公开(公告)号：US20070113296A1

公开(公告)日：2007-05-17

申请号：US11645056

申请日：2006-12-26

申请人： Wei Liu ,  Bradley Ozenberger ,  Leeying Wu ,  Ching-Hsiung Lo ,  Steven Haney ,  Hemchand Sookdeo ,  Jee Hyung Lee

发明人： Wei Liu ,  Bradley Ozenberger ,  Leeying Wu ,  Ching-Hsiung Lo ,  Steven Haney ,  Hemchand Sookdeo ,  Jee Hyung Lee

IPC分类号： A01K67/027 ,  C12Q1/68 ,  G01N33/567 ,  C07H21/04 ,  C12P21/06 ,  C12N9/12

CPC分类号： C12N9/1205

摘要： The invention provides isolated protein kinase polypeptides related to novel brain-localized protein kinases homologous to known homeodomain-interacting protein kinases (HIPKs), and the isolated nucleic acid molecules that encode these polypeptides. The novel polypeptides and nucleic acid molecules of the invention are termed HIPK4. The invention also provides genetically engineered expression vectors, host cells, and transgenic animals comprising the novel nucleic acid molecules of the invention. The invention additionally provides antisense and RNAi molecules to the nucleic acid molecules of the invention. The invention further provides inhibitors, activators, and antibodies capable of binding to the protein kinase polypeptides of the invention, and their use in the prevention and treatment of neurological disorders.

摘要翻译： 本发明提供与与已知同源结构域相互作用的蛋白激酶（HIPK）同源的新型脑定位蛋白激酶相关的分离的蛋白激酶多肽以及编码这些多肽的分离的核酸分子。 本发明的新型多肽和核酸分子称为HIPK4。 本发明还提供了遗传工程改造的表达载体，宿主细胞和包含本发明的新型核酸分子的转基因动物。 本发明还向本发明的核酸分子提供反义和RNAi分子。 本发明还提供能够结合本发明的蛋白激酶多肽的抑制剂，活化剂和抗体及其在预防和治疗神经障碍中的用途。

公开(公告)号：US06900952B2

公开(公告)日：2005-05-31

申请号：US10677820

申请日：2003-10-01

申请人： Stephen Eisenbies ,  Steven Haney

发明人： Stephen Eisenbies ,  Steven Haney

IPC分类号： G02B7/182 ,  G02B7/02

CPC分类号： G02B7/1824

摘要： The present invention provides a two-piece apparatus for holding and aligning the MEMS deformable mirror. The two-piece apparatus comprises a holding plate for fixedly holding an adaptive optics element in an overall optical system and a base spatially fixed with respect to the optical system and adapted for mounting and containing the holding plate. The invention further relates to a means for configuring the holding plate through adjustments to each of a number of off-set pads touching each of three orthogonal plane surfaces on the base, wherein through the adjustments the orientation of the holding plate, and the adaptive optics element attached thereto, can be aligned with respect to the optical system with six degrees of freedom when aligning the plane surface of the optical element. The mounting system thus described also enables an operator to repeatedly remove and restore the adaptive element in the optical system without the need to realign the system once that element has been aligned.

摘要翻译： 本发明提供一种用于保持和对准MEMS可变形反射镜的两件式装置。 该两件式装置包括用于在整个光学系统中固定地保持自适应光学元件的保持板和相对于光学系统空间固定并适于安装和容纳保持板的基座。 本发明还涉及一种用于通过对接触每个基座上的三个正交平面的多个偏移焊盘进行调节来配置保持板的装置，其中通过调节固定板的取向和自适应光学器件 在对准光学元件的平面时，可以相对于光学系统对准具有六个自由度的元件。 如此描述的安装系统还使得操作者能够在光学系统中重复地移除和恢复自适应元件，而不需要在该元件对准之后重新对准系统。

公开(公告)号：US20050068641A1

公开(公告)日：2005-03-31

申请号：US10677820

申请日：2003-10-01

申请人： Stephen Eisenbies ,  Steven Haney

发明人： Stephen Eisenbies ,  Steven Haney

IPC分类号： G02B7/182 ,  G02B7/02

CPC分类号： G02B7/1824

摘要： The present invention provides a two-piece apparatus for holding and aligning the MEMS deformable mirror. The two-piece apparatus comprises a holding plate for fixedly holding an adaptive optics element in an overall optical system and a base spatially fixed with respect to the optical system and adapted for mounting and containing the holding plate. The invention further relates to a means for configuring the holding plate through adjustments to each of a number of off-set pads touching each of three orthogonal plane surfaces on the base, wherein through the adjustments the orientation of the holding plate, and the adaptive optics element attached thereto, can be aligned with respect to the optical system with six degrees of freedom when aligning the plane surface of the optical element. The mounting system thus described also enables an operator to repeatedly remove and restore the adaptive element in the optical system without the need to realign the system once that element has been aligned.

摘要翻译： 本发明提供一种用于保持和对准MEMS可变形反射镜的两件式装置。 该两件式装置包括用于在整个光学系统中固定地保持自适应光学元件的保持板和相对于光学系统空间固定并适于安装和容纳保持板的基座。 本发明还涉及一种用于通过对接触每个基座上的三个正交平面的多个偏移焊盘进行调节来配置保持板的装置，其中通过调节固定板的取向和自适应光学器件 在对准光学元件的平面时，可以相对于光学系统对准具有六个自由度的元件。 如此描述的安装系统还使得操作者能够在光学系统中重复地移除和恢复自适应元件，而不需要在该元件对准之后重新对准系统。