公开(公告)号：US11959894B2

公开(公告)日：2024-04-16

申请号：US16971216

申请日：2019-02-22

Applicant: SILCOTEK CORP.

Inventor： Jesse Bischof ,  Lucas D. Patterson ,  Gary Barone ,  Min Yuan ,  David A. Smith

IPC: G01N30/56 ,  B01D15/16 ,  B01D15/20 ,  B01D15/22 ,  B01D15/38 ,  G01N30/30 ,  G01N30/36 ,  B01J20/32 ,  G01N30/02 ,  G01N30/60

CPC classification number: G01N30/56 ,  B01D15/161 ,  B01D15/163 ,  B01D15/166 ,  B01D15/206 ,  B01D15/22 ,  B01D15/3828 ,  G01N30/30 ,  G01N30/36 ,  B01J20/3265 ,  G01N2030/027 ,  G01N2030/567 ,  G01N30/60

Abstract: LC techniques are disclosed. The LC technique includes providing a liquid chromatography system having a coated metallic fluid-contacting element, and transporting a fluid to contact the coated metallic fluid contacting element. Conditions for the transporting of the fluid are selected from the group consisting of the temperature of the fluid being greater than 150 degree Celsius, pressure urging the fluid being greater than 60 MPa, the fluid having a protein-containing analyte incompatible with one of titanium and polyether ether ketone, the fluid having a chelating agent incompatible with the one or both of the titanium or the polyether ether ketone.

公开(公告)号：US20230408465A1

公开(公告)日：2023-12-21

申请号：US18211179

申请日：2023-06-16

Applicant: Trajan Scientific Australia Pty Ltd

Inventor： Hans-Jürgen WIRTH ,  Boy Midas H. FIRME ,  Lewellwyn Joseph COATES ,  Shing Chung LAM ,  Andrew Arthur GOOLEY

IPC: G01N30/74 ,  G01N30/32 ,  G01N30/20 ,  B01D15/16 ,  B01D15/14

CPC classification number: G01N30/74 ,  G01N30/32 ,  G01N30/20 ,  B01D15/163 ,  B01D15/14 ,  G01N2030/027

Abstract: A reconfigurable capillary liquid chromatography system includes a solvent delivery manager including a first solvent pump assembly including a first pump housing or mount. A base module is further provided including a base module housing which is user accessible, or a base module bracket, and an injection valve for sample injection to a liquid chromatography column. The injection valve has an inlet port for receiving a sample and the injection valve is mounted in or on the base module housing or the base module bracket. The solvent delivery manager is configured to deliver solvent to the injection valve. A reconfigurable control system is also provided for controlling the reconfigurable capillary liquid chromatography system. The system is selectively user configurable to removably add any one or more additional components to the system such that the base module including the base module housing or bracket, the first pump housing or mount, and the user selected additional components fit within a predetermined system envelope, the additional components including any one or more of the following; a second solvent pump assembly having a second pump housing or mount, such that the selected second pump assembly is removably mountable on or within the base module housing or bracket for incorporation within the solvent delivery manager; a third pump assembly for a sample delivery module, the third pump assembly having a third pump housing or mount, such that the selected third pump assembly is removably mountable on or within the base module housing or bracket; a sample delivery module which is adapted for fluidic connection to the injection valve, wherein the selected sample delivery module is removably mountable on or within the base module housing or bracket; and an optical detector module having a detector housing or mount, such that the selected optical detector housing or mount is removably mountable on or within the base module housing or bracket. The control system is reconfigurable according to the user selected additional components.

公开(公告)号：US20190194258A1

公开(公告)日：2019-06-27

申请号：US16228802

申请日：2018-12-21

Applicant: ZHAOKE (GUANGZHOU) OPHTHALMIC DRUG COMPANY LIMITED

Inventor： Gang Li ,  Kailei Cao ,  Xiaoyi Li ,  Xiangrong Dai ,  Lei Yin ,  Juan Ling

IPC: C07K7/64 ,  C07K1/16 ,  B01D15/16 ,  B01D15/18 ,  B01D15/42 ,  B01J20/10

CPC classification number: C07K7/645 ,  B01D15/161 ,  B01D15/163 ,  B01D15/18 ,  B01D15/426 ,  B01J20/103 ,  B01J20/286 ,  B01J20/291 ,  B01J2220/58 ,  C07K1/16 ,  G01N30/30 ,  G01N30/88 ,  G01N2030/342 ,  G01N2030/8872

Abstract: A method of controlling the impurities in a cyclosporin A eye gel. A high performance liquid chromatography is performed, and chromatographic conditions are as follows: the detection wavelength is 210-230 nm; the column temperature is 60-68° C.; the flow rate is 0.8-1 ml/min; and the mobile phase A is: THF-water-phosphoric acid. The method of controlling impurities solves the problem of excipients interference and separation of many impurities at the same time, it also provides an effective method for the formulation of quality standard of impurities in this kind of preparation.

公开(公告)号：US20180252683A1

公开(公告)日：2018-09-06

申请号：US15909258

申请日：2018-03-01

Applicant: Waters Technologies Corporation

Inventor： Michael O. Fogwill ,  Joshua A. Shreve

IPC: G01N30/32 ,  G01N30/72

CPC classification number: G01N30/32 ,  B01D15/163 ,  B01D15/40 ,  G01N30/724 ,  G01N2030/326

Abstract: The present disclosure relates to methodologies, systems and devices for controlling pressure of a mobile phase in a CO2-based chromatography system. A pump is used to pump a mobile phase containing CO2 and is located upstream of a chromatography column. A primary pressure control element is located downstream of the chromatography column and controls the pressure of the mobile phase within the column. A secondary pressure control element is located downstream of the primary pressure control element and maintains the pressure of the mobile phase above a threshold value between an outlet of the primary pressure control element and the point of detection within a detector. The detector is located downstream of both the primary pressure control element and the secondary pressure control element.

公开(公告)号：US20180128720A1

公开(公告)日：2018-05-10

申请号：US15531706

申请日：2014-11-27

Applicant: Hunun Demeter Instruments Co. Ltd.

Inventor： Feng Wang

IPC: G01N1/34 ,  G01N30/20 ,  G01N30/60 ,  G01N30/88 ,  B01D15/16 ,  B01D15/42 ,  G01N35/10

CPC classification number: G01N1/34 ,  B01D15/163 ,  B01D15/426 ,  G01N30/20 ,  G01N30/40 ,  G01N30/463 ,  G01N30/465 ,  G01N30/6039 ,  G01N30/88 ,  G01N35/1097 ,  G01N2030/027 ,  G01N2030/402

Abstract: A liquid chromatography having an on-line cleaning function, comprising a first flow channel (L3), a second flow channel (L21), an analysis flow channel (L22) and waste liquid flow channels, further comprising a cleaning flow channel (L25), a direction switch valve (V1) and a multi-flow channel switch valve (V2), etc. The liquid chromatography changes the flow path of the liquid by changing the communication relationship between the two-position switch valves, thus realizes the on-line cleaning function for a first chromatographic column (C1), a middle chromatographic column (C2), a filter or a protector (B2) respectively, and realize the simultaneous on-line cleaning function for the first chromatographic column (C1) and the middle chromatographic column (C2).

公开(公告)号：US20180111060A1

公开(公告)日：2018-04-26

申请号：US15791622

申请日：2017-10-24

Applicant: Waters Technologies Corporation

Inventor： Emily J. Berg ,  Joshua A. Shreve ,  Edwin H. Denecke

IPC: B01D15/40 ,  B01D15/16

CPC classification number: B01D15/40 ,  B01D15/10 ,  B01D15/161 ,  B01D15/163 ,  B01D19/0005 ,  B01D19/0021 ,  B01D19/0042 ,  B01D19/0057 ,  B01D19/0063 ,  B01D2257/504 ,  G01N30/84

Abstract: Examples of gas liquid separators include a chamber, a fluid mixture inlet, a gas outlet and a liquid outlet. The fluid mixture inlet and the gas and liquid outlets are in fluid communication with the chamber. A fluid mixture received at the fluid mixture inlet diffuses inside the chamber and is separated into a liquid and a gas. The separated liquid is gravity-fed to the liquid outlet. The gas liquid separators have reduced dispersion and increased liquid recovery in comparison to conventional gas liquid separators used for chromatographic separations. The reduced dispersion yields an improvement in the shape of chromatographic peaks.

公开(公告)号：US09393504B2

公开(公告)日：2016-07-19

申请号：US14160678

申请日：2014-01-22

Applicant: Waters Technologies Corporation

Inventor： Geoff C. Gerhardt ,  Joseph A. Luongo

IPC: B01D15/16 ,  B01L3/00 ,  F04B13/02 ,  F04B23/04 ,  G01N30/32

CPC classification number: B01D15/163 ,  B01L3/50273 ,  B01L2200/143 ,  B01L2400/086 ,  F04B13/02 ,  F04B23/04 ,  F04B2205/09 ,  G01N30/32 ,  G01N2030/324

Abstract: A method and apparatus for monitoring and controlling nano-scale flow rate of fluid in the operating flow path of a HPLC system provide fluid flow without relying on complex calibration routines to compensate for solvent composition gradients typically used in HPLC. The apparatus and method are used to correct the flow output of a typical, analytical-scale (0.1-5 mL/min) HPLC pump to enable accurate and precise flow delivery at capillary (

Abstract translation: 用于监测和控制HPLC系统的操作流路中的纳米级流速的方法和装置提供流体流动，而不依赖于复杂的校准程序来补偿通常在HPLC中使用的溶剂组成梯度。 该装置和方法用于校正典型的分析型（0.1-5mL / min）HPLC泵的流量输出，以使毛细管（<0.1mL / min）和纳米级（< 1μL/ min）HPLC流速。

公开(公告)号：US09370729B2

公开(公告)日：2016-06-21

申请号：US12865789

申请日：2009-01-22

Applicant: Ole Vorm

Inventor： Ole Vorm

IPC: B01D15/16 ,  G01N30/32 ,  G01N30/36

CPC classification number: G01N30/32 ,  B01D15/163 ,  G01N30/36 ,  G01N2030/324 ,  G01N2030/326

Abstract: A method for controlling the flow of liquid in a high performance liquid chromatography apparatus. The method includes operating a pump, measuring the liquid pressure downstream of the pump, measuring the liquid flow rate downstream of the pump, and controlling the operation of the pump. In the method, it is automatically determined whether the pump is controlled to achieve a desired pressure or controlled to achieve a desired flow rate. Fuzzy logic can be applied in the method to determine the switch between the control modes.

Abstract translation: 一种控制高效液相色谱仪中液体流动的方法。 该方法包括操作泵，测量泵下游的液体压力，测量泵下游的液体流速，并控制泵的运行。 在该方法中，自动确定泵是否被控制以实现期望的压力或被控制以实现期望的流量。 模糊逻辑可以用于确定控制模式之间切换的方法。

公开(公告)号：US20150040756A1

公开(公告)日：2015-02-12

申请号：US14381981

申请日：2013-03-07

Applicant: Waters Technologies Corporation

Inventor： Joshua A. Shreve ,  John Maillet, JR. ,  Steven D. Trudeau ,  Paul Linderson

IPC: B01D53/04

CPC classification number: B01D53/0454 ,  B01D15/10 ,  B01D15/16 ,  B01D15/163 ,  B01D15/40 ,  B01D53/04 ,  G01N30/02 ,  G01N30/32 ,  G01N30/36 ,  G01N2030/3038 ,  G01N2030/328 ,  G05D16/00 ,  G05D16/024

Abstract: Exemplary embodiments of the present disclosure include systems, apparatuses, and methods that are directed to controlling pressure in a pressurized flow system, such as a C02-based chromatography system or other pressurized flow systems. Exemplary embodiments of the present disclosure comprise one or more apparatuses, systems or methods for implementing multiple pressure regulators to control pressure. In addition to providing pressure control, apparatuses, systems and methods described herein dampen damaging thermal effects caused by pressure drops of a mobile phase including C02.

Abstract translation: 本公开的示例性实施方案包括系统，装置和方法，其涉及控制加压流系统中的压力，例如基于CO 2的色谱系统或其它加压流系统。 本公开的示例性实施例包括用于实现多个压力调节器以控制压力的一个或多个装置，系统或方法。 除了提供压力控制之外，本文所述的装置，系统和方法还抑制由包括CO 2的流动相的压降引起的热效应的损害。

公开(公告)号：US20150034168A1

公开(公告)日：2015-02-05

申请号：US14381977

申请日：2013-03-07

Applicant: Waters Technologies Corporation

Inventor： Joshua A. Shreve ,  Paul Keenan

IPC: G01N30/32 ,  G05D7/06

CPC classification number: G01N30/32 ,  B01D15/163 ,  B01D15/40 ,  G01N2030/326 ,  G01N2030/328 ,  G05D7/0617 ,  G05D16/2013 ,  Y10T137/0396 ,  Y10T137/86002

Abstract: Exemplary embodiments of the present disclosure are directed to limiting a rate or pressurization in a reconfigurable pressurized flow system for which different system configurations can have different system volumes. In exemplary embodiments, the system can determine a limit for the rate of pressurization by configuring the system for a closed system rate of pressurization, measuring the closed system rate of pressurization at a set flow rate, and determining a relationship between the closed system rate of pressurization and the flow rate. The system can use the relationship to dynamically set the limit for different flow rates in the system.

Abstract translation: 本公开的示例性实施例涉及限制可重构加压流系统中的速率或加压，对于该可重构加压流系统，不同的系统配置可以具有不同的系统体积。 在示例性实施例中，系统可以通过将系统配置为闭合系统加压速率来确定加压速率的极限，在设定的流量下测量加压的封闭系统速率，以及确定闭合系统速率之间的关系 加压和流量。 系统可以使用该关系动态设置系统中不同流量的限制。