公开(公告)号：US20100305639A1

公开(公告)日：2010-12-02

申请号：US12836784

申请日：2010-07-15

申请人： Victor T. Chen ,  David S. Wood ,  Milton M. Morris

发明人： Victor T. Chen ,  David S. Wood ,  Milton M. Morris

IPC分类号： A61N1/365 ,  A61N1/368

CPC分类号： A61N1/3622

摘要： A system and method which employs atrial discrimination algorithms to distinguish between different atrial arrhythmias occurring in a patient for selecting an optimal pacing therapy corresponding to the type of arrhythmia identified. In response to the detection of an atrial rate above the atrial tracking rate, discrimination criteria are applied to a detected atrial activity signal to distinguish between different types of supraventricular tachycardia, such as fast atrial flutter and other atrial flutter at a relatively slower rate, which may be occurring in the patient. The pacer is controlled to provide pacing therapy to a heart in a manner corresponding to the type of supraventricular tachycardia identified. The output of an atrial discrimination algorithm may be tracked and the trend thereof used to improve therapy timing. Various embodiments are disclosed herein.

摘要翻译： 一种使用心房辨别算法来区分患者发生的不同心房心律不齐的系统和方法，用于选择对应于确定的心律失常类型的最佳起搏治疗。 响应于心房率高于心房跟踪率的检测，将鉴别标准应用于检测到的心房活动信号，以区别不同类型的室上性心动过速，例如以较慢速率的快速心房扑动和其他心房扑动，其中 可能发生在患者身上。 控制起搏器以对应于所鉴定的室上性心动过速类型的方式向心脏提供起搏治疗。 可以跟踪心房辨别算法的输出，并且其趋势用于改善治疗时机。 本文公开了各种实施例。

公开(公告)号：US06978177B1

公开(公告)日：2005-12-20

申请号：US09712600

申请日：2000-11-14

申请人： Victor T. Chen ,  David S. Wood ,  Milton M. Morris

发明人： Victor T. Chen ,  David S. Wood ,  Milton M. Morris

IPC分类号： A61N1/362 ,  A61N1/368

CPC分类号： A61N1/3622

摘要： A system and method which employs atrial discrimination algorithms to distinguish between different atrial arrhythmias occurring in a patient for selecting an optimal pacing therapy corresponding to the type of arrhythmia identified. The invention may be implemented in a bradycardia pacemaker or other implantable cardiac device. In response to the detection of an atrial rate above the atrial tracking rate, discrimination criteria are applied to a detected atrial activity signal to distinguish between different types of supraventricular tachycardia, such as fast atrial flutter and other atrial flutter at a relatively slower rate, which may be occurring in the patient. The discrimination criteria may be, for example, rate-based or morphology based. The pacer is controlled to provide pacing therapy to a heart in a manner corresponding to the type of supraventricular tachycardia identified. For example, antitachycardia pacing may be provided to the heart in response to the detection of a relatively lower rate supraventricular tachycardia/other atrial flutter, whereas another pacing control, e.g., ventricular pacing, such as ventricular rate regulation or Rate Smoothing, may be applied if a more rapid rate supraventricular tachycardia/fast atrial flutter is identified. The output of an atrial discrimination algorithm may be tracked and the trend thereof used to improve therapy timing.

摘要翻译： 一种使用心房辨别算法来区分患者发生的不同心房心律不齐的系统和方法，用于选择对应于确定的心律失常类型的最佳起搏治疗。 本发明可以在心动过缓起搏器或其他可植入的心脏装置中实现。 响应于心房率高于心房跟踪率的检测，将鉴别标准应用于检测到的心房活动信号，以区别不同类型的室上性心动过速，例如以较慢速率的快速心房扑动和其他心房扑动，其中 可能发生在患者身上。 歧视标准可以是例如基于速率或基于形态的。 控制起搏器以对应于所鉴定的室上性心动过速类型的方式向心脏提供起搏治疗。 例如，可以响应于检测相对较低的室上性心动过速/其他心房扑动而向心脏提供抗心动过速起搏，而可以应用另一起搏控制，例如心室起搏，例如心室速率调节或速率平滑 如果确定更快速的室上性心动过速/快速心房扑动。 可以跟踪心房辨别算法的输出，并且其趋势用于改善治疗时机。

公开(公告)号：US07764997B2

公开(公告)日：2010-07-27

申请号：US11266955

申请日：2005-11-04

申请人： Victor T. Chen ,  David S. Wood ,  Milton M. Morris

发明人： Victor T. Chen ,  David S. Wood ,  Milton M. Morris

IPC分类号： A61N1/00

CPC分类号： A61N1/3622

摘要： A system and method which employs atrial discrimination algorithms to distinguish between different atrial arrhythmias occurring in a patient for selecting an optimal pacing therapy corresponding to the type of arrhythmia identified. In response to the detection of an atrial rate above the atrial tracking rate, discrimination criteria are applied to a detected atrial activity signal to distinguish between different types of supraventricular tachycardia, such as fast atrial flutter and other atrial flutter at a relatively slower rate, which may be occurring in the patient. The pacer is controlled to provide pacing therapy to a heart in a manner corresponding to the type of supraventricular tachycardia identified. The output of an atrial discrimination algorithm may be tracked and the trend thereof used to improve therapy timing. Various embodiments are disclosed herein.

摘要翻译： 一种使用心房辨别算法来区分患者发生的不同心房心律不齐的系统和方法，用于选择对应于确定的心律失常类型的最佳起搏治疗。 响应于心房率高于心房跟踪率的检测，将鉴别标准应用于检测到的心房活动信号，以区别不同类型的室上性心动过速，例如以较慢速率的快速心房扑动和其他心房扑动，其中 可能发生在患者身上。 控制起搏器以对应于所鉴定的室上性心动过速类型的方式向心脏提供起搏治疗。 可以跟踪心房辨别算法的输出，并且其趋势用于改善治疗时机。 本文公开了各种实施例。

公开(公告)号：US20080319494A1

公开(公告)日：2008-12-25

申请号：US12229563

申请日：2008-08-25

申请人： Victor T. Chen ,  Gary T. Seim ,  Milton M. Morris

发明人： Victor T. Chen ,  Gary T. Seim ,  Milton M. Morris

IPC分类号： A61N1/362

CPC分类号： A61N1/3962 ,  A61N1/3622

摘要： A system and method for providing pacing pulses after a cardioversion/defibrillation shock, where the pacing pulses have a pacing rate at an initial value. The pacing rate is decreased from the initial value until at least one intrinsic cardiac contraction is detected. In one embodiment, the pacing rate is decreased by a set amount after pacing a set number of cardiac cycles. Providing the set number of pacing pulses and decreasing the pacing rate by the set amount is then repeated until at least one intrinsic cardiac contraction is detected. An intrinsic cardiac rate is then determined from the at least one intrinsic cardiac contraction. The pacing rate is then increased and maintained to be above (i.e., greater than) the intrinsic cardiac rate.

摘要翻译： 用于在心脏复律/除颤休克之后提供起搏脉冲的系统和方法，其中起搏脉冲具有初始值的起搏速率。 起搏速率从初始值降低到检测到至少一个固有心脏收缩。 在一个实施例中，起搏速率在起搏设定数量的心动周期后降低设定量。 然后重复提供设定数量的起搏脉冲并将起搏速率降低设定量，直到检测到至少一个固有心脏收缩。 然后从至少一个固有心脏收缩确定固有心率。 然后起搏速率增加并保持在高于（即大于）本征心率。

公开(公告)号：US08046061B2

公开(公告)日：2011-10-25

申请号：US12229563

申请日：2008-08-25

申请人： Victor T. Chen ,  Gary T. Seim ,  Milton M. Morris

发明人： Victor T. Chen ,  Gary T. Seim ,  Milton M. Morris

IPC分类号： A61N1/39

CPC分类号： A61N1/3962 ,  A61N1/3622

摘要： A system and method for providing pacing pulses after a cardioversion/defibrillation shock, where the pacing pulses have a pacing rate at an initial value. The pacing rate is decreased from the initial value until at least one intrinsic cardiac contraction is detected. In one embodiment, the pacing rate is decreased by a set amount after pacing a set number of cardiac cycles. Providing the set number of pacing pulses and decreasing the pacing rate by the set amount is then repeated until at least one intrinsic cardiac contraction is detected. An intrinsic cardiac rate is then determined from the at least one intrinsic cardiac contraction. The pacing rate is then increased and maintained to be above (i.e., greater than) the intrinsic cardiac rate.

摘要翻译： 用于在心脏复律/除颤休克之后提供起搏脉冲的系统和方法，其中起搏脉冲具有初始值的起搏速率。 起搏速率从初始值降低到检测到至少一个固有心脏收缩。 在一个实施例中，起搏速率在起搏设定数量的心动周期后降低设定量。 然后重复提供设定数量的起搏脉冲并将起搏速率降低设定量，直到检测到至少一个固有心脏收缩。 然后从至少一个固有心脏收缩确定固有心率。 然后起搏速率增加并保持在高于（即大于）本征心率。

公开(公告)号：US06829504B1

公开(公告)日：2004-12-07

申请号：US09662091

申请日：2000-09-14

申请人： Victor T. Chen ,  Gary T. Seim ,  Milton M. Morris

发明人： Victor T. Chen ,  Gary T. Seim ,  Milton M. Morris

IPC分类号： A61N139

CPC分类号： A61N1/3962 ,  A61N1/3622

摘要： A system and method for providing pacing pulses after a cardioversion/defibrillation shock, where the pacing pulses have a pacing rate at an initial value. The pacing rate is decreased from the initial value until at least one intrinsic cardiac contraction is detected. In one embodiment, the pacing rate is decreased by a set amount after pacing a set number of cardiac cycles. Providing the set number of pacing pulses and decreasing the pacing rate by the set amount is then repeated until at least one intrinsic cardiac contraction is detected. An intrinsic cardiac rate is then determined from the at least one intrinsic cardiac contraction. The pacing rate is then increased and maintained to be above (i.e., greater than) the intrinsic cardiac rate.

摘要翻译： 用于在心脏复律/除颤休克之后提供起搏脉冲的系统和方法，其中起搏脉冲具有初始值的起搏速率。 起搏速率从初始值降低到检测到至少一个固有心脏收缩。 在一个实施例中，起搏速率在起搏设定数量的心动周期后降低设定量。 然后重复提供设定数量的起搏脉冲并将起搏速率降低设定量，直到检测到至少一个固有心脏收缩。 然后从至少一个固有心脏收缩确定固有心率。 然后起搏速率增加并保持在高于（即大于）本征心率。

公开(公告)号：US07421294B2

公开(公告)日：2008-09-02

申请号：US10975553

申请日：2004-10-28

申请人： Victor T. Chen ,  Gary T. Seim ,  Milton M. Morris

发明人： Victor T. Chen ,  Gary T. Seim ,  Milton M. Morris

IPC分类号： A61N1/362

CPC分类号： A61N1/3962 ,  A61N1/3622

摘要： A system and method for providing pacing pulses after a cardioversion/defibrillation shock, where the pacing pulses have a pacing rate at an initial value. The pacing rate is decreased from the initial value until at least one intrinsic cardiac contraction is detected. In one embodiment, the pacing rate is decreased by a set amount after pacing a set number of cardiac cycles. Providing the set number of pacing pulses and decreasing the pacing rate by the set amount is then repeated until at least one intrinsic cardiac contraction is detected. An intrinsic cardiac rate is then determined from the at least one intrinsic cardiac contraction. The pacing rate is then increased and maintained to be above (i.e., greater than) the intrinsic cardiac rate.

公开(公告)号：US07740623B2

公开(公告)日：2010-06-22

申请号：US11159752

申请日：2005-06-23

申请人： Asha S. Nayak ,  Matthew D. Bonner ,  Paul T. Rothstein ,  Prasanga D. Hiniduma-Lokuge ,  James R. Keogh ,  Raymond W. Usher ,  Scott E. Jahns ,  Victor T. Chen

发明人： Asha S. Nayak ,  Matthew D. Bonner ,  Paul T. Rothstein ,  Prasanga D. Hiniduma-Lokuge ,  James R. Keogh ,  Raymond W. Usher ,  Scott E. Jahns ,  Victor T. Chen

IPC分类号： A61M31/00 ,  A61M37/00

CPC分类号： A61B17/205 ,  A61B17/00491 ,  A61B17/0206 ,  A61B17/3478 ,  A61B2017/00247 ,  A61B2017/0243 ,  A61B2017/2936 ,  A61B2017/2939 ,  A61B2017/2943 ,  A61B2017/306 ,  A61B2018/00392 ,  A61M5/32 ,  A61M25/0084

摘要： The current invention discloses a method for treating infracted/ischemic injury to a myocardium by injecting a substance into the myocardium. The injected substance helps to prevent negative adaptive remodeling by providing mechanical reinforcement or mechanical reinforcement combined with biological therapy. A number of substances for injection are disclosed, including multi component substances such as platelet gel, and other substances. The substances disclosed may contain additives to augment/enhance the desired effects of the injection. The invention also discloses devices used to inject the substances. The devices can include means for ensuring needles do not penetrate beyond a desired depth into the myocardium. The devices can also include needles having multiple lumens such that the components of the platelet gel will be combined at the injection site and begin polymerization in the myocardium.

摘要翻译： 本发明公开了一种通过将物质注入心肌来治疗心肌缺血/缺血损伤的方法。 注射的物质通过提供结合生物治疗的机械加强或机械增强物有助于防止负性适应性重塑。 公开了许多注射用物质，包括多成分物质如血小板凝胶和其他物质。 所公开的物质可以含有增加/增强注射效果的添加剂。 本发明还公开了用于注入物质的装置。 该装置可以包括用于确保针不超过心肌内的所需深度的装置。 该装置还可以包括具有多个内腔的针，使得血小板凝胶的组分将在注射部位组合并开始在心肌中聚合。

公开(公告)号：US07024240B2

公开(公告)日：2006-04-04

申请号：US10643513

申请日：2003-08-19

申请人： Victor T. Chen ,  Gary T. Seim ,  Carlos Ricci ,  Michael L. Favet ,  Hal Propp

发明人： Victor T. Chen ,  Gary T. Seim ,  Carlos Ricci ,  Michael L. Favet ,  Hal Propp

IPC分类号： A61N1/39

CPC分类号： A61N1/3956

摘要： An implantable cardiac device detects a patient therapy request originating from external to the implantable device. A shock therapy delay period is timed in response to the detection of the patient therapy request. Atrial shock therapy is provided to the patient after expiration of the shock therapy delay period (if the presence of an ongoing atrial arrhythmia is detected). The patient therapy request may be provided by a patient activator including a magnet for operating a reed switch in the implanted device to provide the request. A patient activator including an input and receiver/transmitter circuitry may be employed to request the immediate providing of atrial shock therapy, and/or to set the duration the shock therapy delay period. By allowing specific delays to therapy after a therapy request, a patient can prepare for the requested therapy and thereby mitigate therapy discomfort.

公开(公告)号：US06618617B2

公开(公告)日：2003-09-09

申请号：US09839123

申请日：2001-04-20

申请人： Victor T. Chen ,  Gary T. Seim ,  Carlos Ricci ,  Michael L. Favet ,  Hal Propp

发明人： Victor T. Chen ,  Gary T. Seim ,  Carlos Ricci ,  Michael L. Favet ,  Hal Propp

IPC分类号： A61N139

CPC分类号： A61N1/3956

摘要： An implantable cardiac device detects a patient therapy request originating from external to the implantable device. A shock therapy delay period is timed in response to the detection of the patient therapy request. Atrial shock therapy is provided to the patient after expiration of the shock therapy delay period (if the presence of an ongoing atrial arrhythmia is detected). The patient therapy request may be provided by a patient activator including a magnet for operating a reed switch in the implanted device to provide the request. A patient activator including an input and receiver/transmitter circuitry may be employed to request the immediate providing of atrial shock therapy, and/or to set the duration of the shock therapy delay period. By allowing specific delays to therapy after a therapy request, a patient can prepare for the requested therapy and thereby mitigate therapy discomfort.