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公开(公告)号:US20230285106A1
公开(公告)日:2023-09-14
申请号:US17927495
申请日:2021-05-31
发明人: Ramesh RAGHAVENDRA , Eoghan O'DONAGHUE , Brendan PHELAN , Colin REIDY , Nataraj Bangalore MAHESH , David SMYTH
CPC分类号: A61B90/05 , A61B17/24 , A61G10/005 , A61B2017/345
摘要: The present invention relates to a protective nasal mask device which hermetically seals the nasal region of a user during an ENT procedure. The device facilitates access to the user's nose and throat using a plurality of surgical tools. The primary advantage of the present invention is to provide a nasal mask device which protects medical professionals from disease transmission during an ENT procedure. Additional advantages include a nasal mask device which enables usage of a plurality of surgical tools during an ENT procedure, a device which at the same time, prevents exposure of biohazardous waste to medical professionals. The device hermetically seals the nasal region of a patient during an ENT procedure.
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公开(公告)号:US20210085618A1
公开(公告)日:2021-03-25
申请号:US16955336
申请日:2018-12-21
发明人: Gautam BEHL , Sangeeta KUMARI , Niall O'REILLY , Orla O'DONOVAN , Peter MCLOUGHLIN , David KENT , Laurence FITZHENRY , Elke BEHAEGHEL
IPC分类号: A61K9/51 , A61K9/00 , A61K31/573 , A61F9/00
摘要: This invention relates to a Nanostructured Lipid Carrier (NLC) particle comprising a therapeutic agent encapsulated therein for ocular delivery of the therapeutic agent, wherein the Nanostructured Lipid Carrier comprises: (i) a solid outer shell comprising a solid lipid, and (ii) a liquid core comprising a liquid lipid; and wherein the core comprises the therapeutic agent. Compositions of the NLC particles, use of the NLC particles, methods of treatment or prevention of an eye disorder and an eye drop dispenser are also provided.
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公开(公告)号:US20240307306A1
公开(公告)日:2024-09-19
申请号:US18612639
申请日:2024-03-21
发明人: Gautam BEHL , Sangeeta KUMARI , Niall O'REILLY , Orla O'DONOVAN , Peter MCLOUGHLIN , David KENT , Laurence FITZHENRY
CPC分类号: A61K9/1075 , A61K9/127 , A61K9/51 , B82Y5/00 , B82Y40/00
摘要: This invention relates to a composition for ophthalmic delivery of a therapeutic agent, the composition comprising an oil-in-water (o/w) microemulsion comprising a fatty acid, or fatty acid ester, as the oil phase; an aqueous phase; a surfactant; and a co-surfactant, and wherein the composition further comprise a suspension of therapeutic agent-loaded nanoparticles. Use of the composition for the treatment or prevention of an eye disorder, a method of treatment or prevention of an eye disorder and an eye drop dispenser are also provided.
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公开(公告)号:US11779543B2
公开(公告)日:2023-10-10
申请号:US16955336
申请日:2018-12-21
发明人: Gautam Behl , Sangeeta Kumari , Niall O'Reilly , Orla O'Donovan , Peter McLoughlin , David Kent , Laurence Fitzhenry , Elke Behaeghel
CPC分类号: A61K9/5123 , A61F9/0026 , A61K9/0048 , A61K31/573 , A61K45/06 , B82Y5/00
摘要: This invention relates to a Nanostructured Lipid Carrier (NLC) particle comprising a therapeutic agent encapsulated therein for ocular delivery of the therapeutic agent, wherein the Nanostructured Lipid Carrier comprises: (i) a solid outer shell comprising a solid lipid, and (ii) a liquid core comprising a liquid lipid; and wherein the core comprises the therapeutic agent. Compositions of the NLC particles, use of the NLC particles, methods of treatment or prevention of an eye disorder and an eye drop dispenser are also provided.
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公开(公告)号:US20200263416A1
公开(公告)日:2020-08-20
申请号:US16634543
申请日:2018-07-25
发明人: Conor WALSH
摘要: A ratchet fixing 5 for connecting an insulation layer 4 to a precast concrete panel 2, a precast concrete panel system 1 comprising the fixing 5 and a method for forming an insulated precast concrete panel system 1 comprising fixing an insulation layer 4 to a concrete panel 2 with fixings 5 in which the fixing 5 is made up of an insulation layer penetrating portion 18 and a concrete penetrating portion 19 contiguous with the insulating layer penetrating portion 18, the insulation layer penetrating portion 18 having a disc-like tension head 20 for abutting against the outer surface of the insulation layer 4 and a pawl 22 and ratchet 25 for securing the tension head 20 to the insulation layer penetrating portion 18.
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公开(公告)号:US20170019310A1
公开(公告)日:2017-01-19
申请号:US15203662
申请日:2016-07-06
发明人: Alan Davy
IPC分类号: H04L12/24 , H04L12/851 , H04L12/26
CPC分类号: H04L41/145 , H04L41/0896 , H04L43/026 , H04L43/0858 , H04L43/0888 , H04L43/0894 , H04L47/2483
摘要: A method for modelling a relationship between effective bandwidth coefficient (EBC) and mean throughput in a network includes: calculating an EBC for each sample packet trace of a specified traffic type, where the EBC is the ratio of the estimated effective bandwidth EB to mean traffic flow rate M of the sample packet trace; storing the EBC for each sample packet trace with the associated value of M; and modelling EBC versus M for a plurality of values of M for the specified traffic type. Calculating the EBC includes: setting a maximum packet delay target parameter and a violation target parameter for a specified traffic type; collecting a sample packet trace of the specified traffic type from a selected measurement point on the network; estimating the EB of the sample packet trace using the maximum packet delay target parameter and a violation target parameter; and calculating the EBC for the sample packet trace as EBC=EB/M.
摘要翻译: 用于对网络中有效带宽系数(EBC)和平均吞吐量之间的关系进行建模的方法包括:为指定流量类型的每个样本分组跟踪计算EBC,其中EBC是估计的有效带宽EB与平均流量的比率 样品包痕迹的流量M; 将每个样本数据包跟踪的EBC存储为相关联的值M; 对于指定的流量类型的多个M值,对EBC对M建模。 计算EBC包括:为指定的流量类型设置最大包延迟目标参数和违规目标参数; 从网络上的选定测量点收集指定流量类型的样本数据包跟踪; 使用最大分组延迟目标参数和违规目标参数估计样本分组跟踪的EB; 并将样本数据包跟踪的EBC计算为EBC = EB / M。
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公开(公告)号:US20230157317A1
公开(公告)日:2023-05-25
申请号:US17910656
申请日:2021-03-12
发明人: Gillian GARDINER , Peadar LAWLOR , Maria Luz PRIETO , Alan MARSH
IPC分类号: A23K10/18 , C12N1/20 , A61K35/742
CPC分类号: A23K10/18 , A61K35/742 , C12N1/205 , C12R2001/07
摘要: An isolated Bacillus altitudinis strain as deposited with the National Collection of Industrial and Marine Bacteria under the Accession No. NCIMB 43558 on 27/01/2020.
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公开(公告)号:US20220379297A1
公开(公告)日:2022-12-01
申请号:US17594964
申请日:2020-05-29
IPC分类号: B01L3/00
摘要: Broadly speaking, embodiments of the present techniques provide a modular sample processing device which allows a user to perform any number of biological processes within a single device, in the order the user requires. The device is customisable—a user may select two or more modules and connect them in series to form the device in which the biological processing takes place. Advantageously, this may enable a user to perform multiple processes within a single device and potentially outside of a laboratory (e.g. during field work) or outside of sterile/aseptic environments. Furthermore, the device is a hand-held device, which means the device is compact and easy to transport and use for field work.
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公开(公告)号:US20200087699A1
公开(公告)日:2020-03-19
申请号:US16469959
申请日:2017-12-12
IPC分类号: C12P23/00 , C12N1/12 , A23L33/105 , A61K8/9706
摘要: A method of producing zooplankton biomass rich in a target compound, the method comprising the steps of: (a) providing one or more species of microalgae and/or cyanobacteria; (b) optionally stimulating the microalgae and/or cyanobacteria; (c) contacting the microalgae and/or cyanobacteria with one or more species of zooplankton which feed thereon; and (d) collecting a portion of the zooplankton; wherein waste from the zooplankton is fed back to the microalgae and/or cyanobacteria
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公开(公告)号:US20200084670A1
公开(公告)日:2020-03-12
申请号:US16469905
申请日:2017-12-08
发明人: Steven Davy , Alan Davy
摘要: A method of managing resources of a network comprising a profile mapping step and an orchestration step. The profile mapping step comprises assigning a profile to an end user device, and the orchestration step comprising using the profile to apply rules to network elements to manage resources of the network available to the end user device.
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