公开(公告)号：US20220373517A1

公开(公告)日：2022-11-24

申请号：US17739603

申请日：2022-05-09

Applicant: Waters Technologies Corporation

Inventor： Peter MacKinnon ,  Michael R. Jackson

IPC: G01N30/06 ,  G01N30/32 ,  G01N30/16

Abstract: Disclosed is a liquid chromatography system and mixer for use therein that includes a first split connected to an inlet, the first split branching the flow of fluid from the inlet into a first path and a second path; a second split connected to an outlet of the first path, the second split branching the first path into a third path and a fourth path; and a third split connected to an outlet of the second path, the third split branching the second path into a fifth path and a sixth path. The first path and the second path are offset by a first predetermined volume, the third path and the fourth path are offset by a second predetermined volume, and the fifth path and the sixth path are also offset by the second predetermined volume.

公开(公告)号：US20220244224A1

公开(公告)日：2022-08-04

申请号：US17589061

申请日：2022-01-31

Applicant: Waters Technologies Corporation

Inventor： Timothy M. Raymond ,  Peter MacKinnon ,  Michael R. Jackson

IPC: G01N30/30 ,  G01N30/54

Abstract: Described is a solvent manager for a liquid chromatography system. The solvent manager includes a temperature control module, a plurality of solvent reservoirs, a gradient proportioning valve and a degasser. The temperature control module maintains a substantially constant temperature of one or more of the plurality of solvent reservoirs, gradient proportioning valve and degasser. The temperature control module may include a thermal chamber having an enclosure with a thermally controlled internal environment and may also include an active thermal element such as one or more heaters. The enclosure may surround at least one of the plurality of solvent reservoirs, gradient proportioning valve and degasser. The temperature control module reduces the negative effects on solvent composition that result from temperature-dependent changes in solvent viscosities and solvent densities. Such changes affect the retention times of analytes eluted from the chromatographic column.

公开(公告)号：US20220091074A1

公开(公告)日：2022-03-24

申请号：US17481998

申请日：2021-09-22

Applicant: Waters Technologies Corporation

Inventor： Sean Eric Anderson ,  Peter MacKinnon

IPC: G01N30/34 ,  G01N30/32

Abstract: A continuous flow mixer for use in a chromatography system includes a first channel structure located between a mixer inlet and a mixer outlet. The first channel structure includes a first inlet branch, a second inlet branch, a plurality of outlet branches including at least a first outlet branch and a second outlet branch, a first plurality of branches splitting from the first inlet branch, each branch of the first plurality of branches connected to a different of the plurality of outlet branches, and a second plurality of branches splitting from the second inlet branch, each branch of the second plurality of branches connected to a different of the plurality of outlet branches. At least two branches of the first and second plurality of branches that are connected to the first outlet branch are offset in fluid residence time through the at least two branches.

公开(公告)号：US11185830B2

公开(公告)日：2021-11-30

申请号：US16111733

申请日：2018-08-24

Applicant: Waters Technologies Corporation

Inventor： Peter MacKinnon ,  Michael R. Jackson

IPC: B01F5/06 ,  B01F13/00 ,  B01D15/16

Abstract: A fluid mixer includes a flow splitter and a mixing chamber. The flow splitter includes an inlet for receiving a flow of fluid and is configured to split the flow of fluid into first and second fluid streams. The second fluid stream has a higher density than the first fluid stream. The mixing chamber includes a first inlet, a second inlet and a mixing well. The second inlet is positioned below the first inlet. The second inlet of the mixing chamber is configured to receive the first fluid stream and the first inlet of the mixing chamber is configured to receive the second fluid stream to promote mixing of the first and second streams in the mixing well.

公开(公告)号：US20190070572A1

公开(公告)日：2019-03-07

申请号：US16111733

申请日：2018-08-24

Applicant: Waters Technologies Corporation

Inventor： Peter MacKinnon ,  Michael R. Jackson

IPC: B01F5/06 ,  B01F13/00 ,  B01D15/16

Abstract: A fluid mixer includes a flow splitter and a mixing chamber. The flow splitter includes an inlet for receiving a flow of fluid and is configured to split the flow of fluid into first and second fluid streams. The second fluid stream has a higher density than the first fluid stream. The mixing chamber includes a first inlet, a second inlet and a mixing well. The second inlet is positioned below the first inlet. The second inlet of the mixing chamber is configured to receive the first fluid stream and the first inlet of the mixing chamber is configured to receive the second fluid stream to promote mixing of the first and second streams in the mixing well.

公开(公告)号：US11821882B2

公开(公告)日：2023-11-21

申请号：US17481998

申请日：2021-09-22

Applicant: Waters Technologies Corporation

Inventor： Sean Eric Anderson ,  Peter MacKinnon

IPC: G01N30/34 ,  G01N30/32

CPC classification number: G01N30/34 ,  G01N30/32 ,  G01N2030/326 ,  G01N2030/347

Abstract: A continuous flow mixer for use in a chromatography system includes a first channel structure located between a mixer inlet and a mixer outlet. The first channel structure includes a first inlet branch, a second inlet branch, a plurality of outlet branches including at least a first outlet branch and a second outlet branch, a first plurality of branches splitting from the first inlet branch, each branch of the first plurality of branches connected to a different of the plurality of outlet branches, and a second plurality of branches splitting from the second inlet branch, each branch of the second plurality of branches connected to a different of the plurality of outlet branches. At least two branches of the first and second plurality of branches that are connected to the first outlet branch are offset in fluid residence time through the at least two branches.

公开(公告)号：US20190070571A1

公开(公告)日：2019-03-07

申请号：US16111699

申请日：2018-08-24

Applicant: Waters Technologies Corporation

Inventor： Michael R. Jackson ,  Peter MacKinnon

IPC: B01F5/06 ,  B01F3/08 ,  B01D15/16

Abstract: A fluid mixer includes a flow splitter, a plurality of channels and a mixing chamber. The flow splitter includes an inlet for receiving a flow of fluid and is configured to split the flow of fluid into a plurality of fluid streams. Each channel conveys a corresponding one of the fluid streams. The channels have dissimilar volumes and a substantially identical pressure drop across the length of each channel. The mixing chamber includes a plurality of inlets. Each of the inlets of the mixing chamber is connected to a corresponding one of the channels.