公开(公告)号：US11708411B2

公开(公告)日：2023-07-25

申请号：US15106071

申请日：2014-12-22

Applicant: Wake Forest University Health Sciences

Inventor： Karen Haas ,  Jerome Mckay

IPC: A61K39/00 ,  A61K39/116 ,  A61K39/09 ,  A61K39/395 ,  C07K16/28

CPC classification number: C07K16/2827 ,  A61K39/092 ,  A61K39/116 ,  A61K39/3955 ,  A61K2039/505 ,  A61K2039/6087 ,  A61K2039/70 ,  C07K2317/76

Abstract: The presently disclosed subject matter provides therapeutic methods and compositions for the treatment of bacterial infections caused by Streptococcus pneumoniae. In particular, methods are provided for increasing protective antibody levels induced by pneumococcal polysaccharide vaccines in a subject in need thereof comprising administering to the subject an effective amount of an agent that inhibits the interaction between a PD-1 ligand and a PD-1 polypeptide. Immunogenic compositions are also provided comprising one or more pneumococcal polysaccharide antigens and an agent that inhibits the interaction between a PD-1 ligand and a PD-1 polypeptide.

公开(公告)号：US20160311904A1

公开(公告)日：2016-10-27

申请号：US15106071

申请日：2014-12-22

Applicant: WAKE FOREST UNIVERSITY HEALTH SCIENCES

Inventor： Karen Haas ,  Jerome Mckay

IPC: C07K16/28 ,  A61K39/395 ,  A61K39/09

CPC classification number: C07K16/2827 ,  A61K39/092 ,  A61K39/39 ,  A61K39/3955 ,  C07K2317/76

Abstract: The presently disclosed subject matter provides therapeutic methods and compositions for the treatment of bacterial infections caused by Streptococcus pneumoniae. In particular, methods are provided for increasing protective antibody levels induced by pneumococcal polysaccharide vaccines in a subject in need thereof comprising administering to the subject an effective amount of an agent that inhibits the interaction between a PD-1 ligand and a PD-1 polypeptide. Immunogenic compositions are also provided comprising one or more pneumococcal polysaccharide antigens and an agent that inhibits the interaction between a PD-1 ligand and a PD-1 polypeptide.

Abstract translation: 目前公开的主题提供用于治疗由肺炎链球菌引起的细菌感染的治疗方法和组合物。 特别地，提供了用于增加在有需要的受试者中由肺炎球菌多糖疫苗诱导的保护性抗体水平的方法，其包括向受试者施用有效量的抑制PD-1配体和PD-1多肽之间相互作用的药剂。 还提供了包含一种或多种肺炎球菌多糖抗原和抑制PD-1配体和PD-1多肽之间的相互作用的试剂的免疫原性组合物。