4965 , A61K31/506 , A61K45/06 , C07C309/30 , C07D403/04
摘要： Polymorphic forms of Compound (1) or a pharmaceutically acceptable salt thereof, wherein Compound (1) is represented by the following structural formula: are Form A of HCl salt of Compound (1).½H2O, Form F of HCl salt of Compound (1).3H2O, Form D of HCl salt of Compound (1), Form A of Compound (1), and Form A of tosylate salt of Compound (1). Such polymorphic forms are employed for treating influenza, inhibiting the replication of influenza viruses, or reducing the amount of influenza viruses in a biological sample or in a subject.
摘要翻译： 化合物（1）的多晶型或其药学上可接受的盐，其中化合物（1）由以下结构式表示：化合物（1）的HCl盐的形式A。化合物（1）的HCl盐的形式F ）.3H 2 O，化合物（1）的HCl盐的形式D，化合物（1）的形式A和化合物（1）的甲苯磺酸盐的形式A. 这种多晶型用于治疗流感，抑制流感病毒的复制，或减少生物样品或受试者中流感病毒的数量。
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公开(公告)号：US10716789B2
公开(公告)日：2020-07-21
申请号：US16038696
申请日：2018-07-18
发明人： Kwame Wiredu Nti-Addae , Simon Adam O'Neil , Yuegang Zhang , Michael P. Waldo , Praveen Mudunuri , Bin Song , John Gregg Van Alsten , Mark Strohmeier , Kathy Stavropoulos , Irina Nikolaevna Kadiyala , Mettachit Navamal
IPC分类号： A61K31/506 , C07D401/14 , A61P35/00 , A61K31/337 , A61K31/5025 , A61K31/513 , A61K31/517 , A61K31/555 , A61K31/704 , A61K31/7048 , A61K33/24 , A61K38/14 , A61K39/395 , A61K45/06 , C07B59/00 , C07C55/10 , C07C55/14 , C07C57/145 , C07C57/15 , C07C59/265 , C07C63/08 , C07K16/28 , A61N5/10
摘要： The present invention relates to compositions and co-crystals each comprising a compound of formula I having the structure: wherein each of R1 and R2 is H or 2H and a co-crystal former selected from adipic acid, citric acid, fumaric acid, maleic acid, succinic acid, or benzoic acid. Also within the scope of this invention are methods of making and using the same.
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公开(公告)号：US09771361B2
公开(公告)日：2017-09-26
申请号：US15150459
申请日：2016-05-10
发明人： Kwame W. Nti-Addae , Michael Waldo , Simon Adam O'Neil , John Gregg Van Alsten , Dainius Macikenas , Praveen Mudunuri , Yi Shi , Mark Willem Ledeboer , Valdas Jurkauskas , Ales Medek , Steven Jones , Randal Byrn , Mohammed Asmal , Sarah Marie Robertson , Wanjung Tsai
IPC分类号： C07D471/04 , C07D403/04 , A61K31/506 , A61K31/16 , A61K31/351 , A61K31/4965 , A61K45/06 , C07C309/30
CPC分类号： C07D471/04 , A61K31/16 , A61K31/351 , A61K31/4965 , A61K31/506 , A61K45/06 , C07C309/30 , C07D403/04
摘要： Polymorphic forms of Compound (1) or a pharmaceutically acceptable salt thereof, wherein Compound (1) is represented by the following structural formula: are Form A of HCl salt of Compound (1).½H2O, Form F of HCl salt of Compound (1).3H2O, Form D of HCl salt of Compound (1), Form A of Compound (1), and Form A of tosylate salt of Compound (1). Such polymorphic forms are employed for treating influenza, inhibiting the replication of influenza viruses, or reducing the amount of influenza viruses in a biological sample or in a subject.
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7.发明申请公开(公告)号：US20140309413A1
公开(公告)日：2014-10-16
申请号：US14203332
申请日：2014-03-10
发明人： Peter Jamison Rose , Young Chun Jung , Cavan McKeon Bligh , Shereen Ibrahim , Luigi Anzalone , David B. Miller, JR. , John Gregg Van Alsten , Timothy Thomas Curran
摘要： The present invention relates to the novel diastereoselective syntheses for generating phosphorothioate compounds. Examples include nucleoside phosphorothioate analogs that are useful in treating diseases and/or conditions such as viral infections.
摘要翻译： 本发明涉及用于产生硫代磷酸酯化合物的新的非对映选择性合成。 实例包括可用于治疗疾病和/或病症如病毒感染的核苷硫代磷酸酯类似物。
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