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公开(公告)号：US11940424B2
公开(公告)日：2024-03-26
申请号：US17104772
申请日：2020-11-25
Applicant: Waters Technologies Corporation
Inventor： Timothy M. Raymond , Christopher Walden , Sean Anderson
CPC classification number: G01N30/32 , B01D15/163 , B01D15/166 , G01N30/20 , G01N30/34 , G01N2030/027 , G01N2030/205 , G01N2030/322 , G01N2030/328 , G01N2030/347
Abstract: Disclosed is a gradient proportioning valve for liquid chromatography that includes a plurality of inlet ports configured to receive a plurality of fluids, a manifold connected to each of the plurality of inlet ports configured to mix the plurality of fluids in a controlled manner to provide a fluid composition, the manifold including a plurality of conduits internal to the manifold, each of the plurality of conduits receiving fluid through a respective one of the plurality of inlet ports, an actuation mechanism having a piston located within a bored structure surrounding the piston, the actuation mechanism configured to open and close at least one of the plurality of conduits in a controlled manner where the piston and the bored structure have a tight tolerance configured to create a fluid tight seal, and a common outlet port configured to receive the fluid composition.
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公开(公告)号：US11821881B2
公开(公告)日：2023-11-21
申请号：US17104874
申请日：2020-11-25
Applicant: Waters Technologies Corporation
Inventor： Timothy M. Raymond , Christopher Walden , Sean Anderson
CPC classification number: G01N30/32 , B01D15/163 , B01D15/166 , B01F25/1051 , G01N30/20 , G01N30/34 , G01N2030/027 , G01N2030/205 , G01N2030/322 , G01N2030/328 , G01N2030/347
Abstract: Disclosed is a gradient proportioning valve for liquid chromatography that includes a plurality of inlet ports configured to receive a plurality of fluids, a manifold connected to each of the plurality of inlet ports configured to mix the plurality of fluids in a controlled manner to provide a fluid composition, the manifold including a plurality of fluid conduits internal to the manifold, each of the plurality of fluid conduits receiving fluid through a respective one of the plurality of inlet ports, each of the plurality of fluid conduits operatively communicable to a respective actuation mechanism configured to open and close each of the plurality of fluid conduits in a controlled manner, a common outlet port configured to receive the fluid composition, and a passive fluidic dampening system configured to dampen unwanted fluidic pressure pulses in the manifold where at least one of the plurality of fluid conduits is compliant.
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公开(公告)号：US20230028806A1
公开(公告)日：2023-01-26
申请号：US17865960
申请日：2022-07-15
Applicant: Waters Technologies Corporation
Inventor： Timothy M. Raymond , Sean Eric Anderson
Abstract: Described is a method for regulating a volume of liquid delivered by a peristaltic pump and a peristaltic pump system that can be used to perform the method. The method includes sensing an ambient temperature of the peristaltic pump. The peristaltic pump includes a pump motor. At least one of a motor speed and a motor operation duration is determined from the sensed temperature, a selected volume of liquid to be delivered and a predetermined correspondence of the motor speed to ambient temperature. The pump motor is operated at the determined motor speed or for the determined motor operation duration to deliver the selected volume of liquid from the peristaltic pump.
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公开(公告)号：US11821880B2
公开(公告)日：2023-11-21
申请号：US17104660
申请日：2020-11-25
Applicant: Waters Technologies Corporation
Inventor： Timothy M. Raymond , Christopher Walden , Sean Anderson
CPC classification number: G01N30/32 , B01D15/163 , B01D15/166 , B01F25/1051 , G01N30/20 , G01N30/34 , G01N2030/027 , G01N2030/205 , G01N2030/322 , G01N2030/328 , G01N2030/347
Abstract: Disclosed is a gradient proportioning valve for use in liquid chromatography that includes a plurality of inlet ports configured to receive a plurality of fluids, a manifold connected to each of the plurality of inlet ports configured to mix the plurality of fluids in a controlled manner to provide a fluid composition, the manifold including a plurality of conduits internal to the manifold, each of the plurality of conduits receiving fluid through a respective one of the plurality of inlet ports, each of the plurality of conduits operatively communicable to a respective actuation mechanism configured to open and close each of the plurality of conduits in a controlled manner, a common outlet port configured to receive the fluid composition, and an active fluidic dampening system configured to dampen unwanted fluidic pressure pulses in the manifold. Liquid chromatography systems and methods are further disclosed.
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公开(公告)号：US20210156829A1
公开(公告)日：2021-05-27
申请号：US17104660
申请日：2020-11-25
Applicant: Waters Technologies Corporation
Inventor： Timothy M. Raymond , Christopher Walden , Sean Anderson
IPC: G01N30/34
Abstract: Disclosed is a gradient proportioning valve for use in liquid chromatography that includes a plurality of inlet ports configured to receive a plurality of fluids, a manifold connected to each of the plurality of inlet ports configured to mix the plurality of fluids in a controlled manner to provide a fluid composition, the manifold including a plurality of conduits internal to the manifold, each of the plurality of conduits receiving fluid through a respective one of the plurality of inlet ports, each of the plurality of conduits operatively communicable to a respective actuation mechanism configured to open and close each of the plurality of conduits in a controlled manner, a common outlet port configured to receive the fluid composition, and an active fluidic dampening system configured to dampen unwanted fluidic pressure pulses in the manifold. Liquid chromatography systems and methods are further disclosed.
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Patent Agency Ranking
公开(公告)号：US20240241087A1
公开(公告)日：2024-07-18
申请号：US18615474
申请日：2024-03-25
Applicant: Waters Technologies Corporation
Inventor： Timothy M. Raymond , Christopher Walden , Sean Eric Anderson
CPC classification number: G01N30/32 , B01D15/163 , B01D15/166 , B01F25/1051 , G01N30/20 , G01N30/34 , G01N2030/027 , G01N2030/205 , G01N2030/322 , G01N2030/328 , G01N2030/347
Abstract: Disclosed is a gradient proportioning valve for liquid chromatography that includes a plurality of inlet ports configured to receive a plurality of fluids, a manifold connected to each of the plurality of inlet ports configured to mix the plurality of fluids in a controlled manner to provide a fluid composition, the manifold including a plurality of conduits internal to the manifold, each of the plurality of conduits receiving fluid through a respective one of the plurality of inlet ports, an actuation mechanism having a piston located within a bored structure surrounding the piston, the actuation mechanism configured to open and close at least one of the plurality of conduits in a controlled manner where the piston and the bored structure have a tight tolerance configured to create a fluid tight seal, and a common outlet port configured to receive the fluid composition.
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公开(公告)号：US11959471B2
公开(公告)日：2024-04-16
申请号：US17865960
申请日：2022-07-15
Applicant: Waters Technologies Corporation
Inventor： Timothy M. Raymond , Sean Eric Anderson
CPC classification number: F04B43/0081 , F04B43/12 , F04B49/065 , F04B49/20 , F04B2207/03
Abstract: Described is a method for regulating a volume of liquid delivered by a peristaltic pump and a peristaltic pump system that can be used to perform the method. The method includes sensing an ambient temperature of the peristaltic pump. The peristaltic pump includes a pump motor. At least one of a motor speed and a motor operation duration is determined from the sensed temperature, a selected volume of liquid to be delivered and a predetermined correspondence of the motor speed to ambient temperature. The pump motor is operated at the determined motor speed or for the determined motor operation duration to deliver the selected volume of liquid from the peristaltic pump.
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公开(公告)号：US20220244224A1
公开(公告)日：2022-08-04
申请号：US17589061
申请日：2022-01-31
Applicant: Waters Technologies Corporation
Inventor： Timothy M. Raymond , Peter MacKinnon , Michael R. Jackson
Abstract: Described is a solvent manager for a liquid chromatography system. The solvent manager includes a temperature control module, a plurality of solvent reservoirs, a gradient proportioning valve and a degasser. The temperature control module maintains a substantially constant temperature of one or more of the plurality of solvent reservoirs, gradient proportioning valve and degasser. The temperature control module may include a thermal chamber having an enclosure with a thermally controlled internal environment and may also include an active thermal element such as one or more heaters. The enclosure may surround at least one of the plurality of solvent reservoirs, gradient proportioning valve and degasser. The temperature control module reduces the negative effects on solvent composition that result from temperature-dependent changes in solvent viscosities and solvent densities. Such changes affect the retention times of analytes eluted from the chromatographic column.
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公开(公告)号：US20210156828A1
公开(公告)日：2021-05-27
申请号：US17104874
申请日：2020-11-25
Applicant: Waters Technologies Corporation
Inventor： Timothy M. Raymond , Christopher Walden , Sean Anderson
Abstract: Disclosed is a gradient proportioning valve for liquid chromatography that includes a plurality of inlet ports configured to receive a plurality of fluids, a manifold connected to each of the plurality of inlet ports configured to mix the plurality of fluids in a controlled manner to provide a fluid composition, the manifold including a plurality of fluid conduits internal to the manifold, each of the plurality of fluid conduits receiving fluid through a respective one of the plurality of inlet ports, each of the plurality of fluid conduits operatively communicable to a respective actuation mechanism configured to open and close each of the plurality of fluid conduits in a controlled manner, a common outlet port configured to receive the fluid composition, and a passive fluidic dampening system configured to dampen unwanted fluidic pressure pulses in the manifold where at least one of the plurality of fluid conduits is compliant.
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公开(公告)号：US20210156827A1
公开(公告)日：2021-05-27
申请号：US17104772
申请日：2020-11-25
Applicant: Waters Technologies Corporation
Inventor： Timothy M. Raymond , Christopher Walden , Sean Anderson
Abstract: Disclosed is a gradient proportioning valve for liquid chromatography that includes a plurality of inlet ports configured to receive a plurality of fluids, a manifold connected to each of the plurality of inlet ports configured to mix the plurality of fluids in a controlled manner to provide a fluid composition, the manifold including a plurality of conduits internal to the manifold, each of the plurality of conduits receiving fluid through a respective one of the plurality of inlet ports, an actuation mechanism having a piston located within a bored structure surrounding the piston, the actuation mechanism configured to open and close at least one of the plurality of conduits in a controlled manner where the piston and the bored structure have a tight tolerance configured to create a fluid tight seal, and a common outlet port configured to receive the fluid composition.
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