公开(公告)号：US20240142382A1

公开(公告)日：2024-05-02

申请号：US18280452

申请日：2022-03-04

Applicant: Virginia Tech Intellectual Properties, Inc.

Inventor： Wei ZHOU ,  Wonil NAM

IPC: G01N21/65 ,  G01N33/483

CPC classification number: G01N21/658 ,  G01N33/4833 ,  G01N2201/06113

Abstract: In one aspect, the disclosure relates to methods of label-free surface-enhanced Raman spectroscopy (SERS) comprising plasmonically enhanced electronic Raman scattering (ERS) signals from metal nanostructures as an internal calibration standard to improve multivariate analysis of living biological systems, and the uses of the methods therein. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

公开(公告)号：US20220299444A1

公开(公告)日：2022-09-22

申请号：US17677797

申请日：2022-02-22

Applicant: Virginia Tech Intellectual Properties, Inc.

Inventor： Aditya GARG ,  Wei ZHOU

IPC: G01N21/65 ,  G01J3/44

Abstract: Methods are provided for making a membrane or textile having a mechanically robust surface-enhanced Raman spectroscopy (SERS) substrate by in a first step adhesively bonding a micropatch array to a substrate, the micropatch array having a plurality of micron-scale pillars, each of the micron-scale pillars in the plurality of micron-scale pillars containing a plurality of plasmonic nanoparticles dispersed within a polymer matrix; and in a subsequent step etching a portion of the polymer matrix to expose at least a portion of the plasmonic nanoparticles at or near a surface of the micron-scale pillars. Membranes and textiles containing the mechanically robust surface-enhanced Raman spectroscopy (SERS) substrates are also provided.