公开(公告)号：US11607537B2

公开(公告)日：2023-03-21

申请号：US16210771

申请日：2018-12-05

Applicant: Virginia Tech Intellectual Properties, Inc. ,  VoltMed, Inc.

Inventor： Eduardo Latouche ,  Samuel Lesko ,  Lucy Epshteyn ,  Christopher B. Arena ,  John H. Rossmeisl, Jr. ,  Melvin Lorenzo ,  Rafael Davalos

IPC: A61B18/08 ,  A61N1/05 ,  A61N1/32 ,  A61N1/37 ,  A61N1/36 ,  A61B18/14 ,  A61B18/00 ,  A61N1/08

Abstract: This disclosure describes the methods, devices, and systems of treating diseased tissue with integrated nanosecond pulse irreversible electroporation. Methods and systems as disclosed provide MRI compatible shielded electrodes and electrode leads to prevent emanating radiofrequency noise and improve image quality, disconnecting the electrode from the cable linkage to the pulse generator reduce electromagnetic interference and image artifacts, placing electrodes strategically within a guide cannula to minimize distortion from heterogeneities or maximize ablation within the tissue, utilizing conductive fluids, innate or external, such as cerebral spinal fluid or grounding pads to provide a pathway for current return, and for timing of the electrical waveforms with inherent brain electrical activity.

公开(公告)号：US12214189B2

公开(公告)日：2025-02-04

申请号：US16938778

申请日：2020-07-24

Applicant: Virginia Tech Intellectual Properties, Inc. ,  Angio Dynamics, Inc.

Inventor： Melvin F. Lorenzo ,  Christopher B. Arena ,  Suyashree Bhonsle ,  Natalie White ,  Lucy Epshteyn ,  Rafael V. Davalos

IPC: A61B18/12 ,  A61N1/08 ,  A61N1/32 ,  A61B17/00 ,  A61B18/00

Abstract: Electroporation-based therapies (EBTs) employ high voltage pulsed electric fields (PEFs) to permeabilize tumor tissue, resulting in changes in passive electrical properties detectable using electrical impedance spectroscopy (EIS). Currently, commercial potentiostats for EIS are limited by impedance spectrum acquisition time (˜10 s); this timeframe is much larger than pulse periods used with EBTs (˜1 s). Fourier Analysis SpecTroscopy (FAST) is introduced as a methodology for monitoring tissue inter-burst impedance (diagnostic FAST) and intra-burst impedance (therapeutic FAST) during EBTs. FAST is a rapid-capture (

公开(公告)号：US20210023362A1

公开(公告)日：2021-01-28

申请号：US16938778

申请日：2020-07-24

Applicant: Virginia Tech Intellectual Properties, Inc.

Inventor： Melvin F. Lorenzo ,  Christopher B. Arena ,  Suyashree Bhonsle ,  Natalie White ,  Lucy Epshteyn ,  Rafael V. Davalos

IPC: A61N1/08 ,  A61N1/32 ,  A61B18/12

Abstract: Electroporation-based therapies (EBTs) employ high voltage pulsed electric fields (PEFs) to permeabilize tumor tissue, resulting in changes in passive electrical properties detectable using electrical impedance spectroscopy (EIS). Currently, commercial potentiostats for EIS are limited by impedance spectrum acquisition time (˜10 s); this timeframe is much larger than pulse periods used with EBTs (˜1 s). Fourier Analysis SpecTroscopy (FAST) is introduced as a methodology for monitoring tissue inter-burst impedance (diagnostic FAST) and intra-burst impedance (therapeutic FAST) during EBTs. FAST is a rapid-capture (