专利检索 ap:("Vladimir Muzykantov" OR "Abd Higazi" OR "Juan Murciano" OR "Douglas Cines" OR "Ronald Taylor") AND inv:"Juan Murciano" 第 1 页

1.

发明申请
Compositions and methods for prevention and treatment of uncontrolled formation of intravascular fibrin clots 有权
标题翻译：用于预防和治疗血管内纤维蛋白凝块不受控制形成的组合物和方法

公开(公告)号：US20080050389A1

公开(公告)日：2008-02-28

申请号：US11640737

申请日：2006-12-18

申请人： Vladimir Muzykantov , Abd Higazi , Juan Murciano , Douglas Cines , Ronald Taylor

发明人： Vladimir Muzykantov , Abd Higazi , Juan Murciano , Douglas Cines , Ronald Taylor

IPC分类号： A61K39/395 , A61K39/00 , A61P7/00

CPC分类号： A61K38/49 , A61K35/18 , A61K38/166 , A61K38/177 , A61K2300/00

摘要： Compositions and methods for prevention and treatment of uncontrolled formation of intravascular fibrin clots are provided wherein fibrinolytic or anticoagulant drugs are biocompatibly coupled to red blood cell carriers.

摘要翻译： 提供了用于预防和治疗血管内纤维蛋白凝块的不受控形成的组合物和方法，其中纤维蛋白溶解或抗凝血药物与红细胞载体生物相容性偶联。

2.

发明申请
Compositions and methods for selective dissolution of nascent intravascular blood clots 审中-公开

公开(公告)号：US20060140917A1

公开(公告)日：2006-06-29

申请号：US11352720

申请日：2006-02-13

申请人： Vladimir Muzykantov , Juan Murciano , Douglas Cines

发明人： Vladimir Muzykantov , Juan Murciano , Douglas Cines

IPC分类号： A61K35/14

CPC分类号： A61K9/0019 , A61K35/18 , A61K38/49

摘要： Compositions and methods for prevention and treatment of uncontrolled formation of intravascular fibrin clots, which are capable of selective dissolution of pathological nascent clots formed intravascularly, with minimal risk of unwanted dissolution of pre-existing hemostatic clots, are provided wherein fibrinolytic or anticoagulant drugs are biocompatibly coupled to red blood cell carriers.

3.

发明申请
Targeting and prolonging association of drugs to the luminal surface of the pulmonary vascular endothelial cells 有权
标题翻译：靶向和延长药物与肺血管内皮细胞的腔表面的关联

公开(公告)号：US20060024303A1

公开(公告)日：2006-02-02

申请号：US11234594

申请日：2005-09-23

申请人： Vladimir Muzykantov , Juan Murciano , D. Granger

发明人： Vladimir Muzykantov , Juan Murciano , D. Granger

IPC分类号： A61K39/395

CPC分类号： A61K47/6849

摘要： Methods for targeting and prolonging association of a selected drug to the luminal surface of pulmonary vascular endothelium of an animal are provided wherein a selected drug is administered to an animal in combination with a non-internalizable antibody which binds to an antigen on the luminal surface of the pulmonary vasculature. This method is particularly useful in dissolution of fibrin clots or prevention of the intravascular coagulation in the pulmonary vasculature.

摘要翻译： 提供了将所选择的药物与动物的肺血管内皮的腔表面的靶向和延长关联的方法，其中将选择的药物与非内在化抗体组合给予动物，所述非内在抗体结合至腔内表面上的抗原肺血管系统。该方法在溶解纤维蛋白凝块或预防肺血管中的血管内凝血时特别有用。