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公开(公告)号：US3991183A
公开(公告)日：1976-11-09
申请号：US573546
申请日：1975-05-01
申请人： Walter D. Celmer , Walter P. Cullen , Charles E. Moppett , John R. Oscarson , John B. Routien , Riichiro Shibakawa , Junsuke Tone
发明人： Walter D. Celmer , Walter P. Cullen , Charles E. Moppett , John R. Oscarson , John B. Routien , Riichiro Shibakawa , Junsuke Tone
摘要： Antibiotic Compound 37,504 is produced by the submerged aerobic fermentation under controlled conditions of a new species of Micromonospora designated Micromonospora viridifaciens sp. nov. Routien, ATCC 31146.
摘要翻译： 抗生素化合物37,504通过在受控条件下的命名为小单孢菌属（Micromonospora viridifaciens sp。）的新型小单孢菌属物种的潜在好氧发酵产生。 nov。 Routien，ATCC 31146。
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公开(公告)号：US4032631A
公开(公告)日：1977-06-28
申请号：US642296
申请日：1975-12-19
申请人： Walter D. Celmer , Walter P. Cullen , Charles E. Moppett , John R. Oscarson , John B. Routien , Riichiro Shibakawa , Junsuke Tone
发明人： Walter D. Celmer , Walter P. Cullen , Charles E. Moppett , John R. Oscarson , John B. Routien , Riichiro Shibakawa , Junsuke Tone
CPC分类号： C07G11/00 , A61K35/74 , Y10S435/863 , Y10S435/886
摘要： A new species of Micromonospora, designated Micromonospora saitamica sp. nov. Routien, when subjected to submerged aerobic fermentation, produces at least four antibiotics. One of these is previously reported rubradirin produced by Streptomyces achromogenes var. rubradiris NRRL 3061.
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公开(公告)号：US4048304A
公开(公告)日：1977-09-13
申请号：US662700
申请日：1976-03-01
摘要： A new polycyclic ether antibiotic with anticoccidial, insecticidal and antimicrobial activity, its production by fermentation and methods for its recovery and purification are described.
摘要翻译： 描述了具有抗球虫，杀虫和抗微生物活性的新型多环醚抗生素，其通过发酵生产及其回收和纯化方法。
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公开(公告)号：US4022885A
公开(公告)日：1977-05-10
申请号：US548421
申请日：1975-02-10
CPC分类号： A61K31/00 , C07G11/00 , Y10S435/886
摘要： A new polycyclic ether antibiotic with anticoccidial, insecticidal and antimicrobial activity, its production by fermentation and methods for its recovery and purification are described.
摘要翻译： 描述了具有抗球虫，杀虫和抗微生物活性的新型多环醚抗生素，其通过发酵生产及其回收和纯化方法。
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公开(公告)号：US4129578A
公开(公告)日：1978-12-12
申请号：US728907
申请日：1976-10-01
申请人： Walter D. Celmer , Walter P. Cullen , Mark T. Jefferson , Charles E. Moppett , John B. Routien , Frank C. Sciavolino
发明人： Walter D. Celmer , Walter P. Cullen , Mark T. Jefferson , Charles E. Moppett , John B. Routien , Frank C. Sciavolino
IPC分类号： A23K20/195 , C07H17/04 , C07H19/01 , C12P1/06 , C12P17/16 , C07D309/22 , A61K31/35
CPC分类号： C07H19/01 , Y10S435/898
摘要： A new polycyclic ether antibiotic with anticoccidial, antimicrobial and growth promotant properties, its production by fermentation and methods for its recovery and purification are described.
摘要翻译： 描述了具有抗球虫，抗微生物和生长促进剂性质的新型多环醚抗生素，其通过发酵生产及其回收和纯化方法。
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公开(公告)号：US4062945A
公开(公告)日：1977-12-13
申请号：US662701
申请日：1976-03-01
CPC分类号： A61K31/00 , C07G11/00 , Y10S435/886
摘要： A new polycyclic ether antibiotic with anticoccidial, insecticidal and antimicrobial activity, its production by fermentation and methods for its recovery and purification are described.
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公开(公告)号：US4032632A
公开(公告)日：1977-06-28
申请号：US708181
申请日：1976-07-23
申请人： Walter D. Celmer , Walter P. Cullen , Charles E. Moppett , John B. Routien , Mark T. Jefferson , Riichiro Shibakawa , Junsuke Tone
发明人： Walter D. Celmer , Walter P. Cullen , Charles E. Moppett , John B. Routien , Mark T. Jefferson , Riichiro Shibakawa , Junsuke Tone
CPC分类号： A61K35/74 , C07G11/00 , Y10S435/822
摘要： Two new species of Streptosporangium, designated Streptosporangium koreanum Routien sp. nov. and Streptosporangium cinnabarinum Routien sp. nov., when subjected to submerged aerobic fermentation, produce the same two new antibiotics. Methods for the recovery and purification of these antibiotics, co-produced with minor antibiotics, are described and some of their antimicrobial properties are outlined.
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公开(公告)号：US4148880A
公开(公告)日：1979-04-10
申请号：US751032
申请日：1976-12-16
申请人： Walter D. Celmer , Walter P. Cullen , Charles E. Moppett , John B. Routien , Riichiro Shibakawa , Junsuke Tone
发明人： Walter D. Celmer , Walter P. Cullen , Charles E. Moppett , John B. Routien , Riichiro Shibakawa , Junsuke Tone
CPC分类号： A61K35/742 , C07G11/00
摘要： A species of Actinoplanes, designated Actinoplanes auranticolor ATCC 31011, when subjected to submerged aerobic fermentation under controlled conditions, produces a mixture of antibiotics which includes a number of macrocyclic lactones and depsipeptides. The individual compounds exhibit significant antibiotic activity. The crude antibiotic mixture or combinations of a pure macrocyclic lactone and a pure depsipeptide demonstrate marked synergistic antibiotic activity. These antibiotics act as growth promotants in chicks and swine and are effective in the treatment of swine dysentery.This mixture of antibiotics is also produced by a species of Actinoplanes designated Actinoplanes azureus ATCC 31157. In addition, this culture produces a mixture of heptaene antibiotics with antifungal properties.
摘要翻译： 当在受控条件下进行淹没好氧发酵时，称为Actinoplanes auranticolor ATCC 31011的一种Actinoplanes产生包含许多大环内酯和缩酚酸肽的抗生素混合物。 各种化合物显示出显着的抗生素活性。 粗制抗生素混合物或纯大环内酯和纯赖肽的组合显示明显的协同抗生素活性。 这些抗生素作为小鸡和猪的生长促进剂，对猪痢疾的治疗是有效的。
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公开(公告)号：US4081532A
公开(公告)日：1978-03-28
申请号：US724869
申请日：1976-09-20
申请人： Walter D. Celmer , Walter P. Cullen , Charles E. Moppett , John B. Routien , Mark T. Jefferson , Riichiro Shibakawa , Junsuke Tone
发明人： Walter D. Celmer , Walter P. Cullen , Charles E. Moppett , John B. Routien , Mark T. Jefferson , Riichiro Shibakawa , Junsuke Tone
IPC分类号： C12P7/00 , A23K20/195 , A61K35/74 , A61P31/04 , C07D493/20 , C07G11/00 , C12P1/02 , C12P17/18 , C12R1/645 , A61K35/00
CPC分类号： A23K20/195 , Y10S435/911
摘要： A new polycyclic ether antibiotic produced by three strains of a new species of Dactylosporangium under submerged fermentation conditions is useful in controlling coccidiosis in poultry and in improving feed utilization efficiency in ruminants.
摘要翻译： 在浸没发酵条件下，由三种新孢子菌产生的新型多环醚抗生素可用于防治家禽中的球虫病，提高反刍动物饲料利用效率。
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公开(公告)号：US4001397A
公开(公告)日：1977-01-04
申请号：US603366
申请日：1975-08-11
申请人： Walter D. Celmer , Charles E. Moppett , Walter P. Cullen , John B. Routien , Mark T. Jefferson , Riichiro Shibakawa , Junsuke Tone
发明人： Walter D. Celmer , Charles E. Moppett , Walter P. Cullen , John B. Routien , Mark T. Jefferson , Riichiro Shibakawa , Junsuke Tone
CPC分类号： C07G11/00 , A61K35/74 , Y10S435/827
摘要： Disclosed is a new antibiotic, Compound 41,012, which is produced by the submerged aerobic fermentation of a new species of Actinoplanes designated Actinoplanes nipponensis sp. nov. Routien, ATCC 31145. Methods for the recovery and purification of Compound 41,012 are also described as are some of its antimicrobial properties.
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