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公开(公告)号：US20210085618A1
公开(公告)日：2021-03-25
申请号：US16955336
申请日：2018-12-21
发明人： Gautam BEHL , Sangeeta KUMARI , Niall O'REILLY , Orla O'DONOVAN , Peter MCLOUGHLIN , David KENT , Laurence FITZHENRY , Elke BEHAEGHEL
IPC分类号： A61K9/51 , A61K9/00 , A61K31/573 , A61F9/00
摘要： This invention relates to a Nanostructured Lipid Carrier (NLC) particle comprising a therapeutic agent encapsulated therein for ocular delivery of the therapeutic agent, wherein the Nanostructured Lipid Carrier comprises: (i) a solid outer shell comprising a solid lipid, and (ii) a liquid core comprising a liquid lipid; and wherein the core comprises the therapeutic agent. Compositions of the NLC particles, use of the NLC particles, methods of treatment or prevention of an eye disorder and an eye drop dispenser are also provided.
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公开(公告)号：US20240307306A1
公开(公告)日：2024-09-19
申请号：US18612639
申请日：2024-03-21
发明人： Gautam BEHL , Sangeeta KUMARI , Niall O'REILLY , Orla O'DONOVAN , Peter MCLOUGHLIN , David KENT , Laurence FITZHENRY
CPC分类号： A61K9/1075 , A61K9/127 , A61K9/51 , B82Y5/00 , B82Y40/00
摘要： This invention relates to a composition for ophthalmic delivery of a therapeutic agent, the composition comprising an oil-in-water (o/w) microemulsion comprising a fatty acid, or fatty acid ester, as the oil phase; an aqueous phase; a surfactant; and a co-surfactant, and wherein the composition further comprise a suspension of therapeutic agent-loaded nanoparticles. Use of the composition for the treatment or prevention of an eye disorder, a method of treatment or prevention of an eye disorder and an eye drop dispenser are also provided.
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公开(公告)号：US20240207195A1
公开(公告)日：2024-06-27
申请号：US18458828
申请日：2023-08-30
发明人： Gautam BEHL , Sangeeta KUMARI , Niall O'REILLY , Orla O'DONOVAN , Peter MCLOUGHLIN , David KENT , Laurence FITZHENRY , Elke BEHAEGHEL
CPC分类号： A61K9/5123 , A61F9/0026 , A61K9/0048 , A61K31/573 , A61K45/06 , B82Y5/00
摘要： This invention relates to a Nanostructured Lipid Carrier (NLC) particle comprising a therapeutic agent encapsulated therein for ocular delivery of the therapeutic agent, wherein the Nanostructured Lipid Carrier comprises: (i) a solid outer shell comprising a solid lipid, and (ii) a liquid core comprising a liquid lipid; and wherein the core comprises the therapeutic agent. Compositions of the NLC particles, use of the NLC particles, methods of treatment or prevention of an eye disorder and an eye drop dispenser are also provided.
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公开(公告)号：US20210085603A1
公开(公告)日：2021-03-25
申请号：US16955319
申请日：2018-12-21
发明人： Gautam BEHL , Sangeeta KUMARI , Niall O'REILLY , Orla O'DONOVAN , Peter MCLOUGHLIN , David KENT , Laurence FITZHENRY
摘要： This invention relates to a composition for ophthalmic delivery of a therapeutic agent, the composition comprising an oil-in-water (o/w) microemulsion comprising a fatty acid, or fatty acid ester, as the oil phase; an aqueous phase; a surfactant; and a co-surfactant, and wherein the composition further comprise a suspension of therapeutic agent-loaded nanoparticles. Use of the composition for the treatment or prevention of an eye disorder, a method of treatment or prevention of an eye disorder and an eye drop dispenser are also provided.
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