公开(公告)号：US20230286961A1

公开(公告)日：2023-09-14

申请号：US17982983

申请日：2022-11-08

申请人： Vertex Pharmaceuticals Incorporated

发明人： Steven John Durrant ,  Nadia M. Ahmad ,  Elizabeth Mary Beck ,  Lidio Marx Carvalho Meireles ,  Ewa Iwona Chudyk ,  Gorka Etxebarria Jardi ,  Bhairavi Galan ,  Sara S. Hadida Ruah ,  Dennis James Hurley ,  Ronald Marcellus Knegtel ,  Timothy Donald Neubert ,  Joanne Louise Pinder ,  Joseph Pontillo ,  Robert Pullin ,  Yvonne Schmidt ,  David Matthew Shaw ,  Sarah Skerratt ,  Dean Stamos ,  Stephen Andrew Thomson ,  Anisa Nizarali Virani ,  Christopher Wray

IPC分类号： C07D405/12 ,  C07D405/14 ,  C07D307/24

CPC分类号： C07D405/12 ,  C07D307/24 ,  C07D405/14 ,  C07B2200/13

摘要： Compounds, and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including pain.

公开(公告)号：US20240182455A1

公开(公告)日：2024-06-06

申请号：US18491021

申请日：2023-10-20

申请人： VERTEX PHARMACEUTICALS INCORPORATED

发明人： Elizabeth Mary Beck ,  Steven John Durrant ,  Sarah Skerratt ,  Robert Pullin ,  Gorka Etxebarria Jardi ,  David Matthew Shaw ,  Nadia M. Ahmad ,  Christopher Wray ,  Anisa Nizarali Virani ,  Kiri North ,  James Dodd ,  Michael Edward O'Donnell ,  Bhairavi Galan ,  Ronald Marcellus Knegtel ,  Ewa Iwona Chudyk ,  Joanne Louise Pinder ,  Stephen Andrew Thomson ,  Lidio Marx Carvalho Meireles ,  Dean Stamos ,  Yvonne Schmidt ,  Joseph Pontillo ,  Sara S. Hadida Ruah ,  Timothy Donald Neubert ,  Dennis James Hurley ,  Jinglan Zhou

IPC分类号： C07D405/12

CPC分类号： C07D405/12

摘要： Compounds, and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including pain.

公开(公告)号：US11834441B2

公开(公告)日：2023-12-05

申请号：US17112156

申请日：2020-12-04

申请人： Vertex Pharmaceuticals Incorporated

发明人： Steven John Durrant ,  Nadia Ahmad ,  Elizabeth Mary Beck ,  Lidio Marx Carvalho Meireles ,  Ewa Iwona Chudyk ,  Gorka Etxebarria Jardi ,  Bhairavi Galan ,  Sara S. Hadida Ruah ,  Dennis James Hurley ,  Ronald Marcellus Knegtel ,  Timothy Donald Neubert ,  Joanne Louise Pinder ,  Joseph Pontillo ,  Robert Pullin ,  Yvonne Schmidt ,  David Matthew Shaw ,  Sarah Skerratt ,  Dean Stamos ,  Stephen Andrew Thomson ,  Anisa Nizarali Virani ,  Christopher Wray

IPC分类号： C07D405/12 ,  C07D307/24 ,  C07D405/14

CPC分类号： C07D405/12 ,  C07D307/24 ,  C07D405/14 ,  C07B2200/13

摘要： Compounds, and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including pain.

公开(公告)号：US11919887B2

公开(公告)日：2024-03-05

申请号：US17982983

申请日：2022-11-08

申请人： Vertex Pharmaceuticals Incorporated

发明人： Steven John Durrant ,  Nadia M. Ahmad ,  Elizabeth Mary Beck ,  Lidio Marx Carvalho Meireles ,  Ewa Iwona Chudyk ,  Gorka Etxebarria Jardi ,  Bhairavi Galan ,  Sara S. Hadida Ruah ,  Dennis James Hurley ,  Ronald Marcellus Knegtel ,  Timothy Donald Neubert ,  Joanne Louise Pinder ,  Joseph Pontillo ,  Robert Pullin ,  Yvonne Schmidt ,  David Matthew Shaw ,  Sarah Skerratt ,  Dean Stamos ,  Stephen Andrew Thomson ,  Anisa Nizarali Virani ,  Christopher Wray

IPC分类号： C07D307/24 ,  C07D405/12 ,  C07D405/14

CPC分类号： C07D405/12 ,  C07D307/24 ,  C07D405/14 ,  C07B2200/13

摘要： Compounds, and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including pain.

公开(公告)号：US11827627B2

公开(公告)日：2023-11-28

申请号：US17831842

申请日：2022-06-03

申请人： VERTEX PHARMACEUTICALS INCORPORATED

发明人： Elizabeth Mary Beck ,  Steven John Durrant ,  Sarah Skerratt ,  Robert Pullin ,  Gorka Etxebarria Jardi ,  David Matthew Shaw ,  Nadia M. Ahmad ,  Christopher Wray ,  Anisa Nizarali Virani ,  Kiri North ,  James Dodd ,  Michael Edward O'Donnell ,  Bhairavi Galan ,  Ronald Marcellus Knegtel ,  Ewa Iwona Chudyk ,  Joanne Louise Pinder ,  Stephen Andrew Thomson ,  Lidio Marx Carvalho Meireles ,  Dean Stamos ,  Yvonne Schmidt ,  Joseph Pontillo ,  Sara S. Hadida Ruah ,  Timothy Donald Neubert ,  Dennis James Hurley ,  Jinglan Zhou

IPC分类号： C07D405/12

CPC分类号： C07D405/12

摘要： Compounds, and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including pain.