公开(公告)号：US20100286248A1

公开(公告)日：2010-11-11

申请号：US12566951

申请日：2009-09-25

申请人： WU-BO LI ,  MICHAEL KINCH ,  MICHAEL GOLDBLATT

发明人： WU-BO LI ,  MICHAEL KINCH ,  MICHAEL GOLDBLATT

IPC分类号： A61K31/7088 ,  C07H21/00 ,  C07K14/00 ,  C12N5/079 ,  G01N33/53 ,  A61P25/28

CPC分类号： G01N33/6896 ,  C07K14/4711 ,  G01N2800/2821

摘要： A human gene, fg01, on chromosome 8, is identified. This gene, and its expression product, human fg01, shares a homology under 70% with the corresponding murine gene, which has been linked to presentation of the Alzheimer's phenotype of Aβ plaques and hyperphosphorylated tau tangles. Upregulation appears to suppress the Alzheimer's phenotype, which may be effective in preventing the onset of symptoms or progression of symptoms associated with AD. Screening methods are also set forth.

摘要翻译： 鉴定出染色体8上的人类基因fg01。 该基因及其表达产物人fg01与相应的鼠基因具有70％以下的同源性，其与A＆bgr的阿尔茨海默氏症表现呈现相关; 斑块和超磷酸化tau缠结。 上调似乎可以抑制阿尔茨海默病的表型，这可能有效预防与AD有关的症状或进展症状。 还阐述了筛选方法。