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公开(公告)号：US12048719B2
公开(公告)日：2024-07-30
申请号：US16983190
申请日：2020-08-03
CPC分类号： A61K35/50 , C12N5/00 , C12N5/0605
摘要： A biological composition has a mixture of mechanically selected allogeneic biologic material derived from placental tissue. The mixture has non-whole cellular components including vesicular components and active and inactive components of biological activity, cell fragments, cellular excretions, cellular derivatives, and extracellular components. The mixture including non-whole cell fractions including one or more of exosomes, transcriptosomes, proteasomes, membrane rafts, lipid rafts. The mixture is compatible with biologic function.
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公开(公告)号：US11925532B2
公开(公告)日：2024-03-12
申请号：US17547790
申请日：2021-12-10
发明人： Timothy Ganey , Shabnam Namin , Hanna Kaliada , Santiago Osorio
CPC分类号： A61F13/00034 , A61F13/00012 , A61F13/00017 , A61F13/00029 , A61F13/00995 , A61L15/40 , A61L27/3604 , B05D3/007 , C12N5/0605 , A61F2013/00314 , A61K2800/84 , C12N2533/92
摘要： A vented wound dressing barrier includes one or more membrane layers with a plurality of vents. The vents are cut along a perimeter of the vents through the one or more membrane layers. Each vent having a connection portion uncut relative to the one or more membrane layers thereby forming a hinge configured to allow the vents to open for drainage when exposed to fluid underlying the vented wound dressing barrier. The plurality of vents is each cut along the perimeter without removal of any of the membrane layer. The one or more membrane layers with the plurality of vents has a surface for covering a wound, the surface area in the absence of a fluid pressing on the vents having no openings or voids which reduce the surface area of a vented wound dressing barrier area covering a wound.
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公开(公告)号：US11406734B2
公开(公告)日：2022-08-09
申请号：US17071660
申请日：2020-10-15
摘要： A malleable demineralized bone composition consists of cortical bone made from a first portion and a second portion. The first portion and second portion of cortical bone is made from cut pieces freeze dried then ground into particles and demineralized then freeze-dried. A volume of the second portion is placed in a solution of sterile water to create a mixture, the water volume being seven times the volume of the second portion, the mixture is autoclaved under heat and pressure to form a gelatin, and the first portion is mixed with the gelatin to form a malleable putty or paste.
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公开(公告)号：US20220080081A1
公开(公告)日：2022-03-17
申请号：US17018472
申请日：2020-09-11
发明人： Timothy Ganey
摘要： A method of making infused non-demineralized cartilage fibers employs the following steps: cutting or shaving cartilage tissue into cartilage long aspect ratio fibers, washing the fibers, and infusing the fibers with a supernatant of biologic material or a polyampholyte cryoprotectant or a combination of both to create infused fibers.
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公开(公告)号：US11160904B2
公开(公告)日：2021-11-02
申请号：US15837694
申请日：2017-12-11
发明人： Timothy Ganey , Shabnam Namin , Renaud Sicard , Wendy W. Weston
摘要： A biological composition intermixed with a polyampholyte protectant for direct implantation has a mixture of biologic material and a volume of polyampholyte protectant. The mixture of biologic material has non-whole cellular components including vesicular components and active and inactive components of biological activity, cell fragments, cellular excretions, cellular derivatives, and extracellular components, or whole cells or combinations of the non-whole cellular components and whole cells, wherein the mixture is compatible with biologic function. The volume of polyampholyte protectant is intermixed with the mixture of biologic material, wherein the polyampholyte protectant is a liquid of a polyamine polymer compound of carboxylated poly-lysine and wherein the polyampholyte protectant forms a three-dimensional bonding shroud externally enveloping each of the non-whole cellular components, if any, and each of the whole cells, if any, of the mixture of biologic material.
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公开(公告)号：US11077148B2
公开(公告)日：2021-08-03
申请号：US15950365
申请日：2018-04-11
摘要： A biological composition has a mixture of mechanically selected allogeneic biologic material derived from placental tissue. The mixture has non-whole cellular components including vesicular components and active and inactive components of biological activity, cell fragments, cellular excretions, cellular derivatives, and extracellular components. The mixture including non-whole cell fractions including one or more of exosomes, transcriptosomes, proteasomes, membrane rafts, lipid rafts. The mixture is compatible with biologic function.
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公开(公告)号：US11077147B2
公开(公告)日：2021-08-03
申请号：US14810003
申请日：2015-07-27
摘要： A biological composition has a mixture of mechanically selected allogeneic biologic material derived from placental tissue. The mixture has non-whole cellular components including vesicular components and active and inactive components of biological activity, cell fragments, cellular excretions, cellular derivatives, and extracellular components. The mixture including non-whole cell fractions including one or more of exosomes, transcriptosomes, proteasomes, membrane rafts, lipid rafts. The mixture is compatible with biologic function.
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公开(公告)号：US20210178020A1
公开(公告)日：2021-06-17
申请号：US17114896
申请日：2020-12-08
摘要： A biologic composition responsive to inflammation has an allograft scaffold matrix for injection or implantation. The allograft scaffold matrix has donor quiescent and/or senescent cells. The donor quiescent and/or senescent cells react in response to signaling of inflammation from host cells or matrix. The reaction to signaling causes the donor quiescent and/or senescent cells to secrete anti-inflammatory cytokines and secrete exosomes to initiate regeneration of the area of the inflammation. The biologic composition further has a cryoprotectant. The cryoprotectant is a polyampholyte, preferably the polyampholyte is an ε-poly-L-lysine. The cryoprotectant is not DMSO or glycerol based. The cryoprotectant is suitable for direct implantation without washing from the allograft scaffold matrix in either a diluted or non-diluted state.
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公开(公告)号：US20210029987A1
公开(公告)日：2021-02-04
申请号：US17071599
申请日：2020-10-15
发明人： Harry Thomas Temple , Timothy Ganey , Stephanie Gonzalez , Tracy Scott Anderson , Shabnam Namin
摘要： A viable disc regenerative composition has a micronized material of nucleus pulposus and a biological composition made from a mixture of mechanically selected allogeneic biologic material derived from bone marrow having non-whole cellular components including vesicular components and active and inactive components of biological activity, cell fragments, cellular excretions, cellular derivatives, and extracellular components; and wherein the mixture is compatible with biologic function and further includes non-expanded whole cells. The biological composition is predisposed to demonstrate or support elaboration of active volume or spatial geometry consistent in morphology with that of disc tissue. The viable disc regenerative composition extends regenerative resonance that compliments or mimics disc tissue complexity.
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公开(公告)号：US20200230174A1
公开(公告)日：2020-07-23
申请号：US16710472
申请日：2019-12-11
发明人： Connie Chung , Shabnam Namin , Timothy Ganey , Renaud Sicard
摘要： Compositions of exosomes are provided that include a plurality of exosomes and a biocompatible cryoprotectant, such that the exosomes are suspended in the biocompatible cryoprotectant as a colloidal suspension of exosomes. Preferably, the cryoprotectant is a carboxylated E-poly-1-lysine (COOH-PLL) cryoprotectant, but other moieties might be extended to the claim of hybridization polymers to incorporate preferred embodiments for lineage and tissue specific intentions. The colloidal suspension of exosomes can be frozen at −65 degrees C. or colder and thereafter stored as a frozen composition of exosomes or can be freeze-dried and thereafter stored at ambient conditions in a vacuum sealed container. Also provided are kits comprising the composition of exosomes and methods of making the compositions of exosomes.
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