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公开(公告)号：US11931428B2
公开(公告)日：2024-03-19
申请号：US16947869
申请日：2020-08-21
Applicant: Wake Forest University Health Sciences
Inventor： John C. Lukesh, III
CPC classification number: A61K49/0039 , A61K9/0019 , A61K9/0053 , C07F11/00
Abstract: Provided herein is a compound of formula I:
and the use thereof for detecting the presence of hydrogen sulfide in cells or tissues in vitro or in vivo. The detecting may be useful, for example, in diagnosing cancer or other diseases related to imbalanced hydrogen sulfide (H2S) production such as neurodegenerative diseases.-
公开(公告)号：US20230227477A1
公开(公告)日：2023-07-20
申请号：US18002535
申请日：2021-06-24
Applicant: WAKE FOREST UNIVERSITY HEALTH SCIENCES
Inventor： John C. Lukesh, III , Katherine Virginia Ambrose
IPC: C07F5/02
CPC classification number: C07F5/02
Abstract: Provided herein according to some embodiments of the invention are aryl boronate and/or aryl diaminoboryl compounds. Also provided are methods of detecting the presence of hydrogen peroxide (H2O2) and/or other reactive oxygen species (ROS) in a cell and/or tissue by contacting the cell and/or tissue with aryl boronate and/or aryl diaminoboryl compounds. Also provided according to embodiments of the invention are methods of producing persulfides in the presence of hydrogen peroxide (H2O2) and/or other reactive oxygen species (ROS) in a cell and/or tissue by contacting the cell and/or tissue with aryl boronate and/or aryl diaminoboryl compounds.
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公开(公告)号：US20210052746A1
公开(公告)日：2021-02-25
申请号：US16947869
申请日：2020-08-21
Applicant: Wake Forest University Health Sciences
Inventor： John C. Lukesh, III
Abstract: Provided herein is a compound of formula I: and the use thereof for detecting the presence of hydrogen sulfide in cells or tissues in vitro or in vivo. The detecting may be useful, for example, in diagnosing cancer or other diseases related to imbalanced hydrogen sulfide (H2S) production such as neurodegenerative diseases.
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