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公开(公告)号:US20060116394A1
公开(公告)日:2006-06-01
申请号:US11284660
申请日:2005-11-22
申请人: Walter Burgess , Dalia Jakas , William Huffman , William Miller , Kenneth Newlander , Mark Seefeld , Irene Uzinskas
发明人: Walter Burgess , Dalia Jakas , William Huffman , William Miller , Kenneth Newlander , Mark Seefeld , Irene Uzinskas
IPC分类号: A61K31/4745 , A61K31/4439 , A61K31/4433 , C07D471/02 , C07D405/02 , C07D403/02
CPC分类号: C07D213/73 , A61K31/16 , A61K31/381 , A61K31/416 , A61K31/47 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D471/04 , C07D487/04 , C07D491/04
摘要: Compounds are disclosed which are Fab I inhibitors and are useful in the treatment bacterial infections.
摘要翻译: 公开了作为Fab I抑制剂并且可用于治疗细菌感染的化合物。
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公开(公告)号:US20050250810A1
公开(公告)日:2005-11-10
申请号:US11007927
申请日:2004-12-09
申请人: William Miller , Kenneth Newlander , Mark Seefeld , Irene Uzinskas , Walter DeWolf , Dalia Jakas
发明人: William Miller , Kenneth Newlander , Mark Seefeld , Irene Uzinskas , Walter DeWolf , Dalia Jakas
IPC分类号: G01N33/50 , A61K31/381 , A61K31/4045 , A61K31/407 , A61K31/44 , A61K31/443 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/47 , A61K31/4709 , A61K31/495 , A61K31/506 , A61K31/519 , A61K31/5365 , A61K31/5383 , A61P31/04 , A61P43/00 , C07D209/14 , C07D209/52 , C07D213/73 , C07D213/75 , C07D239/42 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/12 , C07D471/04 , C07D487/04 , C07D495/04 , C07D498/04 , G01N33/15 , C07D495/02 , C07D215/38 , A61K31/405 , A61K31/416 , A61K31/16
CPC分类号: C07D213/75 , A61K31/381 , A61K31/4436 , A61K31/4439 , A61K31/47 , A61K31/495 , A61K31/506 , A61K31/5365 , C07D209/14 , C07D209/52 , C07D239/42 , C07D401/12 , C07D405/12 , C07D471/04 , C07D487/04 , C07D495/04 , Y02A50/473
摘要: Compounds of the formula (I) are disclosed which are Fab I inhibitors and are useful in the treatment of bacterial infections.
摘要翻译: 公开了式(I)的化合物,其是Fab I抑制剂并且可用于治疗细菌感染。
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公开(公告)号:US08637509B2
公开(公告)日:2014-01-28
申请号:US13696601
申请日:2011-05-05
申请人: Joelle Lorraine Burgess , Neil Johnson , Steven D. Knight , Louis LaFrance , William H. Miller , Kenneth Newlander , Stuart Romeril , Meagan B. Rouse , Xinrong Tian , Sharad Kumar Verma , Dominic Suarez
发明人: Joelle Lorraine Burgess , Neil Johnson , Steven D. Knight , Louis LaFrance , William H. Miller , Kenneth Newlander , Stuart Romeril , Meagan B. Rouse , Xinrong Tian , Sharad Kumar Verma , Dominic Suarez
IPC分类号: A61K31/444 , A61P35/00 , A61K31/506 , A61K31/5377 , A61K31/513 , C07D471/04 , A61K31/4545
CPC分类号: C07D471/04 , C07D519/00
摘要: Herein are disclosed azaindazoles of formula (I) where the various groups are defined herein, and which are useful for treating cancer.
摘要翻译: 本文公开了式(I)的氮杂吲唑,其中各种基团在本文中定义,并且其可用于治疗癌症。
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公开(公告)号:US20060020008A1
公开(公告)日:2006-01-26
申请号:US11154989
申请日:2005-06-15
申请人: Andrew McDonald , Gustave Bergnes , Bainian Feng , David Morgans , Steven Knight , Kenneth Newlander , Dashyant Dhanak , Christopher Brook
发明人: Andrew McDonald , Gustave Bergnes , Bainian Feng , David Morgans , Steven Knight , Kenneth Newlander , Dashyant Dhanak , Christopher Brook
IPC分类号: A61K31/4178 , C07D405/02
CPC分类号: C07D405/06 , C07D311/22 , C07D311/36 , C07D405/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要: Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed.
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公开(公告)号:US20130059849A1
公开(公告)日:2013-03-07
申请号:US13696601
申请日:2011-05-05
申请人: Joelle Lorraine Burgess , Neil Johnson , Steven D. Knight , Louis Lafrance , William H. Miller , Kenneth Newlander , Stuart Romeril , Meagan B. Rouse , Xinrong Tian , Sharad Kumar Verma , Dominic Suarez
发明人: Joelle Lorraine Burgess , Neil Johnson , Steven D. Knight , Louis Lafrance , William H. Miller , Kenneth Newlander , Stuart Romeril , Meagan B. Rouse , Xinrong Tian , Sharad Kumar Verma , Dominic Suarez
IPC分类号: A61K31/444 , A61P35/00 , A61K31/506 , A61K31/5377 , A61K31/496 , A61K31/513 , C07D471/04 , A61K31/4545
CPC分类号: C07D471/04 , C07D519/00
摘要: Herein are disclosed azaindazoles of formula (I) where the various groups are defined herein, and which are useful for treating cancer.
摘要翻译: 本文公开了式(I)的氮杂吲唑,其中各种基团在本文中定义,并且其可用于治疗癌症。
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公开(公告)号:US20130053383A1
公开(公告)日:2013-02-28
申请号:US13696436
申请日:2011-05-05
申请人: Celine Duquenne , Neil Johnson , Steven D. Knight , Louis Lafrance , William H. Miller , Kenneth Newlander , Stuart Romeril , Meagan B. Rouse , Xinrong Tian , Sharad Kumar Verma
发明人: Celine Duquenne , Neil Johnson , Steven D. Knight , Louis Lafrance , William H. Miller , Kenneth Newlander , Stuart Romeril , Meagan B. Rouse , Xinrong Tian , Sharad Kumar Verma
IPC分类号: A61K31/4439 , A61P35/00 , A61P35/02 , C07D401/14 , A61K31/4545 , A61K31/496 , A61K31/506 , C07D413/14 , A61K31/5377 , C07D409/14 , C07D401/12 , A61K31/444
CPC分类号: C07D409/14 , C07D401/12 , C07D401/14 , C07D471/04
摘要: Herein are disclosed indazoles of formula (I) where the various groups are defined herein, and which are useful for treating cancer.
摘要翻译: 本文公开了式(I)的吲唑,其中各种基团在本文中定义,并且其可用于治疗癌症。
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公开(公告)号:US20080004308A1
公开(公告)日:2008-01-03
申请号:US11835434
申请日:2007-08-08
申请人: Dashyant Dhanak , Kenneth Newlander
发明人: Dashyant Dhanak , Kenneth Newlander
IPC分类号: A61K31/4745 , A61P35/00 , C07D471/02
CPC分类号: C07D471/04
摘要: The present invention relates to a compound represented by Formula (I): and pharmaceutically acceptable salts. Compounds of the present invention inhibit Aurora kinase, making them especially suitable for the treatment of a number of diseases, including solid tumor cancers and hematological cancers.
摘要翻译: 本发明涉及由式(I)表示的化合物及其药学上可接受的盐。 本发明的化合物抑制Aurora激酶,使其特别适用于治疗许多疾病,包括实体瘤癌症和血液癌症。
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公开(公告)号:US20070149561A1
公开(公告)日:2007-06-28
申请号:US11612531
申请日:2006-12-19
申请人: Dashyant DHANAK , Kenneth Newlander
发明人: Dashyant DHANAK , Kenneth Newlander
IPC分类号: A61K31/4745 , C07D471/02
CPC分类号: C07D471/04
摘要: The present invention relates to a compound represented by Formula (I): and pharmaceutically acceptable salts. Compounds of the present invention inhibit Aurora kinase, making them especially suitable for the treatment of a number of diseases, including solid tumor cancers and hematological cancers.
摘要翻译: 本发明涉及由式(I)表示的化合物及其药学上可接受的盐。 本发明的化合物抑制Aurora激酶,使其特别适用于治疗许多疾病,包括实体瘤癌症和血液癌症。
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公开(公告)号:US08846935B2
公开(公告)日:2014-09-30
申请号:US13696436
申请日:2011-05-05
申请人: Celine Duquenne , Neil Johnson , Steven D. Knight , Louis Lafrance , William H. Miller , Kenneth Newlander , Stuart Romeril , Meagan B. Rouse , Xinrong Tian , Sharad Kumar Verma
发明人: Celine Duquenne , Neil Johnson , Steven D. Knight , Louis Lafrance , William H. Miller , Kenneth Newlander , Stuart Romeril , Meagan B. Rouse , Xinrong Tian , Sharad Kumar Verma
IPC分类号: C07D401/00 , C07D405/00 , C07D231/56
CPC分类号: C07D409/14 , C07D401/12 , C07D401/14 , C07D471/04
摘要: Herein are disclosed indazoles of formula (I) where the various groups are defined herein, and which are useful for treating cancer.
摘要翻译: 本文公开了式(I)的吲唑,其中各种基团在本文中定义,并且其可用于治疗癌症。
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公开(公告)号:US20070219192A1
公开(公告)日:2007-09-20
申请号:US11592737
申请日:2006-11-02
IPC分类号: A61K31/5383 , A61K31/426 , A61K31/4745 , A61K31/4172 , A61K31/4184
CPC分类号: C07D233/61 , A61K31/4172 , A61K31/4184 , A61K31/426 , A61K31/4745 , A61K31/5383 , C07C217/70 , C07C235/34 , C07C237/22 , C07C275/24 , C07C307/06 , C07D233/14 , C07D233/64
摘要: Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of one or more mitotic kinesins are disclosed.
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