公开(公告)号：US11549017B2

公开(公告)日：2023-01-10

申请号：US16124639

申请日：2018-09-07

申请人： PERKINELMER HEALTH SCIENCES, INC.

发明人： Nara Narayanan ,  Kevin Groves ,  Guojie Ho

IPC分类号： A61K51/00 ,  A61M36/14 ,  C09B23/16 ,  A61P35/00 ,  C07D403/14 ,  C07D409/08 ,  C07D209/90 ,  C07D403/08 ,  C07D401/08 ,  C07D333/74 ,  A61K49/00 ,  A61K51/04 ,  C07D209/92 ,  C07D333/50 ,  C09B1/00 ,  G01N33/58

摘要： This disclosure provides a family of compounds that absorb and fluoresce in the short wave infrared region (SWIR, optionally 1000 nm to 1300 nm), including hydrophilic compounds that exhibit absorption and emission spectral profiles in aqueous solutions substantially similar to those observed in organic solvents such as methanol or DMSO. The compounds can be chemically linked to biomolecules including proteins, nucleic acids, and therapeutic small molecules. The compounds are useful for imaging in a variety of medical, biological and diagnostic applications, including SWIR in vivo imaging of regions of interest within a mammal.

公开(公告)号：US11279704B2

公开(公告)日：2022-03-22

申请号：US16515272

申请日：2019-07-18

申请人： Katholieke Universiteit Leuven

发明人： Dorothée Bardiot ,  Gunter Carlens ,  Kai Dallmeier ,  Suzanne Kaptein ,  Michael McNaughton ,  Arnaud Marchand ,  Johan Neyts ,  Wim Smets ,  Mohamed Koukni

IPC分类号： C07D209/14 ,  C07D487/04 ,  C07D401/06 ,  C07D403/06 ,  C07D405/06 ,  C07D409/06 ,  C07D401/12 ,  C07D413/12 ,  C07D409/08 ,  C07D498/04 ,  C07D403/08 ,  C07D471/04 ,  C07D495/04 ,  C07D413/08 ,  C07D405/12 ,  C07D403/12 ,  C07D403/10 ,  C07D513/04 ,  C07D401/08 ,  C07D417/14 ,  C07D409/12 ,  C07D401/14 ,  C07D413/06

摘要： The present invention relates to a series of novel compounds, methods to prevent or treat viral infections in animals by using the novel compounds and to said novel compounds for use as a medicine, more preferably for use as a medicine to treat or prevent viral infections, particularly infections with RNA viruses, more particularly infections with viruses belonging to the family of the Flaviviridae, and yet more particularly infections with the Dengue virus. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the novel compounds, to the compositions or preparations for use as a medicine, more preferably for the prevention or treatment of viral infections. The invention also relates to processes for preparation of the compounds.

公开(公告)号：US10464930B2

公开(公告)日：2019-11-05

申请号：US16177112

申请日：2018-10-31

申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

发明人： Gregory R. Thatcher ,  Marton Siklos ,  Rui Xiong

IPC分类号： C07D409/12 ,  C07D333/56 ,  C07D333/64 ,  C07D409/04 ,  C07D409/08 ,  C12Q1/48 ,  G01N33/574

摘要： Disclosed is a compound of formula (I). or a pharmaceutically acceptable salt thereof. Also disclosed are pharmaceutical compositions including the compound of formula (I) and methods of using the compound of formula (I).

公开(公告)号：US20190062318A1

公开(公告)日：2019-02-28

申请号：US16177112

申请日：2018-10-31

申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

发明人： Gregory R. Thatcher ,  Marton Siklos ,  Rui Xiong

IPC分类号： C07D409/12 ,  G01N33/574 ,  C12Q1/48 ,  C07D409/04 ,  C07D333/64 ,  C07D333/56 ,  C07D409/08

CPC分类号： C07D409/12 ,  C07D333/56 ,  C07D333/64 ,  C07D409/04 ,  C07D409/08 ,  C12Q1/485 ,  G01N33/57484 ,  G01N2333/91205

摘要： Disclosed is a compound of formula (I). or a pharmaceutically acceptable salt thereof. Also disclosed are pharmaceutical compositions including the compound of formula (I) and methods of using the compound of formula (I).

公开(公告)号：US20180016501A1

公开(公告)日：2018-01-18

申请号：US15547063

申请日：2016-02-10

申请人： JNC CORPORATION ,  JNC PETROCHEMICAL CORPORATION

发明人： Tomohiro YANO

IPC分类号： C09K19/34 ,  C09K19/58 ,  C09K19/54 ,  C07D333/56 ,  C07D333/54 ,  C07D409/08 ,  C07D409/04 ,  C07D333/64 ,  C07D409/10 ,  C07D409/12

CPC分类号： C09K19/3491 ,  C07D333/54 ,  C07D333/56 ,  C07D333/64 ,  C07D409/04 ,  C07D409/08 ,  C07D409/10 ,  C07D409/12 ,  C09K19/30 ,  C09K19/32 ,  C09K19/34 ,  C09K19/42 ,  C09K19/54 ,  C09K19/542 ,  C09K19/586 ,  C09K2019/548 ,  G02F1/13

摘要： Provided is a liquid crystal compound that has high stability to heat, light and so forth, a high clearing point, low minimum temperature of a liquid crystal phase, small viscosity, suitable optical anisotropy, large negative dielectric anisotropy, a suitable elastic constant and excellent compatibility with other liquid crystal compounds, a liquid crystal composition containing the compound and a liquid crystal display device including the composition.The compound is represented by formula (1). For example, R1 is alkyl having 1 to 10 carbons, alkoxy having 1 to 9 carbons or alkenyl having 2 to 10 carbons; R2 is alkyl having 1 to 10 carbons, alkoxy having 1 to 9 carbons or alkenyl having 3 to 10 carbons; ring A1 is 1,4-cyclohexylene or 1,4-phenylene; ring A2 is 1,4-cyclohexylene or 1,4-phenylene; Z1 and Z2 are a single bond; Z3 is —O— or a single bond; and L1 is F, CF3 or CF2H.

公开(公告)号：US09765054B2

公开(公告)日：2017-09-19

申请号：US13981107

申请日：2012-01-23

申请人： Roland W. Bürli ,  Andrew J. Stott ,  Perla Breccia ,  Celia Dominguez ,  Ignacio Muñoz-Sanjuàn ,  Christopher A. Luckhurst ,  Samantha J. Hughes ,  Alan F. Haughan

发明人： Roland W. Bürli ,  Andrew J. Stott ,  Perla Breccia ,  Celia Dominguez ,  Ignacio Muñoz-Sanjuàn ,  Christopher A. Luckhurst ,  Samantha J. Hughes ,  Alan F. Haughan

IPC分类号： A61K31/415 ,  A61K31/505 ,  A61K31/519 ,  C07D231/12 ,  C07D239/26 ,  C07D319/08 ,  C07D487/04 ,  C07D401/06 ,  C07C259/08 ,  C07D205/04 ,  C07D207/10 ,  C07D209/44 ,  C07D209/46 ,  C07D209/82 ,  C07D211/58 ,  C07D211/70 ,  C07D213/56 ,  C07D213/74 ,  C07D215/18 ,  C07D233/61 ,  C07D237/08 ,  C07D263/32 ,  C07D265/36 ,  C07D267/14 ,  C07D277/30 ,  C07D295/155 ,  C07D317/46 ,  C07D319/18 ,  C07D401/04 ,  C07D409/08 ,  C07D413/04 ,  C07D417/08 ,  C07D471/04 ,  C07D491/10 ,  C07C311/14 ,  C07D233/64

CPC分类号： C07D401/06 ,  C07C259/08 ,  C07C311/14 ,  C07C2601/02 ,  C07C2601/14 ,  C07D205/04 ,  C07D207/10 ,  C07D209/44 ,  C07D209/46 ,  C07D209/82 ,  C07D211/58 ,  C07D211/70 ,  C07D213/56 ,  C07D213/74 ,  C07D215/18 ,  C07D231/12 ,  C07D233/61 ,  C07D233/64 ,  C07D237/08 ,  C07D239/26 ,  C07D263/32 ,  C07D265/36 ,  C07D267/14 ,  C07D277/30 ,  C07D295/155 ,  C07D317/46 ,  C07D319/18 ,  C07D401/04 ,  C07D409/08 ,  C07D413/04 ,  C07D417/08 ,  C07D471/04 ,  C07D487/04 ,  C07D491/10

摘要： Provided are certain histone deacetylase (HDAC) inhibitors of Formula I, compositions thereof, and methods of their use.

公开(公告)号：US09637467B2

公开(公告)日：2017-05-02

申请号：US14846016

申请日：2015-09-04

申请人： Allergan, Inc.

发明人： Yariv Donde ,  Jeremiah H. Nguyen ,  Karen M. Kedzie ,  Daniel W. Gil ,  John E. Donello ,  Wha-Bin Im

IPC分类号： C07D333/56 ,  A61K31/557 ,  A61K31/5575 ,  C07D333/62 ,  C07D409/08 ,  A61K31/559 ,  C07C59/90 ,  C07C69/732 ,  C07C57/26 ,  C07C57/48 ,  C07C69/738

CPC分类号： C07D333/56 ,  A61K31/557 ,  A61K31/5575 ,  A61K31/559 ,  C07C57/26 ,  C07C57/48 ,  C07C59/90 ,  C07C69/732 ,  C07C69/738 ,  C07D333/62 ,  C07D409/08

摘要： Disclosed herein is a method comprising administering a compound to a mammal suffering from an inflammatory bowel disease for the treatment of said disease, said compound having a structure according to Formula I wherein X, Y, B, R2, R3, R4, R5, R6 and n have the meanings found herein.

公开(公告)号：US09580386B2

公开(公告)日：2017-02-28

申请号：US14459540

申请日：2014-08-14

申请人： GRÜNENTHAL GMBH

发明人： Bert Nolte ,  Wolfgang Schröder ,  Klaus Linz ,  Werner Englberger ,  Hans Schick ,  Heinz Graubaum ,  Birgit Braun ,  Sigrid Ozegowski ,  József Bálint ,  Helmut Sonnenschein

IPC分类号： C07C211/00 ,  C07D209/20 ,  C07C211/40 ,  C07C215/14 ,  C07C215/42 ,  C07C217/74 ,  C07C223/04 ,  C07C229/16 ,  C07C233/36 ,  C07C233/40 ,  C07C233/41 ,  C07C233/62 ,  C07C233/79 ,  C07C235/54 ,  C07C237/06 ,  C07C275/24 ,  C07C311/07 ,  C07C311/18 ,  C07D209/12 ,  C07D209/14 ,  C07D211/62 ,  C07D213/12 ,  C07D213/82 ,  C07D231/14 ,  C07D251/54 ,  C07D295/135 ,  C07D309/08 ,  C07D333/20 ,  C07D403/08 ,  C07D409/08 ,  A61K31/135 ,  A61K45/06 ,  A61K31/136 ,  A61K31/165 ,  A61K31/18 ,  A61K31/404 ,  A61K31/53 ,  A61K31/5377 ,  C07C211/54 ,  C07C237/24 ,  C07C311/37 ,  C07D251/48

CPC分类号： C07D209/20 ,  A61K31/135 ,  A61K31/136 ,  A61K31/165 ,  A61K31/18 ,  A61K31/404 ,  A61K31/53 ,  A61K31/5377 ,  A61K45/06 ,  C07C211/40 ,  C07C211/54 ,  C07C215/14 ,  C07C215/42 ,  C07C217/74 ,  C07C223/04 ,  C07C229/16 ,  C07C233/36 ,  C07C233/40 ,  C07C233/41 ,  C07C233/62 ,  C07C233/79 ,  C07C235/54 ,  C07C237/06 ,  C07C237/24 ,  C07C275/24 ,  C07C311/07 ,  C07C311/18 ,  C07C311/37 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2601/16 ,  C07D209/12 ,  C07D209/14 ,  C07D211/62 ,  C07D213/12 ,  C07D213/82 ,  C07D231/14 ,  C07D251/48 ,  C07D251/54 ,  C07D295/135 ,  C07D309/08 ,  C07D333/20 ,  C07D403/08 ,  C07D409/08

摘要： The invention relates to compounds that have an affinity to the μ-opioid receptor and the ORL 1-receptor, methods for their production, medications containing these compounds and the use of these compounds for the treatment of pain and other conditions.

摘要翻译： 本发明涉及对μ-阿片受体和ORL1-受体具有亲和力的化合物，其生产方法，含有这些化合物的药物以及这些化合物用于治疗疼痛和其它病症的用途。

公开(公告)号：US09296762B2

公开(公告)日：2016-03-29

申请号：US14233682

申请日：2012-07-17

申请人： Laurent Lamarque ,  Olivier Maury ,  David Parker ,  Jurriaan Zwier ,  James W. Walton ,  Adrien Bourdolle

发明人： Laurent Lamarque ,  Olivier Maury ,  David Parker ,  Jurriaan Zwier ,  James W. Walton ,  Adrien Bourdolle

IPC分类号： C07F5/00 ,  C07D255/02 ,  C07F9/6558 ,  C07D401/14 ,  C07D409/08 ,  C07D401/08 ,  C07D409/14

CPC分类号： C07F5/003 ,  C07D255/02 ,  C07D401/14 ,  C07F9/65583

摘要： The present invention concerns complexing agents of formula (I) in which a, b, c, chrom1, chrom2, chrom3, R3, R4 and R5 are as defined in the description. The invention also concerns lanthanide complexes comprising said complexing agents, as well as a method for synthesizing said agents.

摘要翻译： 本发明涉及式（I）的络合剂，其中a，b，c，chrom1，chrom2，chrom3，R3，R4和R5如说明书中所定义。 本发明还涉及包含所述络合剂的镧系元素络合物，以及合成所述试剂的方法。

公开(公告)号：US09156810B2

公开(公告)日：2015-10-13

申请号：US14268264

申请日：2014-05-02

申请人： ALLERGAN, INC.

发明人： Yariv Donde ,  Jeremiah H. Nguyen ,  Karen M. Kedzie ,  Daniel W. Gil ,  John E. Donello ,  Wha-Bin Im

IPC分类号： C07D333/62 ,  A61K31/557 ,  A61K31/5575 ,  C07D333/56 ,  C07D409/08 ,  A61K31/559 ,  C07C59/90 ,  C07C69/732

CPC分类号： C07D333/56 ,  A61K31/557 ,  A61K31/5575 ,  A61K31/559 ,  C07C57/26 ,  C07C57/48 ,  C07C59/90 ,  C07C69/732 ,  C07C69/738 ,  C07D333/62 ,  C07D409/08

摘要： Disclosed herein is a method comprising administering a compound to a mammal suffering from an inflammatory bowel disease for the treatment of said disease, said compound having a structure according to Formula I wherein X, Y, B, R2, R3, R4, R5, R6 and n have the meanings found herein.

摘要翻译： 本文公开了一种方法，其包括向患有炎性肠病的哺乳动物施用化合物用于治疗所述疾病，所述化合物具有式I的结构，其中X，Y，B，R2，R3，R4，R5，R6 并且n具有本文找到的含义。