公开(公告)号：US11305038B2

公开(公告)日：2022-04-19

申请号：US15747352

申请日：2016-07-21

Applicant: WAKE FOREST UNIVERSITY HEALTH SCIENCES

Inventor： James Yoo ,  In Kap Ko ,  Jennifer Huling ,  Anthony Atala

IPC: A61L27/56 ,  A61K35/44 ,  A61L27/24 ,  A61L27/38 ,  A61L27/50 ,  A61L27/52 ,  A61K35/33 ,  A61K35/34 ,  A61K35/39 ,  A61K35/407 ,  A61L27/20

Abstract: The present application relates to biomimetic three-dimensional (3D) scaffolds, constructs and methods of making the same. The three-dimensional scaffold can include a sacrificial internal cast and a durable external scaffold material, wherein the durable external scaffold material comprises a biocompatible material which completely surrounds the sacrificial internal cast and wherein the sacrificial internal cast be removed to yield a branching 3D network of hollow, vessel-like tubes that substantially mimics a native tissue or organ.