公开(公告)号：US08946254B2

公开(公告)日：2015-02-03

申请号：US14371075

申请日：2013-01-10

Applicant: Virginia Commonwealth University

Inventor： Yan Zhang ,  Kurt F. Hauser ,  Dana E. Selley

IPC: A61K31/485 ,  C07D489/08

CPC classification number: A61K47/481 ,  A61K31/485 ,  A61K47/55 ,  C07D489/08 ,  A61K2300/00

Abstract: Bivalent ligands that contain two pharmacophores linked through a spacer, one of which interacts with the μ-opioid receptor (MOR) and the other of which interacts with the co-receptor CC chemokine receptor 5 (CCR5), are used for the treatment of neurological disorders such as those associated with AIDS.

公开(公告)号：US20140357656A1

公开(公告)日：2014-12-04

申请号：US14371075

申请日：2013-01-10

Applicant: Virginia Commonwealth University

Inventor： Yan Zhang ,  Kurt F. Hauser ,  Dana E. Selley

IPC: C07D489/08 ,  A61K31/485

CPC classification number: A61K47/481 ,  A61K31/485 ,  A61K47/55 ,  C07D489/08 ,  A61K2300/00

Abstract: Bivalent ligands that contain two pharmacophores linked through a spacer, one of which interacts with the μ-opioid receptor (MOR) and the other of which interacts with the co-receptor CC chemokine receptor 5 (CCR5), are used for the treatment of neurological disorders such as those associated with AIDS.

Abstract translation: 含有通过间隔基连接的两个药效团的二价配体，其中一个与μ-阿片受体（MOR）相互作用，另一个与辅助受体CC趋化因子受体5（CCR5）相互作用）用于治疗神经系统 诸如与艾滋病相关的疾病。

公开(公告)号：US09107954B2

公开(公告)日：2015-08-18

申请号：US14568859

申请日：2014-12-12

Applicant: Virginia Commonwealth University

Inventor： Yan Zhang ,  Kurt F. Hauser ,  Dana E. Selley

IPC: A61K31/485 ,  A61K47/48

CPC classification number: A61K47/481 ,  A61K31/485 ,  A61K47/55 ,  C07D489/08 ,  A61K2300/00

Abstract: Bivalent ligands that contain two pharmacophores linked through a spacer, one of which interacts with the μ-opioid receptor (MOR) and the other of which interacts with the co-receptor CC chemokine receptor 5 (CCR5), are used for the treatment of neurological disorders such as those associated with AIDS.

Abstract translation: 含有通过间隔基连接的两个药效团的二价配体，其中一个与μ-阿片受体（MOR）相互作用，另一个与辅助受体CC趋化因子受体5（CCR5）相互作用）用于治疗神经系统 诸如与艾滋病相关的疾病。

公开(公告)号：US20150157730A1

公开(公告)日：2015-06-11

申请号：US14568859

申请日：2014-12-12

Applicant: Virginia Commonwealth University

Inventor： Yan Zhang ,  Kurt F. Hauser ,  Dana E. Selley

IPC: A61K47/48 ,  A61K31/485

CPC classification number: A61K47/481 ,  A61K31/485 ,  A61K47/55 ,  C07D489/08 ,  A61K2300/00

Abstract: Bivalent ligands that contain two pharmacophores linked through a spacer, one of which interacts with the μ-opioid receptor (MOR) and the other of which interacts with the co-receptor CC chemokine receptor 5 (CCR5), are used for the treatment of neurological disorders such as those associated with AIDS.

Abstract translation: 含有通过间隔基连接的两个药效团的二价配体，其中一个与μ-阿片受体（MOR）相互作用，另一个与辅助受体CC趋化因子受体5（CCR5）相互作用）用于治疗神经系统 诸如与艾滋病相关的疾病。