专利检索 ap:("Vertex Pharmaceuticals Incorporated") AND inv:"Kevin James GAGNON" 第 1 页

1.

发明申请
SOLID FORMS OF APOL1 INHIBITORS AND METHODS OF USING SAME 有权

公开(公告)号：US20230119114A1

公开(公告)日：2023-04-20

申请号：US17895582

申请日：2022-08-25

申请人： Vertex Pharmaceuticals Incorporated

发明人： Kevin Brett DANIEL , Lori Ann FERRIS , Kevin James GAGNON , Michael David JUDELSON , Mei-Hsiu LAI , Courtney K. MAGUIRE , Ales MEDEK , Andrey PERESYPKIN , Peter Jamison ROSE , Yi SHI , Charlene TSAY

IPC分类号： C07D495/20 , B01J23/46

摘要： The disclosure provides novel solid state forms of Compound I chosen from Compound I Phosphate Salt Hydrate Form A, Compound I free form Monohydrate, Compound I Phosphate Salt Methanol Solvate, and Compound I Phosphate Salt MEK Solvate, compositions comprising the same, and methods of making and using the same, including uses in treating APOL1 mediated disease (such as, e.g., APOL1 mediated kidney disease). Also provided herein are novel solid state forms of Compound II chosen from Compound II Phosphate Salt Hemihydrate Form A, Compound II free form Hemihydrate Form A, and Compound II free form Form C, compositions comprising the same, and methods of making and using the same, including uses in treating APOL1 mediated disease (such as, e.g., APOL1 mediated kidney disease).

2.

发明公开
MODULATORS OF ALPHA-1 ANTITRYPSIN 审中-公开

公开(公告)号：US20240336614A1

公开(公告)日：2024-10-10

申请号：US18487690

申请日：2023-10-16

申请人： Vertex Pharmaceuticals Incorporated

发明人： Upul Keerthi BANDARAGE , Cavan McKeon BLIGH , Diane BOUCHER , Michael John BOYD , Michael Aaron BRODNEY , Michael Philip CLARK , Veronique DAMAGNEZ , Lev Tyler Dewey FANNING , Robert Francis FIMOGNARI , Gabrielle Simone FLEMING , Kevin James GAGNON , Pedro Manuel GARCIA BARRANTES , Robert Daniel GIACOMETTI , Simon GIROUX , Ronald Lee GREY, JR. , Samantha GUIDO , Amy Beth HALL , Sarah Carol HOOD , Dennis James HURLEY , Mac Arthur JOHNSON, JR. , Peter Jones , Sarathy KESAVAN , Mei-Hsiu LAI , Siying LIU , Adam LOOKER , Brad MAXWELL , John Patrick MAXWELL , Ales MEDEK , Philippe Marcel NUHANT , Kirk Alan OVERHOFF , Setu RODAY , Stefanie ROEPER , Steven M. RONKIN , Rupa SAWANT , Yi SHI , Muna SHRESTHA , Marisa SPOSATO , Kathy STAVROPOULOS , Rebecca Jane SWETT , Timothy Lewis TAPLEY , Qing TANG , Stephen THOMSON , Jinwang XU , Mariam ZAKY , Kevin Michael COTTRELL

IPC分类号： C07D487/04 , A61K9/16 , A61K31/4162 , C07D491/18 , C07D513/04 , C07D519/00 , C07F9/6561 , C07H15/26

CPC分类号： C07D487/04 , A61K9/1635 , A61K9/1652 , A61K31/4162 , C07D491/18 , C07D513/04 , C07D519/00 , C07F9/6561 , C07H15/26 , C07B2200/13

摘要： The disclosure provides compounds useful for treating alpha-1 antitrypsin deficiency (AATD), according to formula (I):

tautomers thereof, pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable salts of the tautomers, deuterated derivatives of the compounds, deuterated derivatives of the tautomers, and deuterated derivatives of the salts, solid forms of those compounds and processes for making those compounds.

3.

发明公开
SOLID FORMS OF APOL1 INHIBITOR AND METHODS OF USING SAME 审中-公开

公开(公告)号：US20230250087A1

公开(公告)日：2023-08-10

申请号：US18001371

申请日：2021-06-11

申请人： VERTEX PHARMACEUTICALS INCORPORATED

发明人： Kevin James GAGNON , Jicong LI , Ales MEDEK , Jack Raphael MINCHOM , Yi SHI , Muna SHRESTHA , Faith WITKOS

IPC分类号： C07D403/12

CPC分类号： C07D403/12 , C07B2200/13

摘要： The disclosure provides novel solid state forms of Compound I selected from ethanol solvate Form A, ethanol solvate Form B, citric acid cocrystal Form A, and Form B, compositions comprising the same, and methods of making and using the same, including use in treating APOL1 mediated kidney disease. (I).