公开(公告)号：US20020177147A1

公开(公告)日：2002-11-28

申请号：US10044671

申请日：2002-01-10

Applicant: Washington State University Research Foundation

Inventor： Katrina L. Mealey ,  Steven A. Bentjen

IPC: C12Q001/68

CPC classification number: C12N15/8509 ,  A01K2217/05 ,  A01K2227/00 ,  A01K2267/02 ,  A01K2267/03 ,  A61K49/0008 ,  C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/156 ,  C12Q2600/158 ,  G01N33/6893

Abstract: This invention provides the identification of a truncation polymorphism of the mdr1 gene that is linked to ivermectin sensitivity in subjects, such as collies. Also provided are methods for detecting drug transport sensitivity in a subject, and animal models and in vitro cell systems using cells from animals having an mdr1 truncation.

Abstract translation: 本发明提供了与受试者（例如，乳制品）中的伊维菌素敏感性相关的mdr1基因的截短多态性的鉴定。 还提供了用于检测受试者中药物转运敏感性的方法，以及使用具有mdr1截短的动物的细胞的动物模型和体外细胞系统。

公开(公告)号：US20040265896A1

公开(公告)日：2004-12-30

申请号：US10896434

申请日：2004-07-21

Applicant: Washington State University Research Foundation

Inventor： Katrina L. Mealey ,  Steven A. Bentjen

IPC: C12Q001/68 ,  C12P019/34

CPC classification number: C12N15/8509 ,  A01K2217/05 ,  A01K2227/00 ,  A01K2267/02 ,  A01K2267/03 ,  A61K49/0008 ,  C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/156 ,  C12Q2600/158 ,  G01N33/6893

Abstract: This invention provides the identification of a truncation polymorphism of the mdr1 gene that is linked to ivermectin sensitivity in subjects, such as collies. Also provided are methods for detecting drug transport sensitivity in a subject, and animal models and in vitro cell systems using cells from animals having an mdr1 truncation.

Abstract translation: 本发明提供了与受试者（例如，乳制品）中的伊维菌素敏感性相关的mdr1基因的截短多态性的鉴定。 还提供了用于检测受试者中药物转运敏感性的方法，以及使用具有mdr1截短的动物的细胞的动物模型和体外细胞系统。