公开(公告)号：US20210393312A1

公开(公告)日：2021-12-23

申请号：US17277662

申请日：2019-09-18

Applicant: Virginia Tech Intellectual Properties, Inc.

Inventor： Rafael V. Davalos ,  Natalie White

IPC: A61B18/12

Abstract: Described herein are methods and systems of performing immunotherapy on a subject and/or determining if a subject will be responsive to ablation immunotherapy.

公开(公告)号：US20210023362A1

公开(公告)日：2021-01-28

申请号：US16938778

申请日：2020-07-24

Applicant: Virginia Tech Intellectual Properties, Inc.

Inventor： Melvin F. Lorenzo ,  Christopher B. Arena ,  Suyashree Bhonsle ,  Natalie White ,  Lucy Epshteyn ,  Rafael V. Davalos

IPC: A61N1/08 ,  A61N1/32 ,  A61B18/12

Abstract: Electroporation-based therapies (EBTs) employ high voltage pulsed electric fields (PEFs) to permeabilize tumor tissue, resulting in changes in passive electrical properties detectable using electrical impedance spectroscopy (EIS). Currently, commercial potentiostats for EIS are limited by impedance spectrum acquisition time (˜10 s); this timeframe is much larger than pulse periods used with EBTs (˜1 s). Fourier Analysis SpecTroscopy (FAST) is introduced as a methodology for monitoring tissue inter-burst impedance (diagnostic FAST) and intra-burst impedance (therapeutic FAST) during EBTs. FAST is a rapid-capture (

公开(公告)号：US20240268878A1

公开(公告)日：2024-08-15

申请号：US18402231

申请日：2024-01-02

Applicant: Virginia Tech Intellectual Properties, Inc.

Inventor： Rafael V. Davalos ,  Natalie White

IPC: A61B18/12 ,  A61B18/00

CPC classification number: A61B18/1206 ,  A61B2018/00577 ,  A61B2018/00613 ,  A61B2018/00827 ,  A61B2018/00875 ,  A61B2018/00892 ,  A61B2018/126

Abstract: Described herein are methods and systems of performing immunotherapy on a subject and/or determining if a subject will be responsive to ablation immunotherapy.

公开(公告)号：US12214189B2

公开(公告)日：2025-02-04

申请号：US16938778

申请日：2020-07-24

Applicant: Virginia Tech Intellectual Properties, Inc. ,  Angio Dynamics, Inc.

Inventor： Melvin F. Lorenzo ,  Christopher B. Arena ,  Suyashree Bhonsle ,  Natalie White ,  Lucy Epshteyn ,  Rafael V. Davalos

IPC: A61B18/12 ,  A61N1/08 ,  A61N1/32 ,  A61B17/00 ,  A61B18/00

Abstract: Electroporation-based therapies (EBTs) employ high voltage pulsed electric fields (PEFs) to permeabilize tumor tissue, resulting in changes in passive electrical properties detectable using electrical impedance spectroscopy (EIS). Currently, commercial potentiostats for EIS are limited by impedance spectrum acquisition time (˜10 s); this timeframe is much larger than pulse periods used with EBTs (˜1 s). Fourier Analysis SpecTroscopy (FAST) is introduced as a methodology for monitoring tissue inter-burst impedance (diagnostic FAST) and intra-burst impedance (therapeutic FAST) during EBTs. FAST is a rapid-capture (

公开(公告)号：US11925405B2

公开(公告)日：2024-03-12

申请号：US17277662

申请日：2019-09-18

Applicant: Virginia Tech Intellectual Properties, Inc.

Inventor： Rafael V. Davalos ,  Natalie White

IPC: A61B18/12 ,  A61B18/00

CPC classification number: A61B18/1206 ,  A61B2018/00577 ,  A61B2018/00613 ,  A61B2018/00827 ,  A61B2018/00875 ,  A61B2018/00892 ,  A61B2018/126

Abstract: Described herein are methods and systems of performing immunotherapy on a subject and/or determining if a subject will be responsive to ablation immunotherapy.