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    Animal model for studying hormone signalling and method of modulating the signalling
    1.
    发明申请
    Animal model for studying hormone signalling and method of modulating the signalling 审中-公开
    用于研究激素信号的动物模型和调节信号的方法

    公开(公告)号：US20060069023A1

    公开(公告)日：2006-03-30

    申请号：US11231101

    申请日：2005-09-19

    申请人： Warren Alexander ,  Donald Metcalf ,  Christopher Greenhalgh

    发明人： Warren Alexander ,  Donald Metcalf ,  Christopher Greenhalgh

    IPC分类号： A61K38/17

    CPC分类号： C12N15/8509 ,  A01K67/0276 ,  A01K2217/05 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/02 ,  A01K2267/03 ,  A61K38/1709 ,  A61K48/00 ,  C12N2800/30

    摘要： The present invention relates generally to a method for the treatment and/or prophylaxis of conditions arising from or otherwise associated with aberrations in hormone signalling. The present invention further provides an animal model useful for screening for agents capable of agonizing or antagonizing hormone signalling. More particularly, the present invention contemplates a method for the treatment and/or prophylaxis of conditions arising from or otherwise associated with aberrations in growth hormone signalling. The present invention further comprises a genetically modified animal. More particularly, the animals are genetically modified such that they have altered growth hormone signalling. The genetically modified animals of the present invention range from laboratory animals useful inter alia for animal models for studying hormone regulation and for the development of therapeutic protocols predicated, in part, on modulating hormone signalling to livestock animals. The latter may be manipulated for improved food production.

    摘要翻译： 本发明一般涉及用于治疗和/或预防由激素信号传导中的异常引起或以其他方式与激素信号传导相关的病症的方法。 本发明还提供了可用于筛选能够激动或拮抗激素信号传导的药剂的动物模型。 更具体地说，本发明考虑了用于治疗和/或预防由生长激素信号传导中的异常引起或以其他方式与生物激素信号传导相关的病症的方法。 本发明还包括转基因动物。 更具体地，动物被遗传修饰，使得它们具有改变的生长激素信号传导。 本发明的转基因动物的范围从实验动物特别是用于研究激素调节的动物模型和用于开发部分地调节对家畜动物的激素信号传导的治疗方案的实验动物。 后者可能被操纵以改善粮食生产。

    Methods of Identifying Compounds Which Modulate Granulocite-Colony Stimulating Factor (G-Csf) Dependent Processes by Modulation of the Levels of Suppressor of Cytokine Signaling (Socs)
    6.
    发明申请
    Methods of Identifying Compounds Which Modulate Granulocite-Colony Stimulating Factor (G-Csf) Dependent Processes by Modulation of the Levels of Suppressor of Cytokine Signaling (Socs) 审中-公开
    通过调节细胞因子信号抑制因子水平鉴定化合物的方法，调节粒细胞集落刺激因子（G-Csf）依赖过程

    公开(公告)号：US20070275916A1

    公开(公告)日：2007-11-29

    申请号：US10559711

    申请日：2004-06-04

    申请人： Ben Croker ,  Andrew Roberts ,  Don Metcalf ,  Warren Alexander ,  Doug Hilton ,  Nicos Nicola

    发明人： Ben Croker ,  Andrew Roberts ,  Don Metcalf ,  Warren Alexander ,  Doug Hilton ,  Nicos Nicola

    IPC分类号： A61K48/00 ,  A01K67/00 ,  C07H21/04 ,  C07K1/00

    CPC分类号： A01K67/0276 ,  A01K2217/075 ,  A01K2267/0381 ,  C07K14/4703 ,  C12N2800/30 ,  C12N2830/008

    摘要： The present invention relates generally to compounds which modulate cytokine-dependent processes. More particularly, the compounds of the present invention modulate responses to a colony stimulating factor and even more particularly to granulocyte-colony stimulating factor (G-CSF) by modulating the levels of molecules which inhibit G-CSF such as but not limited to a suppressor of cytokine signaling (SOCS) and in particular SOCS-3. The present invention further contemplates methods for regulating G-CSF-dependent processes by contacting cells in vitro with or administering to a subject a compound which up- or down-regulates the level of activity of G-CSF by modulating the level or activity of a SOCS molecule such as SOCS-3. The instant compounds are further useful for modulating a range of G-CSF-induced cellular responses including neutrophil recovery after chemotherapy or radiotherapy, mobilizing stem and progenitor cells, treating infection and treating inflammatory conditions.

    摘要翻译： 本发明一般涉及调节细胞因子依赖性过程的化合物。 更具体地，本发明的化合物通过调节抑制G-CSF的分子的水平来调节对集落刺激因子的反应，甚至更特别地调节粒细胞集落刺激因子（G-CSF），例如但不限于抑制因子 的细胞因子信号（SOCS），特别是SOCS-3。 本发明进一步考虑了通过使细胞在体外与受试者接触的方法来调节G-CSF依赖性过程的方法，所述化合物通过调节G-CSF的水平或活性来上调或下调G-CSF的活性水平 SOCS分子如SOCS-3。 本发明化合物还可用于调节一系列G-CSF诱导的细胞反应，包括化疗或放疗后的嗜中性粒细胞回收，动员干细胞和祖细胞，治疗感染和治疗炎性病症。