Saussurea Involucrate Extract, Pharmaceutical Composition and Use for Anti-Fatigue and Anti-Aging
    7.
    发明申请
    Saussurea Involucrate Extract, Pharmaceutical Composition and Use for Anti-Fatigue and Anti-Aging 审中-公开
    Saussurea Involucrate Extract,Pharmaceutical Composition and Use for Anti-Fatigue and Anti-Aging

    公开(公告)号:US20130177661A1

    公开(公告)日:2013-07-11

    申请号:US13344019

    申请日:2012-01-05

    IPC分类号: A61K36/28 A61P29/00

    CPC分类号: A61K36/28 A61K2236/30

    摘要: Disclosed are a Saussurea involucrate extract, pharmaceutical composition and use thereof for anti-fatigue and anti-aging. In the embodiments of the present invention, a low dose of ethyl acetate fraction of Saussurea involucrate (preferably 30 mg/kg) and Rutin (preferably 30 mg/kg) can inhibit MDA expression level and increase GPx activity. Additionally, both decrease the expression of COX-2, PARP and caspase-3, via downregulation of NF-kappaB, resulting in neuroprotection. Further, syringe feeding of Saussurea involucrate extract is also performed in aging mouse model. In the future, Saussurea involucrate extract of the present invention can be used in neuroprotection, particularly in treatment or prevention of cerebral diseases, nerve diseases, neurodegenerative diseases, chronic neurodegenerative diseases, aging, and fatigue, caused by oxidative injury.

    摘要翻译: 公开了一种Saussurea通用提取物,药物组合物及其用于抗疲劳和抗衰老的用途。 在本发明的实施方案中,低剂量的Saussurea比例(优选30mg / kg)和Rutin(优选30mg / kg)的乙酸乙酯级分可以抑制MDA表达水平并增加GPx活性。 另外,通过下调NF-κB,都能降低COX-2,PARP和caspase-3的表达,从而导致神经保护作用。 此外,老化小鼠模型也进行了Saussurea内rate提取物的注射器喂养。 将来,本发明的Saussurea泛酸提取物可用于神经保护,特别是在由氧化损伤引起的脑疾病,神经疾病,神经变性疾病,慢性神经变性疾病,衰老和疲劳的治疗或预防中。