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13 条记录 (耗时 0.029 秒)

    Thin printing paper and a process for manufacturing said paper
    4.
    发明授权
    Thin printing paper and a process for manufacturing said paper 失效
    薄印纸和制造所述纸的方法

    公开(公告)号：US5916420A

    公开(公告)日：1999-06-29

    申请号：US527357

    申请日：1995-09-12

    申请人： Hartmut Wurster ,  Hans-Peter Hofmann

    发明人： Hartmut Wurster ,  Hans-Peter Hofmann

    IPC分类号： D21H19/36 ,  D21H11/14 ,  D21H19/50 ,  D21H19/52 ,  D21H19/54 ,  D21H19/84 ,  D21H27/30 ,  D21H19/44 ,  D21H19/40

    CPC分类号： D21H11/14 ,  D21H19/50 ,  D21H19/52 ,  D21H19/54 ,  D21H19/84

    摘要： The present invention relates to a thin printing paper with a weight per unit area in the range below 49 g/m.sup.2 and which contains wood and which is provided with surface pigmentation and which incorporates a mixture of a swellable coating silicate (sodium bentonite) and, for the remainder, conventional coating pigments as the pigment and which, in addition, contains only bonding agent that is a natural organic bonding agent, essentially starch. Even if only lightly calendered, the paper is equally well suited for rotogravure printing and for rotary offset printing. It is preferred that the paper also contain a proportion of processed fibres obtained from old-paper.

    摘要翻译： 本发明涉及一种薄型印刷纸，每单位面积的重量在49g / m2以下的范围内，并且含有木材并且具有表面色素沉积，并且包含可膨胀的涂层硅酸盐（钠膨润土）和 对于其余的，常规涂料颜料作为颜料，并且另外仅含有作为天然有机粘合剂的粘合剂，基本上是淀粉。 即使只是轻轻压延，纸张同样适用于轮转凹版印刷和旋转胶版印刷。 优选的是，纸也含有一定比例的由旧纸获得的加工纤维。

    Pyrrolyl tetrahydroquinoxalin diones, their production and use in the treatment of diseases
    5.
    发明授权
    Pyrrolyl tetrahydroquinoxalin diones, their production and use in the treatment of diseases 失效
    吡咯基四氢喹喔啉二氢睾酮，其生产和用于治疗疾病

    公开(公告)号：US06407109B1

    公开(公告)日：2002-06-18

    申请号：US09000277

    申请日：1998-01-27

    申请人： Wilfried Lubisch ,  Berthold Behl ,  Hans-Peter Hofmann ,  Hans-Jürgen Teschendorf

    发明人： Wilfried Lubisch ,  Berthold Behl ,  Hans-Peter Hofmann ,  Hans-Jürgen Teschendorf

    IPC分类号： A61K31498

    CPC分类号： C07D401/14 ,  C07D403/04

    摘要： Pyrrolylquinoxalinediones of the formula I and their tautomeric and isomeric forms, and their physiologically tolerated salts, where the variables have the following meanings: R1 hydrogen, cyclohexyl an aliphatic radical which has 1 to 4 carbon atoms and can carry the radical —COOR5, where R5 is hydrogen or C1-C4-alkyl, R2 —COOH, —COO—C1-C4, —COO—(CH2)m—Ph, —CONR6R7 and where m can be an integer from 1 to 6, R6 can be hydrogen, C1-C4-alkyl or OH and R7 can be hydrogen, C1-C4-alkyl, where all the phenyl or pyridyl rings present in R2 can also be substituted by up to 3 of the following radicals: C1-C4-alkyl, halogen, —O—C1-C4-alkyl, —OCF3, —NO2, —CN, —COOR5 or —CONHR5, R3 —CF3, —NO2, —CN, and R4 hydrogen or R3 and R4 can together be a fused-on benzene ring. The compounds are suitable as drugs for human and veterinary medicine.

    摘要翻译： 具有式I的吡咯基喹喔啉及其互变异构体和异构体形式及其生理学耐受盐，其中变量具有以下含义：具有1至4个碳原子并且可以携带-COOR5基团的R1氢，环己烷基脂族基团，其中R5是氢或 C 1 -C 4烷基，R 2，其中m可以是1至6的整数，R 6可以是氢，C 1 -C 4 - 烷基或OH，且R 7可以是氢，C 1 -C 4 - 烷基，其中所有苯基或吡啶环存在于 R2还可以被多达3个以下基团取代：R3R4氢或R3和R4可以一起是稠合的苯环。 该化合物适合作为人兽药用药物。

    Use of 5-ht5-ligands in the treatment of neurodegenerative and neuropsychiatric disturbances
    9.
    发明授权
    Use of 5-ht5-ligands in the treatment of neurodegenerative and neuropsychiatric disturbances 失效
    5-ht5配体在治疗神经变性和神经精神障碍中的应用

    公开(公告)号：US06750221B1

    公开(公告)日：2004-06-15

    申请号：US09889157

    申请日：2001-07-11

    申请人： Francisco Javier Garcia-Ladona ,  Laszlo Szabo ,  Gerd Steiner ,  Hans-Peter Hofmann

    发明人： Francisco Javier Garcia-Ladona ,  Laszlo Szabo ,  Gerd Steiner ,  Hans-Peter Hofmann

    IPC分类号： A61K31505

    CPC分类号： G01N33/566 ,  A61K31/519 ,  G01N2500/02 ,  G01N2500/04

    摘要： The invention relates to the use of binding partners for 5-HT5-receptors in the treatment of neuropathological and in particular neurodegenerative and/or neuropsychiatric disturbances which can occur notably in cases of cerebral ishcemia, cerebral stroke, epilepsy and attacks in general, chronic schizophrenia, other psychotic illnesses, dementia, notably Alzheimer's disease, demyelination diseases, notably multiple sclerosis and brain tumors. The invention also relates to methods, especially screening methods, for identifying and characterizing such binding partners.

    摘要翻译： 本发明涉及5-HT5受体的结合配偶体在治疗神经病理学，特别是神经变性和/或神经精神障碍中的用途，其可以在脑血症，脑卒中，癫痫和一般发作的慢性精神分裂症 ，其他精神病，痴呆，特别是阿尔茨海默病，脱髓鞘疾病，特别是多发性硬化和脑肿瘤。 本发明还涉及用于鉴定和表征这些结合配偶体的方法，特别是筛选方法。

    Pyrrolyl quinoxalindiones their production and use as AMPA receptor antagonists
    10.
    发明授权
    Pyrrolyl quinoxalindiones their production and use as AMPA receptor antagonists 失效
    吡咯基喹喔啉对其生产和用作AMPA受体拮抗剂

    公开(公告)号：US06277850B1

    公开(公告)日：2001-08-21

    申请号：US09202153

    申请日：1998-12-09

    申请人： Wilfried Lubisch ,  Berthold Behl ,  Hans-Peter Hofmann ,  Laszlo Szabo

    发明人： Wilfried Lubisch ,  Berthold Behl ,  Hans-Peter Hofmann ,  Laszlo Szabo

    IPC分类号： A61K31498

    CPC分类号： C07D403/04

    摘要： Pyrrolylquinoxalinediones of the formula I and their tautomeric and isomeric forms, and their physiologically tolerated salts are described, where the variables have the following meaning: R1 hydrogen, C1-C6-alkyl, substituted by hydroxyl or carboxyl, R2 hydrogen, C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, a chlorine, fluorine or bromine atom, a trihalomethyl, cyano or nitro group or SO2—C1-C4-alkyl, R3 COOH or a radical which can be hydrolyzed to the carboxyl group, n 1 or 2.

    摘要翻译： 描述了式I的吡咯基喹喔啉以及它们的互变异构体和异构体形式及其生理上耐受的盐，其中变量具有以下含义：R 1氢，被羟基或羧基取代的C 1 -C 6 - 烷基，R 2氢，C 1 -C 6 - 烷基 ，C 2 -C 6 - 烯基，C 2 -C 6 - 炔基，氯，氟或溴原子，三卤甲基，氰基或硝基或SO 2 -C 1 -C 4 - 烷基，R 3 COOH或可被水解成羧基的基团 ，n 1或2。