公开(公告)号：US20060235693A1

公开(公告)日：2006-10-19

申请号：US11109062

申请日：2005-04-19

申请人： Warren Ruderman ,  Feruz Ganikhanov

发明人： Warren Ruderman ,  Feruz Ganikhanov

IPC分类号： G10L21/00

CPC分类号： A61B1/2673

摘要： A system for imaging high speed moving objects, for example, using a scanning beam and beam delivery optics with fast signal processing. It can allow for vocal fold imaging at up to or exceeding approximately 1000 frames per second with grayscale resolution as high as about 100 micrometers or higher and up to about a 12.4 mm square or larger viewing area. The invention can provide imaging of vocal fold vibration that correlates completely with a synchronously-acquired acoustic voice signal. This can enable physicians, voice therapists and research scientists to understand the consequences of abnormal laryngeal dynamics, rather than being limited to simply observing the dynamics. Further, the application of laser technology will allow for accurate measurements of dimension. This can objectify examination findings and treatment outcomes measurement, helping to overcome the serious limitations of current perceptual-based judgments.

摘要翻译： 用于对高速移动物体进行成像的系统，例如使用具有快速信号处理的扫描光束和光束传递光学器件。 它可以允许高达或超过约1000帧/秒的声像折叠成像，灰度分辨率高达约100微米或更高，高达约12.4毫米正方形或更大的观看面积。 本发明可以提供与同步获取的声音信号完全相关的声带振动的成像。 这可以使医师，语音治疗师和研究科学家了解喉部动态异常的后果，而不仅限于简单地观察动态。 此外，激光技术的应用将允许精确的尺寸测量。 这可以客观化检查结果和治疗结果测量，有助于克服当前基于感知的判断的严重限制。

公开(公告)号：US07352458B2

公开(公告)日：2008-04-01

申请号：US11376396

申请日：2006-03-15

申请人： Xiaoliang Sunney Xie ,  Feruz Ganikhanov ,  Conor Evans

发明人： Xiaoliang Sunney Xie ,  Feruz Ganikhanov ,  Conor Evans

IPC分类号： G01J3/44

CPC分类号： G01J3/44 ,  G01J3/433 ,  G01N21/636 ,  G01N21/65 ,  G01N2021/1757 ,  G01N2021/653

摘要： A system is disclosed for detecting a nonlinear coherent field induced in a sample. The system includes optics, a modulation system, and a detector system. The optics are for directing a first electromagnetic field at a first frequency ω1 and a second electromagnetic field at a second frequency ω2 toward a focal volume such that a difference frequency ω1–ω2 is resonant with a vibrational frequency of a sample in the focal volume. The modulation system is for modulating the difference frequency ω1–ω2 such that the difference frequency ω1–ω2 is tuned in and out of the vibrational frequency of the sample of at a modulation frequency. The detector system is for detecting an optical field that is generated through non-linear interaction of ω1 and ω2 and the sample responsive to the modulation frequency.

摘要翻译： 公开了一种用于检测样品中引起的非线性相干场的系统。 该系统包括光学器件，调制系统和检测器系统。 所述光学器件用于将第一频率ω1> 1的第一电磁场和第二频率ω2 <2>的第二电磁场引向焦点体积，使得差频ω ＆lt; 1＆gt; -omega 2＆lt; 2＆gt;与焦点体积中的样本的振动频率共振。 调制系统用于调制差分频率ω1-ω2-ω2，使得差频ω1-ω2大于2 / SUB>被调谐出调制频率的样本的振动频率。 检测器系统用于检测通过ω1和ω2 2 N的非线性相互作用产生的光场，以及响应调制频率的样本。

公开(公告)号：US20070091305A1

公开(公告)日：2007-04-26

申请号：US11376396

申请日：2006-03-15

申请人： Xiaoliang Xie ,  Feruz Ganikhanov ,  Conor Evans

发明人： Xiaoliang Xie ,  Feruz Ganikhanov ,  Conor Evans

IPC分类号： G01J3/44 ,  G01N21/65

CPC分类号： G01J3/44 ,  G01J3/433 ,  G01N21/636 ,  G01N21/65 ,  G01N2021/1757 ,  G01N2021/653

摘要： A system is disclosed for detecting a nonlinear coherent field induced in a sample. The system includes optics, a modulation system, and a detector system. The optics are for directing a first electromagnetic field at a first frequency ω1 and a second electromagnetic field at a second frequency ω2 toward a focal volume such that a difference frequency ω1−ω2 is resonant with a vibrational frequency of a sample in the focal volume. The modulation system is for modulating the difference frequency ω1−ω2 such that the difference frequency ω1−ω2 is tuned in and out of the vibrational frequency of the sample at a modulation frequency. The detector system is for detecting an optical field that is generated through non-linear interaction of ω1 and ω2 and the sample responsive to the modulation frequency.

摘要翻译： 公开了一种用于检测样品中引起的非线性相干场的系统。 该系统包括光学器件，调制系统和检测器系统。 所述光学器件用于将第一频率ω1> 1的第一电磁场和第二频率ω2 <2>的第二电磁场引向焦点体积，使得差频ω ＆lt; 1＆gt; -omega 2＆lt; 2＆gt;与焦点体积中的样本的振动频率共振。 调制系统用于调制差分频率ω1-ω2-ω2，使得差频ω1-ω2大于2 / SUB>以调制频率被调谐进出样品的振动频率。 检测器系统用于检测通过ω1和ω2 2 N的非线性相互作用产生的光场，以及响应调制频率的样本。

公开(公告)号：US07414729B2

公开(公告)日：2008-08-19

申请号：US11403075

申请日：2006-04-12

申请人： Xiaoliang Sunney Xie ,  Francois Légaré ,  Feruz Ganikhanov ,  Conor Evans

发明人： Xiaoliang Sunney Xie ,  Francois Légaré ,  Feruz Ganikhanov ,  Conor Evans

IPC分类号： G01B9/02

CPC分类号： A61B5/6852 ,  A61B5/0066 ,  G01N21/65 ,  G01N2021/653 ,  G01N2021/656

摘要： A system is disclosed for detecting a signal field from a sample volume. The system includes a source system and an optical fiber system. The source system provides a first electromagnetic field at a first frequency and a second electromagnetic field at a second frequency that is different from the first frequency. The optical fiber system includes at least one optical fiber for guiding the first and second electromagnetic fields to the sample volume to generate coherent radiation characteristic of molecular vibrations by non-linear interaction of the first and second fields with the sample volume. The optical fiber system also receives the signal field resulting from the coherent radiation, and guides the signal field to a detector.

摘要翻译： 公开了一种用于从样本体积检测信号场的系统。 该系统包括源系统和光纤系统。 源系统以与第一频率不同的第二频率提供第一频率处的第一电磁场和第二电磁场。 光纤系统包括用于将第一和第二电磁场引导到样本体积的至少一个光纤，以通过第一和第二场与样本体积的非线性相互作用产生分子振动的相干辐射特性。 光纤系统还接收由相干辐射产生的信号场，并将信号场引导到检测器。

公开(公告)号：US20070088219A1

公开(公告)日：2007-04-19

申请号：US11403075

申请日：2006-04-12

申请人： Xiaoliang Xie ,  Francois Legare ,  Feruz Ganikhanov ,  Conor Evans

发明人： Xiaoliang Xie ,  Francois Legare ,  Feruz Ganikhanov ,  Conor Evans

IPC分类号： A61B5/00 ,  G01B9/02

CPC分类号： A61B5/6852 ,  A61B5/0066 ,  G01N21/65 ,  G01N2021/653 ,  G01N2021/656

摘要： A system is disclosed for detecting a signal field from a sample volume. The system includes a source system and an optical fiber system. The source system provides a first electromagnetic field at a first frequency and a second electromagnetic field at a second frequency that is different from the first frequency. The optical fiber system includes at least one optical fiber for guiding the first and second electromagnetic fields to the sample volume to generate coherent radiation characteristic of molecular vibrations by non-linear interaction of the first and second fields with the sample volume. The optical fiber system also receives the signal field resulting from the coherent radiation, and guides the signal field to a detector.

摘要翻译： 公开了一种用于从样本体积检测信号场的系统。 该系统包括源系统和光纤系统。 源系统以与第一频率不同的第二频率提供第一频率处的第一电磁场和第二电磁场。 光纤系统包括用于将第一和第二电磁场引导到样本体积的至少一个光纤，以通过第一和第二场与样本体积的非线性相互作用产生分子振动的相干辐射特性。 光纤系统还接收由相干辐射产生的信号场，并将信号场引导到检测器。