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1.发明申请Novel brain-localized protein kinases homologous to homeodomain-interacting protein kinases 失效新的脑定位蛋白激酶与同源结构域相互作用的蛋白激酶同源公开(公告)号：US20070113296A1
公开(公告)日：2007-05-17
申请号：US11645056
申请日：2006-12-26
申请人： Wei Liu , Bradley Ozenberger , Leeying Wu , Ching-Hsiung Lo , Steven Haney , Hemchand Sookdeo , Jee Hyung Lee
发明人： Wei Liu , Bradley Ozenberger , Leeying Wu , Ching-Hsiung Lo , Steven Haney , Hemchand Sookdeo , Jee Hyung Lee
IPC分类号： A01K67/027 , C12Q1/68 , G01N33/567 , C07H21/04 , C12P21/06 , C12N9/12
CPC分类号： C12N9/1205
摘要： The invention provides isolated protein kinase polypeptides related to novel brain-localized protein kinases homologous to known homeodomain-interacting protein kinases (HIPKs), and the isolated nucleic acid molecules that encode these polypeptides. The novel polypeptides and nucleic acid molecules of the invention are termed HIPK4. The invention also provides genetically engineered expression vectors, host cells, and transgenic animals comprising the novel nucleic acid molecules of the invention. The invention additionally provides antisense and RNAi molecules to the nucleic acid molecules of the invention. The invention further provides inhibitors, activators, and antibodies capable of binding to the protein kinase polypeptides of the invention, and their use in the prevention and treatment of neurological disorders.
摘要翻译： 本发明提供与与已知同源结构域相互作用的蛋白激酶（HIPK）同源的新型脑定位蛋白激酶相关的分离的蛋白激酶多肽以及编码这些多肽的分离的核酸分子。 本发明的新型多肽和核酸分子称为HIPK4。 本发明还提供了遗传工程改造的表达载体，宿主细胞和包含本发明的新型核酸分子的转基因动物。 本发明还向本发明的核酸分子提供反义和RNAi分子。 本发明还提供能够结合本发明的蛋白激酶多肽的抑制剂，活化剂和抗体及其在预防和治疗神经障碍中的用途。
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公开(公告)号：US20050170408A1
公开(公告)日：2005-08-04
申请号：US11050758
申请日：2005-02-07
IPC分类号： G01N33/50 , A61K45/00 , A61P43/00 , C07K14/47 , C07K14/705 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/566 , C07H21/04 , C07K16/28
CPC分类号： C07K14/4711 , C07K14/47
摘要： Novel proteins which contain a structural module conserved in the G protein coupled receptor superfamily, polynucleotides which encode these proteins, and methods for producing these proteins are provided. Diagnostic, therapeutic, and screening methods employing the polynucleotides and polypeptides of the present invention are also provided.
摘要翻译： 提供了含有在G蛋白偶联受体超家族中保守的结构模块的新型蛋白质，编码这些蛋白质的多核苷酸，以及用于制备这些蛋白质的方法。 还提供了使用本发明的多核苷酸和多肽的诊断，治疗和筛选方法。
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公开(公告)号：US20060248605A1
公开(公告)日：2006-11-02
申请号：US11485074
申请日：2006-07-12
申请人： Bradley Ozenberger , Jonathan Bard , Eileen Kajkowski , Jack Jacobsen , Stephen Walker , Heidi Sofia , David Howland
发明人： Bradley Ozenberger , Jonathan Bard , Eileen Kajkowski , Jack Jacobsen , Stephen Walker , Heidi Sofia , David Howland
CPC分类号： C07K14/47 , A01K67/0275 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A61K38/00 , C07K14/4711 , C07K2319/00
摘要： Novel proteins which bind human β-amyloid peptide, polynucleotides which encode these proteins, and methods for producing these proteins are provided. Diagnostic, therapeutic, and screening methods employing the polynucleotides and polypeptides of the present invention are also provided. Transgenic animals and knockout animals are also provided.
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公开(公告)号：US20050096460A1
公开(公告)日：2005-05-05
申请号：US10892379
申请日：2004-07-16
申请人： Bradley Ozenberger , Jonathan Bard , Eileen Kajkowski , Jack Jacobsen , Stephen Walker , Heidi Sofia , David Howland
发明人： Bradley Ozenberger , Jonathan Bard , Eileen Kajkowski , Jack Jacobsen , Stephen Walker , Heidi Sofia , David Howland
IPC分类号： A01K67/027 , A61K31/7105 , A61K31/711 , A61K38/00 , A61K39/395 , A61K48/00 , A61P25/28 , A61P43/00 , C07K14/47 , C07K14/705 , C07K16/28 , C07K19/00 , C12N15/09 , C12Q1/68 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/566 , C12N5/06
CPC分类号： C07K14/47 , A01K67/0275 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A61K38/00 , C07K14/4711 , C07K2319/00
摘要： Novel proteins which bind human β-amyloid peptide, polynucleotides which encode these proteins, and methods for producing these proteins are provided. Diagnostic, therapeutic, and screening methods employing the polynucleotides and polypeptides of the present invention are also provided. Transgenic animals and knockout animals are also provided.
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公开(公告)号：US20050214830A1
公开(公告)日：2005-09-29
申请号：US11050759
申请日：2005-02-07
IPC分类号： G01N33/50 , A61K45/00 , A61P43/00 , C07K14/47 , C07K14/705 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/566 , C07H21/04 , C07K16/28
CPC分类号： C07K14/4711 , C07K14/47
摘要： Novel proteins which contain a structural module conserved in the G protein coupled receptor superfamily, polynucleotides which encode these proteins, and methods for producing these proteins are provided. Diagnostic, therapeutic, and screening methods employing the polynucleotides and polypeptides of the present invention are also provided.
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6.发明申请Beta-amyloid peptide-binding proteins and polynucleotides encoding the same 失效β-淀粉样蛋白肽结合蛋白和编码其的多核苷酸公开(公告)号：US20050282999A9
公开(公告)日：2005-12-22
申请号：US10892379
申请日：2004-07-16
申请人： Bradley Ozenberger , Jonathan Bard , Eileen Kajkowski , Jack Jacobsen , Stephen Walker , Heidi Sofia , David Howland
发明人： Bradley Ozenberger , Jonathan Bard , Eileen Kajkowski , Jack Jacobsen , Stephen Walker , Heidi Sofia , David Howland
IPC分类号： A01K67/027 , A61K31/7105 , A61K31/711 , A61K38/00 , A61K39/395 , A61K48/00 , A61P25/28 , A61P43/00 , C07K14/47 , C07K14/705 , C07K16/28 , C07K19/00 , C12N15/09 , C12Q1/68 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/566 , C12N5/06
CPC分类号： C07K14/47 , A01K67/0275 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A61K38/00 , C07K14/4711 , C07K2319/00
摘要： Novel proteins which bind human β-amyloid peptide, polynucleotides which encode these proteins, and methods for producing these proteins are provided. Diagnostic, therapeutic, and screening methods employing the polynucleotides and polypeptides of the present invention are also provided. Transgenic animals and knockout animals are also provided.
摘要翻译： 提供了结合人β-淀粉样肽的新型蛋白质，编码这些蛋白质的多核苷酸，以及制备这些蛋白质的方法。 还提供了使用本发明的多核苷酸和多肽的诊断，治疗和筛选方法。 还提供转基因动物和敲除动物。
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