公开(公告)号：US20060069023A1

公开(公告)日：2006-03-30

申请号：US11231101

申请日：2005-09-19

申请人： Warren Alexander ,  Donald Metcalf ,  Christopher Greenhalgh

发明人： Warren Alexander ,  Donald Metcalf ,  Christopher Greenhalgh

IPC分类号： A61K38/17

CPC分类号： C12N15/8509 ,  A01K67/0276 ,  A01K2217/05 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/02 ,  A01K2267/03 ,  A61K38/1709 ,  A61K48/00 ,  C12N2800/30

摘要： The present invention relates generally to a method for the treatment and/or prophylaxis of conditions arising from or otherwise associated with aberrations in hormone signalling. The present invention further provides an animal model useful for screening for agents capable of agonizing or antagonizing hormone signalling. More particularly, the present invention contemplates a method for the treatment and/or prophylaxis of conditions arising from or otherwise associated with aberrations in growth hormone signalling. The present invention further comprises a genetically modified animal. More particularly, the animals are genetically modified such that they have altered growth hormone signalling. The genetically modified animals of the present invention range from laboratory animals useful inter alia for animal models for studying hormone regulation and for the development of therapeutic protocols predicated, in part, on modulating hormone signalling to livestock animals. The latter may be manipulated for improved food production.

摘要翻译： 本发明一般涉及用于治疗和/或预防由激素信号传导中的异常引起或以其他方式与激素信号传导相关的病症的方法。 本发明还提供了可用于筛选能够激动或拮抗激素信号传导的药剂的动物模型。 更具体地说，本发明考虑了用于治疗和/或预防由生长激素信号传导中的异常引起或以其他方式与生物激素信号传导相关的病症的方法。 本发明还包括转基因动物。 更具体地，动物被遗传修饰，使得它们具有改变的生长激素信号传导。 本发明的转基因动物的范围从实验动物特别是用于研究激素调节的动物模型和用于开发部分地调节对家畜动物的激素信号传导的治疗方案的实验动物。 后者可能被操纵以改善粮食生产。