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公开(公告)号：US10130596B2
公开(公告)日：2018-11-20
申请号：US15637996
申请日：2017-06-29
发明人： David A. Dill
IPC分类号： A61K31/167 , A61K31/7088 , A61K31/33 , A61K31/192 , A61K31/437 , A61K31/27 , A61K45/06 , A61K31/616 , A61K31/44 , A61K31/122 , A61K31/405
摘要： Pharmaceutical compositions for reducing frequency of urination are disclosed. The pharmaceutical compositions comprise one or more prostaglandin pathway inhibitors and a pharmaceutically acceptable carrier. Also disclosed are methods of making and using the pharmaceutical compositions.
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2.发明授权Extended-release formulation for reducing the frequency of urination and method of use thereof 有权用于减少排尿频率的延长释放制剂及其使用方法公开(公告)号：US08685453B2
公开(公告)日：2014-04-01
申请号：US13847927
申请日：2013-03-20
发明人： David A. Dill
IPC分类号： A61K31/167 , A61K31/616 , A61K31/192 , A61K31/216 , A61K31/4725 , A61K31/4025 , A61K31/46 , A61K31/405 , A61K31/12 , A61K45/06
CPC分类号： A61K31/60 , A61K9/0002 , A61K31/12 , A61K31/167 , A61K31/19 , A61K31/192 , A61K31/216 , A61K31/4025 , A61K31/405 , A61K31/46 , A61K31/4725 , A61K31/616 , A61K45/06 , A61K2300/00
摘要： Methods and compositions for reducing the frequency of urination are disclosed. One method comprises administering to a subject in need thereof an effective amount of a pharmaceutical composition comprising an analgesic agent formulated in an extended-release formulation. Another method comprises administering to a subject in need thereof an effective amount of a pharmaceutical composition comprising multiple active ingredients formulated for extended-release. Yet another method comprises administering to a subject in need thereof an effective amount of a diuretic followed with another administration of a pharmaceutical composition comprising an analgesic agent formulated for extended-release.
摘要翻译： 公开了减少排尿频率的方法和组合物。 一种方法包括向有需要的受试者施用有效量的药物组合物，其包含配制在延长释放制剂中的止痛剂。 另一种方法包括向有需要的受试者施用有效量的药物组合物，其包含配制用于延长释放的多种活性成分。 另一种方法包括向有需要的受试者施用有效量的利尿剂，随后另外施用包含配制用于延长释放的止痛剂的药物组合物。
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3.发明授权公开(公告)号：US10792261B2
公开(公告)日：2020-10-06
申请号：US16131443
申请日：2018-09-14
发明人： David A. Dill
IPC分类号： A61K31/192 , A61K9/20 , A61K9/28 , A61K31/46 , A61K31/4025 , A61K31/4725 , A61K31/216 , A61K31/616 , A61K45/06 , A61K31/167 , A61K31/60 , A61K31/405 , A61K31/19 , A61K31/12
摘要： Compositions for reducing the frequency of urination and methods of manufacturing the compositions are disclosed. The compositions comprises a first component having an immediate-release subcomponent and an extended-release subcomponent, wherein the first component is formulated to release the subcomponents immediately after administration; and a second component comprising an immediate-release subcomponent and an extended-release subcomponent, wherein the second component is formulated for a delayed-release of the subcomponents.
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公开(公告)号：US10105328B2
公开(公告)日：2018-10-23
申请号：US14975332
申请日：2015-12-18
发明人： David A. Dill
IPC分类号： A61K31/167 , A61K45/06 , A61K31/7088 , A61K31/44 , A61K39/395 , A61K31/192 , A61K31/27 , A61K31/437 , A61K31/616 , A61K31/122 , A61K31/405
摘要： Pharmaceutical compositions for reducing frequency of urination are disclosed. The pharmaceutical compositions comprise one or more prostaglandin pathway inhibitors and a pharmaceutically acceptable carrier. Also disclosed are methods of making and using the pharmaceutical compositions.
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5.发明授权公开(公告)号：US09789124B2
公开(公告)日：2017-10-17
申请号：US14815416
申请日：2015-07-31
发明人： David A. Dill , Ilya A. Volfson
IPC分类号： A61K31/616 , A61K31/192 , A61K31/56 , A61K31/18 , A61K31/167 , A61K45/06 , A61K31/164 , A61K31/473 , A61K9/28 , A61K31/122 , A61K31/216 , A61K31/4025 , A61K31/405 , A61K31/46 , A61K31/4725
CPC分类号： A61K31/616 , A61K9/284 , A61K9/2846 , A61K9/2866 , A61K31/122 , A61K31/164 , A61K31/167 , A61K31/18 , A61K31/192 , A61K31/216 , A61K31/4025 , A61K31/405 , A61K31/46 , A61K31/4725 , A61K31/473 , A61K31/56 , A61K45/06 , A61K2300/00
摘要： A method for reducing the frequency of urination is disclosed. The method comprises administering to a subject in need thereof an effective amount of a pharmaceutical composition comprising one or more analgesic agents and one or more α-blockers. In one embodiment, the one or more analgesic agents are formulated for extended-release.
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6.发明授权Pharmaceutical formulation for reducing frequency of urination and method of use thereof 有权用于减少排尿频率的药物制剂及其使用方法公开(公告)号：US09415048B2
公开(公告)日：2016-08-16
申请号：US13930765
申请日：2013-06-28
发明人： David A. Dill
IPC分类号： A61K31/4985 , A61K31/192 , A61K31/437 , A61K31/216 , A61K31/405 , A61K31/12 , A61K31/167 , A61K45/06 , A61K9/28 , A61K31/122 , A61K31/616 , A61K9/00 , A61K9/08
CPC分类号： A61K31/4985 , A61K9/0019 , A61K9/08 , A61K9/284 , A61K9/2846 , A61K9/2866 , A61K31/12 , A61K31/122 , A61K31/167 , A61K31/192 , A61K31/216 , A61K31/405 , A61K31/437 , A61K31/616 , A61K45/06 , A61K2300/00
摘要： Methods and compositions for reducing frequency of urination are disclosed. One method comprises administering to a subject in need thereof an effective amount of a pharmaceutical composition comprising one or more analgesic agents.
摘要翻译： 公开了减少排尿频率的方法和组合物。 一种方法包括向有需要的受试者施用有效量的包含一种或多种止痛剂的药物组合物。
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7.发明授权Delayed-release formulation for reducing the frequency of urination and method of use thereof 有权用于减少排尿频率的延迟释放制剂及其使用方法公开(公告)号：US08703184B2
公开(公告)日：2014-04-22
申请号：US13847940
申请日：2013-03-20
发明人： David A. Dill
IPC分类号： A61K31/616 , A61K31/167 , A61K31/216 , A61K31/4709 , A61K31/4025 , A61K31/439 , A61K31/192
CPC分类号： A61K31/618 , A61K9/0004 , A61K9/2846 , A61K9/2866 , A61K9/288 , A61K9/4891 , A61K31/167 , A61K31/19 , A61K31/192 , A61K31/216 , A61K31/4025 , A61K31/439 , A61K31/4709 , A61K31/60 , A61K31/616 , A61K45/06 , A61K2300/00
摘要： Methods and compositions for reducing the frequency of urination are disclosed. One method comprises administering to a subject in need thereof an effective amount of a pharmaceutical composition comprising an analgesic agent formulated in a delayed-release formulation. Another method comprises administering to a subject in need thereof an effective amount of a pharmaceutical composition comprising multiple active ingredients. Yet another method comprises administering to a subject in need thereof an effective amount of a diuretic followed with another administration of a pharmaceutical composition comprising an analgesic agent.
摘要翻译： 公开了减少排尿频率的方法和组合物。 一种方法包括向有需要的受试者施用有效量的药物组合物，其包含配制在延迟释放制剂中的止痛剂。 另一种方法包括向有需要的受试者施用有效量的包含多种活性成分的药物组合物。 另一种方法包括向有需要的受试者施用有效量的利尿剂，随后另外施用包含止痛剂的药物组合物。
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8.发明申请公开(公告)号：US20130224291A1
公开(公告)日：2013-08-29
申请号：US13847940
申请日：2013-03-20
发明人： David A. Dill
IPC分类号： A61K31/616 , A61K31/216 , A61K31/192 , A61K31/4025 , A61K31/439 , A61K31/167 , A61K31/4709
CPC分类号： A61K31/618 , A61K9/0004 , A61K9/2846 , A61K9/2866 , A61K9/288 , A61K9/4891 , A61K31/167 , A61K31/19 , A61K31/192 , A61K31/216 , A61K31/4025 , A61K31/439 , A61K31/4709 , A61K31/60 , A61K31/616 , A61K45/06 , A61K2300/00
摘要： Methods and compositions for reducing the frequency of urination are disclosed. One method comprises administering to a subject in need thereof an effective amount of a pharmaceutical composition comprising an analgesic agent formulated in a delayed-release formulation. Another method comprises administering to a subject in need thereof an effective amount of a pharmaceutical composition comprising multiple active ingredients. Yet another method comprises administering to a subject in need thereof an effective amount of a diuretic followed with another administration of an pharmaceutical composition comprising an analgesic agent.
摘要翻译： 公开了减少排尿频率的方法和组合物。 一种方法包括向有需要的受试者施用有效量的药物组合物，其包含配制在延迟释放制剂中的止痛剂。 另一种方法包括向有需要的受试者施用有效量的包含多种活性成分的药物组合物。 另一种方法包括向有需要的受试者施用有效量的利尿剂，随后另外施用包含止痛剂的药物组合物。
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公开(公告)号：US20180344802A1
公开(公告)日：2018-12-06
申请号：US16057330
申请日：2018-08-07
发明人： David A. Dill
IPC分类号： A61K38/11 , A61K45/06 , A61K31/616 , A61K31/167 , A61K38/12 , A61K9/50 , A61K9/28 , A61K38/48 , A61K31/122 , A61K31/192 , A61K31/405 , A61K31/4985
CPC分类号： A61K38/095 , A61K9/20 , A61K9/284 , A61K9/2846 , A61K9/2866 , A61K9/2886 , A61K9/5073 , A61K9/5078 , A61K31/122 , A61K31/167 , A61K31/192 , A61K31/405 , A61K31/4985 , A61K31/616 , A61K38/12 , A61K38/4893 , A61K45/06 , A61P13/10
摘要： Methods and compositions for treating bedwetting are disclosed. One method comprises administering to a subject in need thereof an effective amount of a pharmaceutical composition comprising one or more analgesic agents.
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公开(公告)号：US20180344673A1
公开(公告)日：2018-12-06
申请号：US16057261
申请日：2018-08-07
发明人： David A. Dill
IPC分类号： A61K31/167 , A61K31/437 , A61K45/06 , A61K31/616 , A61K31/192
CPC分类号： A61K31/167 , A61K31/192 , A61K31/437 , A61K31/616 , A61K45/06 , A61K2300/00
摘要： Methods and compositions for reducing bladder spasms are disclosed. The methods comprise administering to a subject in need thereof a pharmaceutical composition comprising an effective amount of acetaminophen and an effective amount of at least one non-steroidal anti-inflammatory agent (NSAID). In another embodiment, a method for reducing bladder spasms comprising administering to a subject in need thereof a pharmaceutical composition comprising an effective amount of at least one prostaglandin (PG) pathway inhibitor, wherein the at least one PG pathway inhibitor is not acetaminophen or an NSAID.
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