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公开(公告)号：US10470822B2
公开(公告)日：2019-11-12
申请号：US15011752
申请日：2016-02-01
发明人： Paulo A. Garcia , Rafael V. Davalos
摘要： The invention provides for a system for estimating a 3-dimensional treatment volume for a device that applies treatment energy through a plurality of electrodes defining a treatment area, the system comprising a memory, a display device, a processor coupled to the memory and the display device, and a treatment planning module stored in the memory and executable by the processor. In one embodiment, the treatment planning module is adapted to generate an estimated first 3-dimensional treatment volume for display in the display device based on the ratio of a maximum conductivity of the treatment area to a baseline conductivity of the treatment area. The invention also provides for a method for estimating 3-dimensional treatment volume, the steps of which are executable through the processor. In embodiments, the system and method are based on a numerical model which may be implemented in computer readable code which is executable through a processor.
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公开(公告)号：US20190133671A1
公开(公告)日：2019-05-09
申请号：US16232962
申请日：2018-12-26
摘要： Methods for treating tissue with irreversible electroporation and immunotherapy are described. The methods include placing a probe in tissue within a human body, wherein the probe has at least a first electrode, applying a plurality of electrical pulses through the first electrode and a second electrode, causing irreversible electroporation (IRE) of the tissue within a target ablation zone, and administering one or more exogenous agents into the tissue within the target ablation zone or to the human, thereby stimulating or otherwise modulating an immune system response within the body.
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3.发明授权System and method for estimating a treatment volume for administering electrical-energy based therapies 有权用于估计用于施用基于电能的治疗的治疗体积的系统和方法公开(公告)号：US09283051B2
公开(公告)日：2016-03-15
申请号：US14012832
申请日：2013-08-28
发明人： Paulo A. Garcia , Rafael V. Davalos
CPC分类号： A61B18/1206 , A61B18/14 , A61B18/1477 , A61B18/18 , A61B34/10 , A61B2018/0016 , A61B2018/00577 , A61B2018/00613 , A61B2018/00666 , A61B2018/00672 , A61B2018/00678 , A61B2018/00767 , A61B2018/00875 , A61B2018/1425 , A61B2034/104 , C12N13/00
摘要： The invention provides for a system for estimating a 3-dimensional treatment volume for a device that applies treatment energy through a plurality of electrodes defining a treatment area, the system comprising a memory, a display device, a processor coupled to the memory and the display device, and a treatment planning module stored in the memory and executable by the processor. In one embodiment, the treatment planning module is adapted to generate an estimated first 3-dimensional treatment volume for display in the display device based on the ratio of a maximum conductivity of the treatment area to a baseline conductivity of the treatment area. The invention also provides for a method for estimating 3-dimensional treatment volume, the steps of which are executable through the processor. In embodiments, the system and method are based on a numerical model which may be implemented in computer readable code which is executable through a processor.
摘要翻译： 本发明提供一种用于估计通过定义治疗区域的多个电极施加治疗能量的装置的三维治疗体积的系统，所述系统包括存储器，显示装置，耦合到存储器和显示器的处理器 设备和存储在存储器中并由处理器执行的治疗计划模块。 在一个实施例中，治疗计划模块适于基于治疗区域的最大电导率与治疗区域的基线电导率的比率来生成用于在显示装置中显示的估计的第一3维治疗体积。 本发明还提供了一种用于估计三维处理量的方法，该方法的步骤可通过处理器执行。 在实施例中，系统和方法基于可以在可通过处理器执行的计算机可读代码中实现的数值模型。
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公开(公告)号：US20150164584A1
公开(公告)日：2015-06-18
申请号：US14627046
申请日：2015-02-20
发明人： Rafael V. Davalos , Paulo A. Garcia , John L. Robertson , John H. Rossmeisl , Robert E. Neal, II
CPC分类号： A61B18/1477 , A61B18/1206 , A61B2018/00446 , A61B2018/00613 , A61N1/05 , A61N1/327 , C12N13/00
摘要： The present invention provides methods, devices, and systems for in vivo treatment of cell proliferative disorders. Included is a method of treating tissue with electrical energy, the method comprising: delivering electrical energy to tissue using one or more electroporation devices comprising one or more electrodes; and cooling the tissue, surrounding tissue, one or more of the electrodes, or one or more of the electroporation devices to minimize heating. In embodiments, the invention can be used to treat solid tumors, such as brain tumors, and in some embodiments, exemplary methods rely on non-thermal irreversible electroporation (IRE) to cause cell death in treated tumors.
摘要翻译： 本发明提供用于体内治疗细胞增殖性疾病的方法，装置和系统。 包括用电能处理组织的方法，所述方法包括：使用包括一个或多个电极的一个或多个电穿孔装置将电能传送到组织; 以及冷却组织，周围组织，一个或多个电极或一个或多个电穿孔装置以使加热最小化。 在实施方案中，本发明可用于治疗实体瘤，例如脑肿瘤，并且在一些实施方案中，示例性方法依赖于非热不可逆电穿孔（IRE）以在治疗的肿瘤中引起细胞死亡。
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公开(公告)号：US11519877B2
公开(公告)日：2022-12-06
申请号：US16058478
申请日：2018-08-08
IPC分类号： B03C5/00 , B03C5/02 , G01N27/447 , B01D57/02
摘要： Devices and methods for performing dielectrophoresis are described. The devices contain sample channel which is separated by physical barriers from electrode channels which receive electrodes. The devices and methods may be used for the separation and analysis of particles in solution, including the separation and isolation of cells of a specific type. As the electrodes do not make contact with the sample, electrode fouling is avoided and sample integrity is better maintained.
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公开(公告)号：US11453873B2
公开(公告)日：2022-09-27
申请号：US16535451
申请日：2019-08-08
发明人： Rafael V. Davalos , Paulo A. Garcia , John H. Rossmeisl , John L. Robertson , Robert E. Neal, II
摘要： The present invention provides systems, methods, and devices for electroporation-based therapies (EBTs). Embodiments provide patient-specific treatment protocols derived by the numerical modeling of 3D reconstructions of target tissue from images taken of the tissue, and optionally accounting for one or more of physical constraints or dynamic tissue properties. The present invention further relates to systems, methods, and devices for delivering bipolar electric pulses for irreversible electroporation exhibiting reduced or no damage to tissue typically associated with an EBT-induced excessive charge delivered to the tissue.
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公开(公告)号：US11272979B2
公开(公告)日：2022-03-15
申请号：US16152743
申请日：2018-10-05
摘要： Systems and methods are provided for modeling and for providing a graphical representation of tissue heating and electric field distributions for medical treatment devices that apply electrical treatment energy through one or a plurality of electrodes. In embodiments, methods comprise: providing one or more parameters of a treatment protocol for delivering one or more electrical pulses to tissue through a plurality of electrodes; modeling electric and heat distribution in the tissue based on the parameters; and displaying a graphical representation of the modeled electric and heat distribution. In another embodiment, a treatment planning module is adapted to generate an estimated target ablation zone based on a combination of one or more parameters for an irreversible electroporation protocol and one or more tissue-specific conductivity parameters.
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公开(公告)号：US20210393312A1
公开(公告)日：2021-12-23
申请号：US17277662
申请日：2019-09-18
发明人： Rafael V. Davalos , Natalie White
IPC分类号： A61B18/12
摘要： Described herein are methods and systems of performing immunotherapy on a subject and/or determining if a subject will be responsive to ablation immunotherapy.
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9.发明申请公开(公告)号：US20200260987A1
公开(公告)日：2020-08-20
申请号：US16865031
申请日：2020-05-01
发明人： Rafael V. Davalos , Mohammad Bonakdar , Eduardo L. Latouche , Roop L. Mahajan , John L. Robertson , Christopher B. Arena , Michael B. Sano
IPC分类号： A61B5/053
摘要： Provided herein are devices, systems, and methods for monitoring lesion or treated area in a tissue during focal ablation or cell membrane disruption therapy.
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公开(公告)号：US10471254B2
公开(公告)日：2019-11-12
申请号：US15310114
申请日：2015-05-12
申请人： Virginia Tech Intellectual Properties, Inc. , Michael B. Sano , Christopher B. Arena , Scott S. Verbridge , Rafael V. Davalos
IPC分类号： A61B18/14 , A61N1/32 , A61N1/40 , A61B90/00 , A61B18/12 , A61N1/06 , A61N1/08 , A61B18/00 , A61B17/00
摘要： A system and method for selectively treating aberrant cells such as cancer cells through administration of a train of electrical pulses is described. The pulse length and delay between successive pulses is optimized to produce effects on intracellular membrane potentials. Therapies based on the system and method produce two treatment zones: an ablation zone surrounding the electrodes within which aberrant cells are non-selectively killed and a selective treatment zone surrounding the ablation zone within which target cells are selectively killed through effects on intracellular membrane potentials. As a result, infiltrating tumor cells within a tumor margin can be effectively treated while sparing healthy tissue. The system and method are useful for treating various cancers in which solid tumors form and have a chance of recurrence from microscopic disease surrounding the tumor.
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