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1.发明申请公开(公告)号：US20180252685A1
公开(公告)日：2018-09-06
申请号：US15909275
申请日：2018-03-01
Applicant: Waters Technologies Corporation
Inventor： Michael O. Fogwill , Joshua A. Shreve , Michael Eggertson , Thomas S. McDonald , Joseph D. Michienzi , Abhijit Tarafder
CPC classification number: G01N30/32 , B01D15/163 , B01D15/40 , G01N30/34 , G01N30/7233 , G01N2030/326
Abstract: The present disclosure relates to methodologies, systems and apparatus for controlling pressure in a CO2-based chromatography system. A first pressure control element is located downstream of a CO2-based chromatography system and is disposed to control pressure within the column. A split restrictor is located downstream of the primary pressure control element and is disposed to divert a portion of the mobile phase flow to a detector. A second pressure control element is located downstream of the split restrictor and is disposed to control pressure at the restrictor. While the first pressure control element executes a pressure-controlled gradient separation, the second pressure control element maintains a constant pressure at the restrictor. During a composition-programmed gradient separation, the second control element maintains a constant pressure at the split restrictor while the first pressure control element maintains a constant average density across the column.
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公开(公告)号：US20220226750A1
公开(公告)日：2022-07-21
申请号：US17716367
申请日：2022-04-08
Applicant: Waters Technologies Corporation
Inventor： Zongren Shang , Stanislaw Koziol , Joseph D. Michienzi , Michael Eggertson , Keith Fadgen
Abstract: A variable fluidic restrictor of a liquid chromatography system including a stator body, the stator body include a plurality of fluidic channels located within the stator body, wherein each fluidic channel of the plurality of fluidic channels includes a restrictor element, wherein a flow of a fluid through the variable fluidic restrictor is selectively restricted based on a position of an external element coupled to the stator body is provided. Furthermore, an associated method is also provided.
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Patent Agency Ranking
公开(公告)号：US11242871B2
公开(公告)日：2022-02-08
申请号：US16573439
申请日：2019-09-17
Applicant: Waters Technologies Corporation
Inventor： Jeffrey Musacchio , Michael Eggertson , Joseph Michienzi
Abstract: A liquid chromatography solvent pump includes at least one motor, a first piston, a second piston, and a continuously variable output drive system coupling the at least one motor to at least one of the first and second pistons. The first piston and the second piston are configured to deliver a flow of solvent in a liquid chromatography system.
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公开(公告)号：US11717770B2
公开(公告)日：2023-08-08
申请号：US17716367
申请日：2022-04-08
Applicant: Waters Technologies Corporation
Inventor： Zongren Shang , Stanislaw Koziol , Joseph D. Michienzi , Michael Eggertson , Keith Fadgen
CPC classification number: B01D15/163 , G01N30/32 , G01N2030/324 , G01N2030/328
Abstract: A variable fluidic restrictor of a liquid chromatography system including a stator body, the stator body include a plurality of fluidic channels located within the stator body, wherein each fluidic channel of the plurality of fluidic channels includes a restrictor element, wherein a flow of a fluid through the variable fluidic restrictor is selectively restricted based on a position of an external element coupled to the stator body is provided. Furthermore, an associated method is also provided.
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公开(公告)号：US11325055B2
公开(公告)日：2022-05-10
申请号：US16545845
申请日：2019-08-20
Applicant: Waters Technologies Corporation
Inventor： Zongren Shang , Stanislaw Koziol , Joseph D. Michienzi , Michael Eggertson , Keith Fadgen
Abstract: A variable fluidic restrictor of a liquid chromatography system including a stator body, the stator body include a plurality of fluidic channels located within the stator body, wherein each fluidic channel of the plurality of fluidic channels includes a restrictor element, wherein a flow of a fluid through the variable fluidic restrictor is selectively restricted based on a position of an external element coupled to the stator body is provided. Furthermore, an associated method is also provided.
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公开(公告)号：US20200088221A1
公开(公告)日：2020-03-19
申请号：US16573439
申请日：2019-09-17
Applicant: Waters Technologies Corporation
Inventor： Jeffrey Musacchio , Michael Eggertson , Joseph Michienzi
Abstract: A liquid chromatography solvent pump includes at least one motor, a first piston, a second piston, and a continuously variable output drive system coupling the at least one motor to at least one of the first and second pistons. The first piston and the second piston are configured to deliver a flow of solvent in a liquid chromatography system.
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公开(公告)号：US10359403B2
公开(公告)日：2019-07-23
申请号：US15909275
申请日：2018-03-01
Applicant: Waters Technologies Corporation
Inventor： Michael O. Fogwill , Joshua A. Shreve , Michael Eggertson , Thomas S. McDonald , Joseph D. Michienzi , Abhijit Tarafder
Abstract: The present disclosure relates to methodologies, systems and apparatus for controlling pressure in a CO2-based chromatography system. A first pressure control element is located downstream of a CO2-based chromatography system and is disposed to control pressure within the column. A split restrictor is located downstream of the primary pressure control element and is disposed to divert a portion of the mobile phase flow to a detector. A second pressure control element is located downstream of the split restrictor and is disposed to control pressure at the restrictor. While the first pressure control element executes a pressure-controlled gradient separation, the second pressure control element maintains a constant pressure at the restrictor. During a composition-programmed gradient separation, the second control element maintains a constant pressure at the split restrictor while the first pressure control element maintains a constant average density across the column.
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