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1.发明申请公开(公告)号：US20100286269A1
公开(公告)日：2010-11-11
申请号：US12740700
申请日：2008-11-03
CPC分类号： A61K31/20 , A61K31/23 , A61K45/06 , A61K2300/00
摘要： Use of medium-chain length fatty acids such as capric acid, caprylic acid or lauric acid and their salts or mono- or di- or triglycerides as nephroprotection agents to protect against renal failure progression in chronic kidney diseases This includes the treatment of kidney diseases associated with nephrectomy, renal fibrosis, glomerular scelrosis and end-stage renal disease Also includes the protection of the kidney against cytotoxic agent used in chemotherapy or autoimmune diseases or transplantation Further includes the treatment of renal failure progression associated with hypertension, infarct, tumour, diabetes mellitus, autoimmunity or inflammation.
摘要翻译： 使用中链长度脂肪酸如癸酸，辛酸或月桂酸及其盐或单 - 或二 - 或甘油三酸酯作为肾保护剂，以防止慢性肾脏疾病中的肾衰竭进展这包括治疗肾脏疾病相关 肾切除术，肾纤维化，肾小球结肠炎和终末期肾脏疾病还包括对化疗或自身免疫性疾病或移植中使用的细胞毒性剂的肾脏保护进一步包括治疗与高血压，梗塞，肿瘤，糖尿病相关的肾衰竭进展 ，自身免疫或炎症。
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2.发明授权公开(公告)号：US09532962B2
公开(公告)日：2017-01-03
申请号：US12740700
申请日：2008-11-03
CPC分类号： A61K31/20 , A61K31/23 , A61K45/06 , A61K2300/00
摘要： Use of medium-chain length fatty acids such as capric acid, caprylic acid or lauric acid and their salts or mono- or di- or triglycerides as nephroprotection agents to protect against renal failure progression in chronic kidney diseases This includes the treatment of kidney diseases associated with nephrectomy, renal fibrosis, glomerular sclerosis and end-stage renal disease Also includes the protection of the kidney against cytotoxic agent used in chemotherapy or autoimmune diseases or transplantation Further includes the treatment of renal failure progression associated with hypertension, infarct, tumor, diabetes mellitus, autoimmunity or inflammation.
摘要翻译： 使用中链长度脂肪酸如癸酸，辛酸或月桂酸及其盐或单 - 或二 - 或甘油三酸酯作为肾保护剂，以防止慢性肾脏疾病中的肾衰竭进展这包括治疗肾脏疾病相关 肾切除术，肾纤维化，肾小球硬化和终末期肾脏疾病还包括对化疗或自身免疫性疾病或移植中使用的细胞毒性剂的肾脏保护进一步包括治疗与高血压，梗塞，肿瘤，糖尿病有关的肾衰竭进展 ，自身免疫或炎症。
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3.发明授权Semi-permeable microcapsule with covalently linked layers and method for producing same 失效具有共价连接层的半透性微胶囊及其制备方法公开(公告)号：US07128931B2
公开(公告)日：2006-10-31
申请号：US10686789
申请日：2003-10-17
IPC分类号： A61K9/50
CPC分类号： B01J13/22 , A61K9/5073 , A61K35/39 , B01J13/14
摘要： The present invention relates to semi-permeable microcapsules, which exhibit an increased resistance to mechanical stresses as well as an increased resistance to chemical degradation. More specifically, this semi-permeable microcapsule has a bead enclosing a material such as living cells, covalently linked to a semi-permeable layer, made of a polycation cross-linking derivative, covering the bead. The present invention is also directed to a pharmaceutical composition comprising the above-mentioned semi-permeable microcapsules. The present invention is also directed to the use of such microcapsule in a method for microencapsulating a beaded material and in a method for treating diabetes in a subject.
摘要翻译： 本发明涉及半透性微胶囊，其表现出对机械应力的增加的抗性以及对化学降解的增加的抗性。 更具体地说，这种半透性微胶囊具有包围诸如活细胞的珠，该珠粒与聚阳离子交联衍生物共轭连接到半透膜上，覆盖珠。 本发明还涉及包含上述半透性微胶囊的药物组合物。 本发明还涉及这样的微胶囊在微胶囊化珠粒材料的方法中的用途以及用于治疗受试者的糖尿病的方法。
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4.发明申请Semi-permeable microcapsule with covalently linked layers and method for producing same 失效具有共价连接层的半透性微胶囊及其制备方法公开(公告)号：US20050147594A1
公开(公告)日：2005-07-07
申请号：US10686789
申请日：2003-10-17
CPC分类号： B01J13/22 , A61K9/5073 , A61K35/39 , B01J13/14
摘要： The present invention relates to semi-permeable microcapsules, which exhibit an increased resistance to mechanical stresses as well as an increased resistance to chemical degradation. More specifically, this semi-permeable microcapsule has a bead enclosing a material such as living cells, covalently linked to a semi-permeable layer, made of a polycation cross-linking derivative, covering the bead. The present invention is also directed to a pharmaceutical composition comprising the above-mentioned semi-permeable microcapsules. The present invention is also directed to the use of such microcapsule in a method for microencapsulating a beaded material and in a method for treating diabetes in a subject.
摘要翻译： 本发明涉及半透性微胶囊，其表现出对机械应力的增加的抗性以及对化学降解的增加的抗性。 更具体地说，这种半透性微胶囊具有包围诸如活细胞的珠，该珠粒与聚阳离子交联衍生物共轭连接到半透膜上，覆盖珠。 本发明还涉及包含上述半透性微胶囊的药物组合物。 本发明还涉及这样的微胶囊在微胶囊化珠粒材料的方法中的用途以及用于治疗受试者的糖尿病的方法。
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