公开(公告)号：US6111075A

公开(公告)日：2000-08-29

申请号：US53866

申请日：1998-04-01

申请人： Wen-feng Xu ,  Scott R. Presnell ,  David P. Yee ,  Donald C. Foster

发明人： Wen-feng Xu ,  Scott R. Presnell ,  David P. Yee ,  Donald C. Foster

IPC分类号： A61K38/00 ,  C07K14/705 ,  C12N15/12 ,  C07K7/06 ,  C07K7/08

CPC分类号： C07K14/705 ,  A61K38/00

摘要： The present invention relates to polynucleotide and polypeptide molecules for PAR4, a novel member of the protease-activated receptor family. The polypeptides, and polynucleotides encoding them, mediate biological responses and/or cellular signaling in response to proteases. Protease cleavage of PAR4 exposes a PAR4 extracellular amino terminal portion that serves as a ligand for the PAR4 receptor. PAR4 may be used as a target in drug screening, and further used to identify proteinaceous or non-proteinaceous PAR4 agonists and antagonists. The present invention also includes antibodies to the PAR4 polypeptides.

摘要翻译： 本发明涉及用于PAR4（蛋白酶活化受体家族的新成员）的多核苷酸和多肽分子。 多肽和编码它们的多核苷酸介导响应于蛋白酶的生物反应和/或细胞信号传导。 PAR4的蛋白酶切割暴露了作为PAR4受体配体的PAR4细胞外氨基末端部分。 PAR4可用作药物筛选中的靶标，并进一步用于鉴定蛋白质或非蛋白质PAR4激动剂和拮抗剂。 本发明还包括对PAR4多肽的抗体。

公开(公告)号：US07122342B1

公开(公告)日：2006-10-17

申请号：US09371333

申请日：1999-08-10

申请人： Wen-feng Xu ,  Scott R. Presnell ,  David P. Yee ,  Donald C. Foster

发明人： Wen-feng Xu ,  Scott R. Presnell ,  David P. Yee ,  Donald C. Foster

IPC分类号： C12N15/12

CPC分类号： C07K14/705

摘要： The present invention relates to polynucleotide and polypeptide molecules for PAR4, a novel member of the protease-activated receptor family. The polypeptides, and polynucleotides encoding them, mediate biological responses and/or cellular signaling in response to proteases. Protease cleavage of PAR4 exposes a PAR4 extracellular amino terminal portion that serves as a ligand for the PAR4 receptor. PAR4 may be used as a target in drug screening, and further used to identify proteinaceous or non-proteinaceous PAR4 agonists and antagonists. The present invention also includes antibodies to the PAR4 polypeptides.

公开(公告)号：US06436400B1

公开(公告)日：2002-08-20

申请号：US09479130

申请日：2000-01-07

申请人： Wen-feng Xu ,  Scott R. Presnell ,  David P. Yee ,  Donald C. Foster

发明人： Wen-feng Xu ,  Scott R. Presnell ,  David P. Yee ,  Donald C. Foster

IPC分类号： C07K1628

CPC分类号： C07K14/705 ,  A61K38/00

摘要： The present invention relates to polynucleotide and polypeptide molecules for PAR4, a novel member of the protease-activated receptor family. The polypeptides, and polynucleotides encoding them, mediate biological responses and/or cellular signaling in response to proteases. Protease cleavage of PAR4 exposes a PAR4 extracellular amino terminal portion that serves as a ligand for the PAR4 receptor. PAR4 may be used as a target in drug screening, and further used to identify proteinaceous or non-proteinaceous PAR4 agonists and antagonists. The present invention also includes antibodies to the PAR4 polypeptides.

摘要翻译： 本发明涉及用于PAR4（蛋白酶活化受体家族的新成员）的多核苷酸和多肽分子。 多肽和编码它们的多核苷酸介导响应于蛋白酶的生物反应和/或细胞信号传导。 PAR4的蛋白酶切割暴露了作为PAR4受体配体的PAR4细胞外氨基末端部分。 PAR4可用作药物筛选中的靶标，并进一步用于鉴定蛋白质或非蛋白质PAR4激动剂和拮抗剂。 本发明还包括对PAR4多肽的抗体。

公开(公告)号：US07084253B2

公开(公告)日：2006-08-01

申请号：US10187049

申请日：2002-06-28

申请人： Wenfeng Xu ,  Scott R. Presnell ,  David P. Yee ,  Donald C. Foster

发明人： Wenfeng Xu ,  Scott R. Presnell ,  David P. Yee ,  Donald C. Foster

IPC分类号： C07K14/705

CPC分类号： C07K14/705 ,  A61K38/00

摘要： The present invention relates to polynucleotide and polypeptide molecules for PAR4, a novel member of the protease-activated receptor family. The polypeptides, and polynucleotides encoding them, mediate biological responses and/or cellular signaling in response to proteases. Protease cleavage of PAR4 exposes a PAR4 extracellular amino terminal portion that serves as a ligand for the PAR4 receptor. PAR4 may be used as a target in drug screening, and further used to identify proteinaceous or non-proteinaceous PAR4 agonists and antagonists. The present invention also includes antibodies to the PAR4 polypeptides.

公开(公告)号：US20110110946A1

公开(公告)日：2011-05-12

申请号：US12905971

申请日：2010-10-15

申请人： JANE A. GROSS ,  Wenfeng Xu ,  Karen L. Madden ,  David P. Yee

发明人： JANE A. GROSS ,  Wenfeng Xu ,  Karen L. Madden ,  David P. Yee

IPC分类号： A61K39/395 ,  A61P29/00 ,  A61P37/06 ,  A61P37/02 ,  A61P3/10 ,  A61P25/28 ,  A61P11/06 ,  A61P11/00 ,  A61P11/08 ,  A61P13/12 ,  A61P35/00 ,  A61P19/02 ,  A61P7/06

CPC分类号： C07K14/70578 ,  A61K38/00 ,  C07K16/2875 ,  C07K16/2878 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2319/30

摘要： Soluble, secreted tumor necrosis factor receptor polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed. The polypeptides comprise one cysteine-rich repeat that is homologous to other tumor necrosis factor receptors, such as transmembrane activator and CAML-interactor (TACI). The polypeptides may be used for detecting ligands, agonists and antagonists. The polypeptides may also be used in methods that modulate B cell activation.

摘要翻译： 公开了可溶性，分泌的肿瘤坏死因子受体多肽，编码多肽的多核苷酸，以及相关的组合物和方法。 多肽包含与其它肿瘤坏死因子受体如跨膜激活因子和CAML相互作用因子（TACI）同源的富含半胱氨酸的重复序列。 多肽可用于检测配体，激动剂和拮抗剂。 多肽也可用于调节B细胞活化的方法。

公开(公告)号：US20110110943A1

公开(公告)日：2011-05-12

申请号：US12952048

申请日：2010-11-22

申请人： Jane A. Gross ,  Wenfeng Xu ,  Karen L. Madden ,  David P. Yee

发明人： Jane A. Gross ,  Wenfeng Xu ,  Karen L. Madden ,  David P. Yee

IPC分类号： A61K39/395 ,  C07K16/28 ,  C07K16/18 ,  A61P37/02 ,  A61P37/04 ,  A61P11/06 ,  A61P11/08 ,  A61P11/00 ,  A61P25/28 ,  A61P29/00 ,  A61P3/10 ,  A61P13/12 ,  A61P25/00

CPC分类号： C07K14/70578 ,  A61K38/00 ,  C07K16/2875 ,  C07K16/2878 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2319/30

摘要： Soluble, secreted tumor necrosis factor receptor polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed. The polypeptides comprise one cysteine-rich repeat that is homologous to other tumor necrosis factor receptors, such as transmembrane activator and CAML-interactor (TACI). The polypeptides may be used for detecting ligands, agonists and antagonists. The polypeptides may also be used in methods that modulate B cell activation.

公开(公告)号：US07772365B2

公开(公告)日：2010-08-10

申请号：US11458968

申请日：2006-07-20

申请人： Jane A. Gross ,  Wenfeng Xu ,  Karen L. Madden ,  David P. Yee

发明人： Jane A. Gross ,  Wenfeng Xu ,  Karen L. Madden ,  David P. Yee

IPC分类号： A61K38/17 ,  A61K39/395 ,  C07H21/04 ,  C12P21/04 ,  C07K14/74

CPC分类号： C07K14/70578 ,  A61K38/00 ,  C07K16/2875 ,  C07K16/2878 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2319/30

摘要： Soluble, secreted tumor necrosis factor receptor polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed. The polypeptides comprise one cysteine-rich repeat that is homologous to other tumor necrosis factor receptors, such as transmembrane activator and CAML-interactor (TACI). The polypeptides may be used for detecting ligands, agonists and antagonists. The polypeptides may also be used in methods that modulate B cell activation.

摘要翻译： 公开了可溶性，分泌的肿瘤坏死因子受体多肽，编码多肽的多核苷酸，以及相关的组合物和方法。 多肽包含与其它肿瘤坏死因子受体如跨膜激活因子和CAML相互作用因子（TACI）同源的富含半胱氨酸的重复序列。 多肽可用于检测配体，激动剂和拮抗剂。 多肽也可用于调节B细胞活化的方法。

公开(公告)号：US06420525B1

公开(公告)日：2002-07-16

申请号：US09137223

申请日：1998-08-19

申请人： David P. Yee ,  Theresa A. Deisher

发明人： David P. Yee ,  Theresa A. Deisher

IPC分类号： C07K1447

CPC分类号： C07K14/4702 ,  A61K38/00 ,  C07K2319/02

摘要： Novel ZGCL-1 transcription factor polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed. The polypeptides, agonists and antagonists may be used within methods for promoting the proliferation and/or differentiation of testis cells, and may also be used in the development of male-specific contraceptives and infertility treatments.

摘要翻译： 公开了新型ZGCL-1转录因子多肽，编码多肽的多核苷酸，以及相关组合物和方法。 可以在用于促进​​睾丸细胞增殖和/或分化的方法中使用多肽，激动剂和拮抗剂，并且还可用于开发男性特异性避孕药和不育症治疗。