公开(公告)号：US10738030B2

公开(公告)日：2020-08-11

申请号：US16089703

申请日：2017-03-31

申请人： Vertex Pharmaceuticals Incorporated

发明人： Brian Bear ,  Jeremy Clemens ,  Thomas Cleveland ,  Timothy Richard Coon ,  Peter Diederik Jan Grootenhuis ,  Bryan A. Frieman ,  Sara S. Hadida Ruah ,  Haripada Khatuya ,  Paul J. Krenitsky ,  Mark Thomas Miller ,  Alina Silina ,  Johnny Uy ,  Jinglan Zhou

IPC分类号： C07D401/14 ,  C07D213/82 ,  A61P11/00 ,  C07D401/12 ,  C07D471/04

摘要： The present disclosure features a compound of formula I: or a pharmaceutically acceptable salt thereof, where R1, R2, W, X, Z, n, p, and Rings A and B are defined herein, for the treatment of CFTR mediated diseases, such as cystic fibrosis. The present disclosure also features pharmaceutical compositions, method of treating, and kits thereof.

公开(公告)号：US20190055220A1

公开(公告)日：2019-02-21

申请号：US16089703

申请日：2017-03-31

申请人： Vertex Pharmaceuticals Incorporated

发明人： Brian Bear ,  Jeremy Clemens ,  Thomas Cleveland ,  Timothy Richard Coon ,  Peter Diederik Jan Grootenhuis ,  Bryan A. Frieman ,  Sara S. Hadida Ruah ,  Haripada Khatuya ,  Paul J. Krenitsky ,  Mark Thomas Miller ,  Alina Silina ,  Johnny Uy ,  Jinglan Zhou

IPC分类号： C07D401/14 ,  C07D401/12 ,  C07D471/04 ,  A61P11/00

CPC分类号： C07D401/14 ,  A61P11/00 ,  C07D213/82 ,  C07D401/12 ,  C07D471/04

摘要： The present disclosure features a compound of formula I: or a pharmaceutically acceptable salt thereof, where R1, R2, W, X, Z, n, p, and Rings A and B are defined herein, for the treatment of CFTR mediated diseases, such as cystic fibrosis. The present disclosure also features pharmaceutical compositions, method of treating, and kits thereof.