公开(公告)号：US20240142382A1

公开(公告)日：2024-05-02

申请号：US18280452

申请日：2022-03-04

Applicant: Virginia Tech Intellectual Properties, Inc.

Inventor： Wei ZHOU ,  Wonil NAM

IPC: G01N21/65 ,  G01N33/483

CPC classification number: G01N21/658 ,  G01N33/4833 ,  G01N2201/06113

Abstract: In one aspect, the disclosure relates to methods of label-free surface-enhanced Raman spectroscopy (SERS) comprising plasmonically enhanced electronic Raman scattering (ERS) signals from metal nanostructures as an internal calibration standard to improve multivariate analysis of living biological systems, and the uses of the methods therein. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

公开(公告)号：US20230168201A1

公开(公告)日：2023-06-01

申请号：US17587541

申请日：2022-01-28

Applicant: KOREA RESEARCH INSTITUTE OF STANDARDS AND SCIENCE ,  VIRGINIA TECH INTELLECTUAL PROPERTIES, INC.

Inventor： Eun-Ah YOU ,  Zhou WEI ,  Wonil NAM ,  Wansun KIM

IPC: G01N21/65 ,  G01N33/68

CPC classification number: G01N21/658 ,  G01N33/6896 ,  B82Y40/00

Abstract: The present disclosure relates to a surface-enhanced Raman spectroscopy complex probe capable of effectively detecting a catecholamine compound even at extremely low concentrations. The complex probe includes a nanolaminate including a nanogap and metal nanoparticles. In this case, the nanolaminate and the metal nanoparticles are modified to a compound that may be bound to each functional group included in catecholamine, and thus, catecholamine included in an analyte is doubly recognized by the complex probe. In addition, since a hotspot emitting a strong SERS signal is formed by a nanogap included in a nanolaminate, it is possible to effectively detect a catecholamine compound even at extremely low concentrations.