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1.发明授权Aqueous extracts of Anoectochilus spp. kinsenoside and pharmaceutical compositions useful for hepatoprotection 有权Anoectochilus spp。的水提物 人参皂甙和用于肝保护的药物组合物公开(公告)号：US09072770B2
公开(公告)日：2015-07-07
申请号：US12966714
申请日：2010-12-13
申请人： Wen-Chuan Lin , Jin-Bin Wu , Hui-Ya Ho , Wei-Lii Lin , Chang-Chi Hsieh , Hsin-Sheng Tsay
发明人： Wen-Chuan Lin , Jin-Bin Wu , Hui-Ya Ho , Wei-Lii Lin , Chang-Chi Hsieh , Hsin-Sheng Tsay
IPC分类号： A61K31/7048 , A61K36/898
CPC分类号： A61K36/898 , A61K31/7048
摘要： A pharmaceutical composition useful for hepatoprotection is provided. The composition comprises an effective amount of kinsenoside or a pharmaceutically acceptable salt or ester thereof. An aqueous extract of Anoectochilus spp. is also provided. The extract is substantially free of ethyl acetate-philic components.
摘要翻译： 提供了可用于肝保护的药物组合物。 组合物包含有效量的人参皂苷或其药学上可接受的盐或酯。 Anoectochilus spp。的水提物 也提供。 提取物基本上不含乙酸乙酯 - 亲水组分。
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2.发明申请AQUEOUS EXTRACTS OF ANOECTOCHILUS SPP. KINSENOSIDE AND PHARMACEUTICAL COMPOSITIONS USEFUL FOR HEPATOPROTECTION 有权ANOECTOCHILUS SPP的AQUEOUS EXTRACTS 用于肝脏保护的生物素和药物组合物公开(公告)号：US20110142966A1
公开(公告)日：2011-06-16
申请号：US12966714
申请日：2010-12-13
申请人： Wen-Chuan LIN , Jin-Bin Wu , Hui-Ya Ho , Wei-Lii Lin , Chang-Chi Hsieh , Hsin-Sheng Tsay
发明人： Wen-Chuan LIN , Jin-Bin Wu , Hui-Ya Ho , Wei-Lii Lin , Chang-Chi Hsieh , Hsin-Sheng Tsay
IPC分类号： A61K36/898 , A61P1/16
CPC分类号： A61K36/898 , A61K31/7048
摘要： A pharmaceutical composition useful for hepatoprotection is provided. The composition comprises an effective amount of kinsenoside or a pharmaceutically acceptable salt or ester thereof. An aqueous extract of Anoectochilus spp. is also provided. The extract is substantially free of ethyl acetate-philic components.
摘要翻译： 提供了可用于肝保护的药物组合物。 组合物包含有效量的人参皂苷或其药学上可接受的盐或酯。 Anoectochilus spp。的水提物 也提供。 提取物基本上不含乙酸乙酯 - 亲水组分。
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3.发明申请Aqueous extracts of anoectochilus spp. kinsenoside-comprising pharmaceutical compositions useful for hepatoprotection and uses of the same 审中-公开水of提取物 用于肝保护的含有人参皂甙的药物组合物及其用途公开(公告)号：US20080241283A1
公开(公告)日：2008-10-02
申请号：US11898563
申请日：2007-09-13
申请人： Wen-Chuan Lin , Jin-Bin Wu , Hui-Ya Ho , Wei-Lii Lin , Chang-Chi Hsieh , Hsin-Sheng Tsay
发明人： Wen-Chuan Lin , Jin-Bin Wu , Hui-Ya Ho , Wei-Lii Lin , Chang-Chi Hsieh , Hsin-Sheng Tsay
IPC分类号： A61K36/898 , A61K31/7048 , A61P19/10 , A61P3/00 , A61P35/00 , A61P1/16 , A61P25/00
CPC分类号： A61K36/898 , A61K31/7048
摘要： A pharmaceutical composition useful for hepatoprotection is provided. The composition comprises an effective amount of kinsenoside or a pharmaceutically acceptable salt or ester thereof. An aqueous extract of Anoectochilus spp. is also provided. The extract is substantially free of ethyl acetate-philic components.
摘要翻译： 提供了可用于肝保护的药物组合物。 组合物包含有效量的人参皂苷或其药学上可接受的盐或酯。 Anoectochilus spp。的水提物 也提供。 提取物基本上不含乙酸乙酯 - 亲水组分。
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4.发明申请Method for inhibiting formation and/or activation of osteoclasts using flemingia macrophylla extract or lespedeza flavanone A 审中-公开使用黄芪提取物或les za za黄烷酮A抑制破骨细胞的形成和/或活化的方法公开(公告)号：US20110082197A1
公开(公告)日：2011-04-07
申请号：US12661656
申请日：2010-03-22
申请人： Jin-Bin Wu , Wen-Chuan Lin , Hui-Ya Ho
发明人： Jin-Bin Wu , Wen-Chuan Lin , Hui-Ya Ho
IPC分类号： A61K31/352 , A61P19/00 , A61P19/10
CPC分类号： A61K36/48 , A61K31/353
摘要： A method for inhibiting the formation and/or activation of osteoclasts in a mammal comprising administrating an effective amount of a compound of formula (I) or a pharmaceutically acceptable salt or ester thereof to the mammal is provided: Also provided is a method for the preparation of a Flemingia macrophylla extract.
摘要翻译： 提供了抑制哺乳动物中破骨细胞的形成和/或活化的方法，包括向哺乳动物施用有效量的式（I）化合物或其药学上可接受的盐或酯：制备方法 的Flemingia macrophylla提取物。
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5.发明授权Method for inhibiting activity and/or expression of matrix metalloproteinase, inhibiting phosphorylation of mitogen-activated protein kinase, and/or promoting expression of collagen using tormentic acid 有权用于抑制基质金属蛋白酶的活性和/或表达，抑制丝裂原活化蛋白激酶的磷酸化和/或促进胶原蛋白的表达的方法公开(公告)号：US08853271B2
公开(公告)日：2014-10-07
申请号：US12955336
申请日：2010-11-29
申请人： Jin-Bin Wu , Wen-Chuan Lin , Hui-Ya Ho , Sze-Ying Chen
发明人： Jin-Bin Wu , Wen-Chuan Lin , Hui-Ya Ho , Sze-Ying Chen
CPC分类号： A61K8/63 , A61K31/19 , A61K2800/782 , A61Q19/08
摘要： A method for inhibiting the activity of matrix metalloproteinase (MMP), inhibiting the expression of matrix metalloproteinase, inhibiting the phosphorylation of mitogen-activated protein kinase (MAPK), and/or promoting the expression of collagen in a mammal is provided. The method comprises administrating to the mammal an effective amount of an active component selected from a group consisting of a compound of formula (I), a pharmaceutically acceptable salt of the compound, a pharmaceutically acceptable ester of the compound, and combinations thereof:
摘要翻译： 提供了抑制基质金属蛋白酶（MMP）的活性，抑制基质金属蛋白酶的表达，抑制丝裂原活化蛋白激酶（MAPK）的磷酸化和/或促进胶原蛋白在哺乳动物中的表达的方法。 该方法包括向哺乳动物施用有效量的选自式（I）化合物，该化合物的药学上可接受的盐，该化合物的药学上可接受的酯及其组合的活性组分：
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公开(公告)号：US08569249B2
公开(公告)日：2013-10-29
申请号：US13161369
申请日：2011-06-15
申请人： Wen-Chuan Lin , Jin-Bin Wu , Hui-Ya Ho , Hung-Bo Hsiao
发明人： Wen-Chuan Lin , Jin-Bin Wu , Hui-Ya Ho , Hung-Bo Hsiao
CPC分类号： A61K31/7048
摘要： Provided is a method for inhibiting the activation of macrophages in a subject, comprising administrating to the subject an effective amount of an active component selected from the group consisting of a compound of formula (I), a pharmaceutically acceptable salt of the compound, and a pharmaceutically acceptable ester of the compound, and combinations thereof:
摘要翻译： 本发明提供抑制受试者中巨噬细胞活化的方法，其包括向受试者施用有效量的活性组分，所述有效成分选自式（I）化合物，该化合物的药学上可接受的盐，和 化合物的药学上可接受的酯，及其组合：
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7.发明申请METHOD FOR INHIBITING ACTIVITY AND/OR EXPRESSION OF MATRIX METALLOPROTEINASE, INHIBITING PHOSPHORYLATION OF MITOGEN-ACTIVATED PROTEIN KINASE, AND/OR PROMOTING EXPRESSION OF COLLAGEN USING TORMENTIC ACID 有权用于抑制基质金属蛋白酶的活性和/或表达的方法，抑制活化的蛋白激酶的磷酸化和/或促进使用扭酸的胶原的表达公开(公告)号：US20120059059A1
公开(公告)日：2012-03-08
申请号：US12955336
申请日：2010-11-29
申请人： Jin-Bin Wu , Wen-Chuan Lin , Hui-Ya Ho , Sze-Ying Chen
发明人： Jin-Bin Wu , Wen-Chuan Lin , Hui-Ya Ho , Sze-Ying Chen
IPC分类号： A61K31/191 , A61P17/00 , A61Q19/08 , A61K8/365
CPC分类号： A61K8/63 , A61K31/19 , A61K2800/782 , A61Q19/08
摘要： A method for inhibiting the activity of matrix metalloproteinase (MMP), inhibiting the expression of matrix metalloproteinase, inhibiting the phosphorylation of mitogen-activated protein kinase (MAPK), and/or promoting the expression of collagen in a mammal is provided. The method comprises administrating to the mammal an effective amount of an active component selected from a group consisting of a compound of formula (I), a pharmaceutically acceptable salt of the compound, a pharmaceutically acceptable ester of the compound, and combinations thereof:
摘要翻译： 提供了抑制基质金属蛋白酶（MMP）的活性，抑制基质金属蛋白酶的表达，抑制丝裂原活化蛋白激酶（MAPK）的磷酸化和/或促进胶原蛋白在哺乳动物中的表达的方法。 该方法包括向哺乳动物施用有效量的选自式（I）化合物，该化合物的药学上可接受的盐，该化合物的药学上可接受的酯及其组合的活性组分：
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8.发明申请Method for inhibiting activation of macrophages, inhibiting formation of osteoclasts, inhibiting function of osteoclasts, and/or activating osteoblasts 有权抑制巨噬细胞活化，抑制破骨细胞形成，抑制破骨细胞功能和/或激活成骨细胞的方法公开(公告)号：US20090306199A1
公开(公告)日：2009-12-10
申请号：US12454001
申请日：2009-05-11
申请人： Wen-Chuan Lin , Jin-Bin Wu , Hung-Bo Hsiao , Hui-Ya Ho
发明人： Wen-Chuan Lin , Jin-Bin Wu , Hung-Bo Hsiao , Hui-Ya Ho
IPC分类号： A61K31/351
CPC分类号： A61K31/7048
摘要： A method for inhibiting the activation of macrophages, inhibiting the formation of osteoclasts, inhibiting the function of osteoclasts, and/or activating osteoblasts in a mammal is provided. The method comprises the administration of an effective amount of kinsenoside of formula (I) or a pharmaceutically acceptable salt or ester thereof to the mammal:
摘要翻译： 提供了一种抑制巨噬细胞活化，抑制破骨细胞形成，抑制破骨细胞功能和/或激活成骨细胞的方法。 该方法包括向哺乳动物施用有效量的式（I）的人参皂甙或其药学上可接受的盐或酯：
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9.发明授权Method for inhibiting activation of macrophages, inhibiting formation of osteoclasts, inhibiting function of osteoclasts, and/or activating osteoblasts 有权抑制巨噬细胞活化，抑制破骨细胞形成，抑制破骨细胞功能和/或激活成骨细胞的方法公开(公告)号：US08084431B2
公开(公告)日：2011-12-27
申请号：US12454001
申请日：2009-05-11
申请人： Wen-Chuan Lin , Jin-Bin Wu , Hung-Bo Hsiao , Hui-Ya Ho
发明人： Wen-Chuan Lin , Jin-Bin Wu , Hung-Bo Hsiao , Hui-Ya Ho
IPC分类号： A61K31/70
CPC分类号： A61K31/7048
摘要： A method for inhibiting the activation of macrophages, inhibiting the formation of osteoclasts, inhibiting the function of osteoclasts, and/or activating osteoblasts in a mammal is provided. The method comprises the administration of an effective amount of kinsenoside of formula (I) or a pharmaceutically acceptable salt or ester thereof to the mammal:
摘要翻译： 提供了一种抑制巨噬细胞活化，抑制破骨细胞形成，抑制破骨细胞功能和/或激活成骨细胞的方法。 该方法包括向哺乳动物施用有效量的式（I）的人参皂甙或其药学上可接受的盐或酯：
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