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1.发明申请公开(公告)号：US20180284077A1
公开(公告)日：2018-10-04
申请号：US15778546
申请日：2016-11-22
发明人： Qiang Xu
CPC分类号： G01N30/22 , B01D15/305 , C07D303/14 , G01N30/30 , G01N30/34 , G01N30/7233 , G01N30/74 , G01N30/88 , G01N2030/027 , G01N2030/324 , G01N2030/8872
摘要： An improved analytical method for analysis of dianhydrogalactitol preparations provides a method for determining the purity of dianhydrogalactitol and detecting impurities in preparations of dianhydrogalactitol, as well as identifying any such impurities. The method employs high performance liquid chromatography (HPLC), in particular, HPLC employing a reverse phase amide column with ELSD detection; the HPLC can be followed by tandem mass spectroscopy. The method can further comprise the step of performing preparative HPLC collection of at least one specific substance peak present in a preparation of dianhydrogalactitol.
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公开(公告)号：US10060886B2
公开(公告)日：2018-08-28
申请号：US14612532
申请日：2015-02-03
CPC分类号： G01N30/34 , F04B23/04 , F04B49/065
摘要： Described is a method of generating a flow having a composition gradient such as a mobile phase gradient for liquid chromatography. A pair of pumps is operated such that the initiations of pump strokes for one pump are controlled to occur between the initiations of pump strokes for the other pump so that the sequences of pump strokes fort the two pumps are interspersed in time. Initiations of the pump strokes of the second pump are offset in time relative to initiations of the pump strokes of the first pump such that variations in the flow rates of the first and second pumps due to initiation do not overlap in time. The volume of liquid contributed by a pump stroke is controlled according to the relative contribution of the respective pump to the composition gradient.
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公开(公告)号：US20180224006A1
公开(公告)日：2018-08-09
申请号：US15877679
申请日：2018-01-23
发明人： Graham Robert Killip
IPC分类号： F16K11/074 , G01N30/20 , G01N30/38
CPC分类号： F16K11/0743 , G01N30/20 , G01N30/34 , G01N30/38 , G01N2030/201 , G01N2030/347 , Y10T137/86823 , Y10T137/87249 , G01N2030/202
摘要： A blend valve assembly including a plurality of ports, a stator having at least one fluid flow path defined therein that extends between at least one port of the plurality of ports in communication with the primary fluid media and at least one port of the plurality of ports in communication with an intake of a testing device, and a rotor comprising at least one fluid flow path defined therein. The rotor is movable between a series of positions such that the blend valve assembly is operable to provide the intake of the testing device with only the primary fluid media and to provide the intake of the testing device with a blend of the primary fluid media and the secondary fluid media.
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4.发明申请公开(公告)号：US20180196019A1
公开(公告)日：2018-07-12
申请号：US15850146
申请日：2017-12-21
CPC分类号： G01N30/26 , G01N30/20 , G01N30/34 , G01N30/462 , G01N30/463 , G01N30/465 , G01N30/60 , B01D15/40
摘要： A method of performing a chromatographic separation includes modulating a portion of a flowstream to a trap column to retain at least one analyte from the flowstream on the trap column. A flow of a modifier is provided through the trap column to generate an elution comprising the at least one analyte. A flow of a compressible fluid-based chromatography (CFC) mobile phase or CFC solvent is merged with the elution from the trap column to generate a diluted elution. Carbon dioxide may be used as the CFC solvent or as a component of the CFC mobile phase. The diluted elution is provided to a CFC column where at least one analyte is focused at a head of the CFC column. Examples of a flowstream that may be used include an eluent from a chromatography column or a fluid flow from an extraction system.
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公开(公告)号：US10005006B2
公开(公告)日：2018-06-26
申请号：US14661793
申请日：2015-03-18
申请人： DIONEX SOFTRON GMBH
CPC分类号： B01D15/166 , G01N30/34
摘要： The invention relates to a method for setting a gradient delay volume GDV of a liquid chromatography system for a chromatography run in liquid chromatography, in particular a high-performance liquid chromatography system, in which a desired value GDVtarget of a gradient delay volume of the liquid chromatography system is ascertained or predefined and, if the value GDVtarget deviates from a specific fixed value GDVactual of a liquid chromatography system, this value GDVtarget is set in a range 0≤ΔGDV=GDVtarget−GDVactual≤Vmax of a volume of a volume adjustment device 5. Furthermore, the invention relates to an automatic sampler for carrying out such a method.
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公开(公告)号：US09766216B2
公开(公告)日：2017-09-19
申请号：US10821657
申请日：2004-04-08
IPC分类号： C12Q1/68 , G01N30/86 , G01N33/53 , G01N33/538 , G01N33/561 , B01L3/00 , G01N30/02 , G01N30/34
CPC分类号： G01N30/8644 , B01L3/5027 , B01L3/502753 , B01L2300/0816 , B01L2400/0415 , B01L2400/0487 , G01N30/02 , G01N30/34 , G01N33/5306 , G01N33/538 , G01N33/561 , B01D15/34
摘要： This invention provides methods and compositions, e.g., to reduce interference from non-specific binding sample constituents in a migration shift assay. Interference due to non-specific binding of sample constituents to an affinity substance (e.g., an affinity molecule or a conjugate of an affinity molecule and a charged carrier molecule) is prevented by, e.g., binding the constituents to charged polymers such as heparin sulfate.The present invention also provides methods to concentrate an analyte of interest with high concentration and to detect the analyte with high sensitivity, and further to optimize the reaction conditions for easily concentrating the analyte. Such objects of the present invention are attained, for example, by concentrating a complex of the analyte and a conjugate which is formed by contacting the analyte in a sample with an affinity molecule bound to a charged carrier molecule such as DNA.
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公开(公告)号：US20170130345A1
公开(公告)日：2017-05-11
申请号：US15415700
申请日：2017-01-25
CPC分类号： C25B7/00 , B01D15/168 , B01D61/44 , B01D61/445 , B01D61/46 , B01D2311/18 , B01D2311/2653 , G01N30/34
摘要： An electrodialytic buffer generator is described. The buffer generator may include a central buffer-generating channel having an inlet and outlet, a second chamber, and a third chamber. The buffer-generating channel, the second chamber, and the third chamber may each include an electrode. The buffer generator may also include a first ion exchange barrier and a second ion exchange barrier. The first ion exchange barrier can be disposed between the second chamber and the buffer-generating channel. The second ion exchange barrier can be disposed between the third chamber and the buffer-generating channel.
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公开(公告)号：US09527010B2
公开(公告)日：2016-12-27
申请号：US12566701
申请日：2009-09-25
申请人： Alan M. Williams , Adam Kaletski , Lisa Stack , Daniel Go , John Krasnansky , David A. Wareheim , Bin Lin
发明人： Alan M. Williams , Adam Kaletski , Lisa Stack , Daniel Go , John Krasnansky , David A. Wareheim , Bin Lin
IPC分类号： B01D35/14 , C02F1/00 , C12M1/00 , B01D15/18 , G01N30/28 , G01N30/46 , G01N30/24 , G01N30/34 , B01D15/36
CPC分类号： B01D15/1871 , B01D15/1864 , B01D15/362 , G01N30/24 , G01N30/28 , G01N30/34 , G01N30/465 , B01D15/363
摘要： A separation system comprises (i) at least two separation units, each separation unit comprising a fluid inlet and a fluid outlet, wherein the separation units are connected in series outlet to inlet to form a line of separation units, and (ii) sensing and adjustment means, provided in-line between each separation unit, for continuously monitoring and adjusting at least one environmental property parameter of fluid flowing from one separation unit to a subsequent separation unit in the line of separation units. Uses of the separation system and a method for purification of a liquid containing a desired species, using separation units and in-line adjustment of a fluid flow or flows, are also disclosed.
摘要翻译： 分离系统包括（i）至少两个分离单元，每个分离单元包括流体入口和流体出口，其中分离单元以串联出口连接到入口以形成一行分离单元，以及（ii）感测和 在每个分离单元之间在线设置的调节装置，用于连续地监测和调节从一个分离单元流向分离单元的后续分离单元的流体的至少一个环境属性参数。 还公开了分离系统的使用以及使用分离单元和流体流或流的在线调节来纯化含有所需物质的液体的方法。
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公开(公告)号：US09459239B2
公开(公告)日：2016-10-04
申请号：US13178814
申请日：2011-07-08
申请人： Klaus Witt , Konstantin Choikhet
发明人： Klaus Witt , Konstantin Choikhet
CPC分类号： G01N30/34 , Y10T137/2499
摘要： A fluid supply system configured for metering two or more fluids in controlled proportions, including a plurality of solvent supply lines, a pumping unit configured for taking in fluids from selected solvent supply lines and for supplying a pressurized mixture, a proportioning valve configured for modulating solvent composition by sequentially coupling selected ones of the solvent supply lines with the inlet of the pumping unit, a sensor configured for sensing process information in the fluid supply system, an analysis entity configured for analyzing the process information for determining reciprocating element related information at a beginning of fluid intake, and a control unit configured for switching the proportioning valve to sequentially couple selected ones of the solvent supply lines to the inlet of the pumping unit at one or more switching points based on the given metering scheme and based on the reciprocating element related information.
摘要翻译： 一种流体供应系统，被配置为以受控比例计量两种或多种流体，包括多个溶剂供应管线，被配置用于从选定的溶剂供应管线吸入流体并用于供应加压混合物的泵送单元，配置用于调节溶剂的比例阀 通过将选定的溶剂供应管线与泵送单元的入口顺序耦合而构成的传感器，构造成用于感测流体供应系统中的过程信息的传感器，被配置为分析开始时确定往复元件相关信息的过程信息的分析实体 以及控制单元，其被配置用于切换所述比例阀，以基于给定的计量方案并且基于往复运动元件相关的顺序地将选定的溶剂供应管线连接到泵送单元的入口处的一个或多个切换点 信息。
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公开(公告)号：US09435785B2
公开(公告)日：2016-09-06
申请号：US14306820
申请日：2014-06-17
CPC分类号： G01N30/74 , B01D15/325 , G01N21/33 , G01N30/02 , G01N30/06 , G01N30/16 , G01N30/34 , G01N30/88 , G01N33/15 , G01N2030/027 , G01N2030/8818 , Y10T436/173845
摘要： Methods of analyzing purity of compositions comprising cysteamine and detecting impurities in cysteamine compositions are described.
摘要翻译： 描述了分析包含半胱胺的组合物的纯度和检测半胱胺组合物中的杂质的方法。
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