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1.发明申请公开(公告)号：US20060024303A1
公开(公告)日：2006-02-02
申请号：US11234594
申请日：2005-09-23
申请人： Vladimir Muzykantov , Juan Murciano , D. Granger
发明人： Vladimir Muzykantov , Juan Murciano , D. Granger
IPC分类号： A61K39/395
CPC分类号： A61K47/6849
摘要： Methods for targeting and prolonging association of a selected drug to the luminal surface of pulmonary vascular endothelium of an animal are provided wherein a selected drug is administered to an animal in combination with a non-internalizable antibody which binds to an antigen on the luminal surface of the pulmonary vasculature. This method is particularly useful in dissolution of fibrin clots or prevention of the intravascular coagulation in the pulmonary vasculature.
摘要翻译： 提供了将所选择的药物与动物的肺血管内皮的腔表面的靶向和延长关联的方法，其中将选择的药物与非内在化抗体组合给予动物，所述非内在抗体结合至腔内表面上的抗原 肺血管系统。 该方法在溶解纤维蛋白凝块或预防肺血管中的血管内凝血时特别有用。
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2.发明申请Compositions and methods for prevention and treatment of uncontrolled formation of intravascular fibrin clots 有权用于预防和治疗血管内纤维蛋白凝块不受控制形成的组合物和方法公开(公告)号：US20080050389A1
公开(公告)日：2008-02-28
申请号：US11640737
申请日：2006-12-18
申请人： Vladimir Muzykantov , Abd Higazi , Juan Murciano , Douglas Cines , Ronald Taylor
发明人： Vladimir Muzykantov , Abd Higazi , Juan Murciano , Douglas Cines , Ronald Taylor
IPC分类号： A61K39/395 , A61K39/00 , A61P7/00
CPC分类号： A61K38/49 , A61K35/18 , A61K38/166 , A61K38/177 , A61K2300/00
摘要： Compositions and methods for prevention and treatment of uncontrolled formation of intravascular fibrin clots are provided wherein fibrinolytic or anticoagulant drugs are biocompatibly coupled to red blood cell carriers.
摘要翻译： 提供了用于预防和治疗血管内纤维蛋白凝块的不受控形成的组合物和方法，其中纤维蛋白溶解或抗凝血药物与红细胞载体生物相容性偶联。
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3.发明申请公开(公告)号：US20060140917A1
公开(公告)日：2006-06-29
申请号：US11352720
申请日：2006-02-13
IPC分类号： A61K35/14
CPC分类号： A61K9/0019 , A61K35/18 , A61K38/49
摘要： Compositions and methods for prevention and treatment of uncontrolled formation of intravascular fibrin clots, which are capable of selective dissolution of pathological nascent clots formed intravascularly, with minimal risk of unwanted dissolution of pre-existing hemostatic clots, are provided wherein fibrinolytic or anticoagulant drugs are biocompatibly coupled to red blood cell carriers.
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公开(公告)号：US09028829B2
公开(公告)日：2015-05-12
申请号：US12653465
申请日：2009-12-15
IPC分类号： A61K39/44 , A61N2/10 , A61M31/00 , A61K9/50 , A61K9/51 , A61K47/42 , A61K47/48 , A61K48/00 , A61L31/16 , C12N15/11 , C12N15/86
CPC分类号： A61K9/5094 , A61K9/5115 , A61K9/5123 , A61K9/5146 , A61K9/5153 , A61K9/5169 , A61K9/5192 , A61K47/42 , A61K47/59 , A61K47/645 , A61K47/6455 , A61K47/6849 , A61K47/6921 , A61K47/6937 , A61K48/0008 , A61K48/0041 , A61K48/0083 , A61L31/16 , A61L2300/416 , A61L2300/60 , A61L2300/624 , C12N15/111 , C12N15/86 , C12N2320/32 , C12N2710/10343
摘要： Systems and methods for magnetic targeting of therapeutic particles are provided. Therapeutic particles comprise one or more magnetic or magnetizable materials and at least one therapeutic agent. Therapeutic particles are specifically targeted using uniform magnetic fields capable of magnetizing magnetizable materials, and can be targeted to particular locations in the body, or can be targeted for capture, containment, and removal. Therapeutic particles can comprise antioxidant enzymes, and can be targeted to cells to protect the cells from oxidative damage.
摘要翻译： 提供了用于治疗颗粒的磁性靶向的系统和方法。 治疗性颗粒包含一种或多种磁性或可磁化材料和至少一种治疗剂。 使用能够磁化可磁化材料的均匀磁场来特异性地靶向治疗颗粒，并且可以将其靶向到身体中的特定位置，或者可以被靶向用于捕获，容纳和移除。 治疗性颗粒可以包含抗氧化酶，并且可以靶向细胞以保护细胞免受氧化损伤。
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公开(公告)号：US20100260780A1
公开(公告)日：2010-10-14
申请号：US12653465
申请日：2009-12-15
CPC分类号： A61K9/5094 , A61K9/5115 , A61K9/5123 , A61K9/5146 , A61K9/5153 , A61K9/5169 , A61K9/5192 , A61K47/42 , A61K47/59 , A61K47/645 , A61K47/6455 , A61K47/6849 , A61K47/6921 , A61K47/6937 , A61K48/0008 , A61K48/0041 , A61K48/0083 , A61L31/16 , A61L2300/416 , A61L2300/60 , A61L2300/624 , C12N15/111 , C12N15/86 , C12N2320/32 , C12N2710/10343
摘要： Systems and methods for magnetic targeting of therapeutic particles are provided. Therapeutic particles comprise one or more magnetic or magnetizable materials and at least one therapeutic agent. Therapeutic particles are specifically targeted using uniform magnetic fields capable of magnetizing magnetizable materials, and can be targeted to particular locations in the body, or can be targeted for capture, containment, and removal. Therapeutic particles can comprise antioxidant enzymes, and can be targeted to cells to protect the cells from oxidative damage.
摘要翻译： 提供了用于治疗颗粒的磁性靶向的系统和方法。 治疗性颗粒包含一种或多种磁性或可磁化材料和至少一种治疗剂。 使用能够磁化可磁化材料的均匀磁场来特异性地靶向治疗颗粒，并且可以将其靶向到身体中的特定位置，或者可以被靶向用于捕获，容纳和移除。 治疗性颗粒可以包含抗氧化酶，并且可以靶向细胞以保护细胞免受氧化损伤。
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公开(公告)号：US20130156792A9
公开(公告)日：2013-06-20
申请号：US12653465
申请日：2009-12-15
CPC分类号： A61K9/5094 , A61K9/5115 , A61K9/5123 , A61K9/5146 , A61K9/5153 , A61K9/5169 , A61K9/5192 , A61K47/42 , A61K47/59 , A61K47/645 , A61K47/6455 , A61K47/6849 , A61K47/6921 , A61K47/6937 , A61K48/0008 , A61K48/0041 , A61K48/0083 , A61L31/16 , A61L2300/416 , A61L2300/60 , A61L2300/624 , C12N15/111 , C12N15/86 , C12N2320/32 , C12N2710/10343
摘要： Systems and methods for magnetic targeting of therapeutic particles are provided. Therapeutic particles comprise one or more magnetic or magnetizable materials and at least one therapeutic agent. Therapeutic particles are specifically targeted using uniform magnetic fields capable of magnetizing magnetizable materials, and can be targeted to particular locations in the body, or can be targeted for capture, containment, and removal. Therapeutic particles can comprise antioxidant enzymes, and can be targeted to cells to protect the cells from oxidative damage.
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公开(公告)号：US20070065451A1
公开(公告)日：2007-03-22
申请号：US11599831
申请日：2006-11-15
申请人： Vladimir Muzykantov , Steve Albelda
发明人： Vladimir Muzykantov , Steve Albelda
IPC分类号： A61K39/395 , C07K16/46 , C07K16/30
CPC分类号： C07K16/2803 , A61K47/6898 , B82Y5/00 , C07K2317/77
摘要： A method for enhancing intracellular delivery of effector molecules is provided. The method involves modifying selected antibodies with biotin and streptavidin, conjugating these antibodies with an effector molecule, and delivering the conjugated effector to an intracellular target specifically recognized by the antibody.
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公开(公告)号：US20060127386A1
公开(公告)日：2006-06-15
申请号：US11266785
申请日：2005-11-04
申请人： Vladimir Muzykantov , Tom Dziubla
发明人： Vladimir Muzykantov , Tom Dziubla
CPC分类号： A61K38/44 , A61K9/5031 , A61K9/5153 , A61K9/5192 , A61K38/48 , A61K47/34
摘要： The present invention is a method for encapsulating active protein in a polymeric nanocarrier. The instant method employs homogenization at subzero temperatures so that enzyme activity is retained. Enzymes which can be encapsulated by the present method include, for example, antioxidant enzymes and xenobiotic detoxifying enzymes. Encapsulation of an enzyme protects it from protease degradation and increases therapeutic half-life. Advantageously, polymeric nanoparticles of the invention are permeable to enzyme substrates and therefore enzymes encapsulated by the instant method can exert their effect without release from the nanocarrier. Methods for decomposing a reactive oxygen species, protecting against vascular oxidative stress, and detoxifying a xenobiotic are also provided.
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