公开(公告)号：US20200150097A1

公开(公告)日：2020-05-14

申请号：US16678454

申请日：2019-11-08

Applicant: Waters Technologies Corporation

Inventor： Jason Hill ,  Abhijit Tarafder ,  Michael O. Fogwill ,  Thomas McDonald ,  Sylvain Cormier

IPC: G01N30/20 ,  B01D15/40 ,  G01N30/34 ,  G01N30/32

Abstract: The disclosure relates to a system for liquid sample introduction into a chromatography system. The system includes a syringe, a first valve in fluid communication with the syringe, a second valve in fluid communication with the sample, a vessel located between, and in fluid communication with, the first and second valves, a third valve in fluid communication with the first valve, the second valve and a chromatography column, and a pump in fluid communication with the third valve and a mobile phase. When the valves are in a first position the syringe draws the sample into the vessel. The mobile phase flows to the chromatography column. When the valves are in a second position, a portion of the mobile phase flows into the vessel, mixing with and pressurizing the sample. When the valves are in a third position, the mixed and pressurized sample flows to the chromatography column.

公开(公告)号：US11340197B2

公开(公告)日：2022-05-24

申请号：US16678762

申请日：2019-11-08

Applicant: Waters Technologies Corporation

Inventor： Jason Hill ,  Abhijit Tarafder ,  Joshua Burnett ,  Michael O. Fogwill

IPC: G01N30/20 ,  B01D15/40 ,  B01D15/14 ,  G01N35/10 ,  G01N30/02

Abstract: The disclosure relates to a system for liquid sample introduction into a chromatography system. The system includes a metering device for drawing up the liquid sample, a first multi-port valve in fluid communication with a first end of the metering device and the liquid sample, a second multi-port valve in fluid communication with a second end of the metering device and a chromatography column, and a pump in fluid communication with the second multi-port valve and a mobile phase. When the valves are in a first position the metering device draws up the liquid sample filling a portion of the metering device. When the valves are in a second position, a remaining portion of the metering device is filled with the mobile phase thereby mixing with and pressurizing the liquid sample. When the valves are in a third position, the mixed and pressurized sample flows to the chromatography column.

公开(公告)号：US11280769B2

公开(公告)日：2022-03-22

申请号：US16678454

申请日：2019-11-08

Applicant: Waters Technologies Corporation

Inventor： Jason Hill ,  Abhijit Tarafder ,  Michael O. Fogwill ,  Thomas McDonald ,  Sylvain Cormier

IPC: G01N30/20 ,  B01D15/40 ,  G01N30/34 ,  G01N30/32 ,  G01N30/02

Abstract: The disclosure relates to a system for liquid sample introduction into a chromatography system. The system includes a syringe, a first valve in fluid communication with the syringe, a second valve in fluid communication with the sample, a vessel located between, and in fluid communication with, the first and second valves, a third valve in fluid communication with the first valve, the second valve and a chromatography column, and a pump in fluid communication with the third valve and a mobile phase. When the valves are in a first position the syringe draws the sample into the vessel. The mobile phase flows to the chromatography column. When the valves are in a second position, a portion of the mobile phase flows into the vessel, mixing with and pressurizing the sample. When the valves are in a third position, the mixed and pressurized sample flows to the chromatography column.

公开(公告)号：US11143634B2

公开(公告)日：2021-10-12

申请号：US16171826

申请日：2018-10-26

Applicant: Waters Technologies Corporation

Inventor： Abhijit Tarafder ,  Jason Hill ,  Joshua Shreve

IPC: G01N30/32 ,  F04B39/06 ,  G01N30/30 ,  B01D15/16

Abstract: Methodologies, systems, and computer-readable media are provided for controlling the mass flow rate within a CO2 based chromatography system. The pressure within a CO2 pump is measured and received at a computing system, and the computing system retrieves a target temperature value corresponding to the new pressure measurement within the CO2 pump. The computing system then generates a temperature control command that controls a CO2 pump heater or cooler in order to achieve the target temperature value at the CO2 pump. Thus, a target mass flow rate of CO2 from the CO2 pump is achieved by adjusting the temperature of the CO2 pump in response to changes in pressure.

公开(公告)号：US20200150098A1

公开(公告)日：2020-05-14

申请号：US16678762

申请日：2019-11-08

Applicant: Waters Technologies Corporation

Inventor： Jason Hill ,  Abhijit Tarafder ,  Joshua Burnett ,  Michael O. Fogwill

IPC: G01N30/20 ,  B01D15/40 ,  G01N30/34 ,  G01N30/32

Abstract: The disclosure relates to a system for liquid sample introduction into a chromatography system. The system includes a metering device for drawing up the liquid sample, a first multi-port valve in fluid communication with a first end of the metering device and the liquid sample, a second multi-port valve in fluid communication with a second end of the metering device and a chromatography column, and a pump in fluid communication with the second multi-port valve and a mobile phase. When the valves are in a first position the metering device draws up the liquid sample filling a portion of the metering device. When the valves are in a second position, a remaining portion of the metering device is filled with the mobile phase thereby mixing with and pressurizing the liquid sample. When the valves are in a third position, the mixed and pressurized sample flows to the chromatography column.