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    Multistage process for the preparation of highly pure deferoxamine mesylate salt
    5.
    发明授权
    Multistage process for the preparation of highly pure deferoxamine mesylate salt 失效
    用于制备高纯度去铁胺甲磺酸盐的多步法

    公开(公告)号：US06858414B2

    公开(公告)日：2005-02-22

    申请号：US10168042

    申请日：2000-11-30

    申请人： Vilmos Keri ,  Zoltan Czovek ,  Attila Mezo

    发明人： Vilmos Keri ,  Zoltan Czovek ,  Attila Mezo

    IPC分类号： C07C259/06 ,  C12P13/02 ,  B01D15/08 ,  C07C259/04 ,  C07C309/00 ,  C12P13/00

    CPC分类号： C07C259/06

    摘要： The present invention provides a purification process whereby deferoxamine B produced by a microorganism and in mixture with other polyhydroxamates produced by the microorganism may be converted into its mesylate salt substantially free of the other polyhydroxamates and substantially free of chloride ion. The process includes adsorption and desorption of the deferoxamine B on an adsorption resin, direct precipitation of the deferoxamine free base out of the eluent from the adsorption resin, contacting of the deferoxamine B free base with methanesulfonic acid and isolation of the deferoxamine B mesylate salt by precipitation. This process minimizes decomposition of deferoxamine B.

    摘要翻译： 本发明提供了一种纯化方法，其中由微生物产生的去铁胺B与由微生物产生的其它多羟基羟胺化合物混合可以转化为基本上不含其它多羟基异羟酸酯并基本上不含氯离子的甲磺酸盐。 该方法包括去铁胺B在吸附树脂上的吸附和解吸，从吸附树脂中将脱铁胺游离碱从洗脱液中直接沉淀出，脱铁胺B游离碱与甲磺酸接触，并通过以下步骤分离去铁胺B甲磺酸盐： 沉淀。 该方法使去铁胺B的分解最小化

    Method of purifying macrolides
    8.
    发明申请
    Method of purifying macrolides 审中-公开
    大环内酯类的纯化方法

    公开(公告)号：US20060149057A1

    公开(公告)日：2006-07-06

    申请号：US11317152

    申请日：2005-12-22

    申请人： Vilmos Keri ,  Zoltan Czovek

    发明人： Vilmos Keri ,  Zoltan Czovek

    IPC分类号： C07D267/22 ,  C07D281/18

    CPC分类号： B01J20/285 ,  B01D15/426 ,  C07D267/22 ,  C07D281/18 ,  C07D498/18

    摘要： A method for purifying macrolide is provided in which a loading charge of macrolide is placed in juxtaposition with a bed of wet sorption resin, the loading charge and bed are eluted at a temperature greater than 30° C. with an eluent of an organic solvent selected from the group consisting of THF, acetonitrile, n-propyl alcohol, iso-propyl alcohol, ethyl alcohol, and acetone, the heart cut of the eluent is collected, and purified macrolide is collected.

    摘要翻译： 提供了一种用于纯化大环内酯的方法，其中将大环内酯的负载量与湿吸附树脂床并置放置，加载装料和床在大于30℃的温度下用选择的有机溶剂的洗脱液洗脱 从由THF，乙腈，正丙醇，异丙醇，乙醇和丙酮组成的组中，收集洗脱液的心脏切片，并收集纯化的大环内酯。